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Case Report
Jayabal Pandiaraja1*, Devadhason Darwin Britto2
1 Assistant Professor, Department of General Surgery, SRM Medical College,
Kancheepuram district, Tamil Nadu 603203, India
2 Assistant Professor, Department of General Surgery, SRM Medical College,
Kancheepuram district, Tamil Nadu 603203, India
Address reprint requests to
*Dr. Pandiaraja,
26/1 Kaveri Street,
Rajaji Nagar, Villivakkam, Tamil Nadu, Chennai, India
Article citation: Pandiaraja J, Darwin Britto D. An uncommon feature of papillary thyroid carcinoma: a case report. J Pharm Biomed Sci 2015;05(11):828–830. Available at www.jpbms.info
ABSTRACT
Most of the thyroid malignancies occur in either euthyroid or hypothyroid status. Thyroid malignancies with hyperthyroidism are very rare. There are numerous reasons for hyperthyroidism in thyroid cancer. The incidence of hyperthyroidism in thyroid malignancies
were <1%. But recent report showed increased incidence due to mutation of thyroid receptors. The problem with hyperthyroidism and thyroid cancer was diagnostic difficulty and management part, because for most of the cases of hyperthyroidism thyroid malignancies
are not suspected. This is a case report of papillary thyroid carcinoma presenting in hyperthyroid patient who has diagnostic difficulty and management.
KEYWORDS papillary thyroid carcinoma, hyperthyroidism, total thyroidectomy
REFERENCES
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8. Ragni F, Pinelli D, Facchini M, Ghedi M, Piccini I, Pasini M, et al. [Thyroid carcinoma in hyperthyroid syndromes]. G Chir. 1996;17(4):158–65.
9. dell’Erba L, Gerundini P, Caputo M, Bagnasco M. Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as “trapping only” nodule at 99mTcO4-scintigraphy. J Endocrinol Invest. 2003;26(11):1124–7.
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in
discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Original Article
Rahul Ravindra Bagul1*, Utkarsha Joshi2, Vikram Kakatkar3, Sanjay Deo4
1 Associate Professor, Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
2 Assistant Professor, Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri,Pune, India
3 Senior Resident, Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
4 Professor, Department of Orthopaedics,Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
Address reprint requests to
*Dr. Rahul R. Bagul, Department of Orthopaedics,Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
Article citation: Rahul B, Utkarsha J,Vikram K, Sanjay D. Comparative study of management of proximal humerus fractures in elderly by conservative method Versus operative locking compression plate. J Pharm Biomed Sci 2015;05(11):831–838.
Abstract:
Background Proximal humeral fracture in patients more than 65 years old, represent the third most common fracture. Treatment of proximal humerus fractures, especially displaced fractures, remains controversial. Conservative treatment has been preferred for most of the undisplaced or minimally displaced fractures. Over the years, availability of improved fixation devices, popularised the treatment of these fractures by open reduction and internal fixation. Operative treatment of proximal humerus fractures poses a challenge because of complications like malunion, non-union and avascular necrosis.Objective To study the role of conservative treatment and operative treatment by locking compression plate in the management of these fractures. To compare the results ofconservative management Versus locking plate osteosynthesis. To EVALUATE the results of treatment in terms of clinical and radiological union as well as functional outcome.
Materials and methods In the present case study, we report our experience in 60 cases in whom comparative study of management of proximal humerus fractures in elderly by conservative method Versus operative locking compression plate was done.Results As measured by Neer’s shoulder score, out of the 60 cases in our study, 8 (13.33%) had excellent functional outcome out of which 3 were treated conservatively and 5 were treated operatively, 29 (48.33%) had satisfactory outcome out of which 14 were treated conservatively and 15 were treated operatively, 19 (31.67%) had unsatisfactory outcome out of which 10 were treated conservatively and 9 were treated operatively, and 4 (6.67%) cases were failures out of which 3 were treated conservatively and 1 were treated operatively.
KEYWORDS proximal humerus fracture, old age, locking compression plate, conservative treatment
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in
discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Research Article
Uma Maheswari Biruda1*, Dishita Pagala2
1 Department of Paediatrics, GSL Medical College, Affiliated to DR NTR University
of Health Sciences, Vijayawada, Andhra Pradesh, India
2 Department of Paediatrics, GSL Medical College, Rajahmundry, Affiliated to DR NTR
University of Health Sciences, Vijayawada,Andhra Pradesh, India
Address reprint requests to
*Uma Maheswari Biruda, Department of Paediatrics, GSL Medical College, Affiliated
to DR NTR University of Health Sciences, Vijayawada, Andhra Pradesh, India
Article citation: Uma Maheswari B, DishitaP. Clinical, bacteriological and radiological study of severe pneumonia in children at a tertiary care centre. J Pharm Biomed Sci 2015;05(11):839–841.Available at www.jpbms.info
Background Pneumonia is the largest killer of children under 5 years, around the world. About four children die from pneumonia every minute. WHO definition of very severe pneumonia is a clinical diagnosis based on the presence of cough or difficulty in breathing plus at least one of the following: central cyanosis, refusal of feeds, convulsions, lethargy. The present study was done to know the risk factors, clinical, bacteriological and radiological features of severe pneumonia in children.
Methods This was a prospective study of severe pneumonia conducted in 150 children in the age group of 1 month to 5 years with clinical features of severe pneumonia. Detailed history and physical examination were done. Children were classified into severe and very severe pneumonia.
Results Study showed that 53% of children belonged to the age group of 1 month to 1 year. Fast breathing, cough and fever were the most common symptoms. Refusal of feed was present in 19% cases. Tachypnoea, chest retractions and crepitations were the most common signs. Diarrhoea (6.6%) and septicaemia (3.3%) were the associated illness; 83.3% had severe pneumonia, 16.7% had very severe pneumonia; 30% were malnourished and 66.6% were anemic.
Conclusion Pneumonia is one of the major causes of morbidity and mortality in children.
Among risk factors studied previous history of similar illness, inappropriate immunization, anaemia, malnutrition, poor housing conditions were found significant. Chest X-ray is valuable aids in the diagnosis of pneumonia in children. Severity of pneumonia and malnutrition associated illness were important risk factors for mortality.
KEYWORDS pneumonia, WHO criteria, under five, malnutrition
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in
discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Research article
Ibrahim Bakhit Yousif Elemam1*, Mohammed Abdalgadir Elsheikh2, Areeg Mohammed Ali Elnour3, Habiba Mohieldeen Mohammed Abd Elhaleem4, Awad Eljeed Abugooda Alobaid5
1 Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, Shendi University, Sudan
2 Department of Histopathology and Cytology, School of Medical Laboratory Sciences, Sharq Elneil College
3 Medical Laboratory Program, Al Yarmouk Colleges, Sudan
4 Faculty of Medical Laboratory Sciences, Shendi University, Sudan, Sudan
5 Medical Laboratory Program, Al Yarmouk Colleges, Sudan
Address reprint requests to
*Ibrahim Bakhit Yousif Elemam,
Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, Shendi University, Sudan
Background Prostatic adenocarcinoma is the most PREVALENT cancer and the second cause of cancer related death among men; the tumour proliferative activity is difficult to measure histologically. Increasing EVIDENCE suggests that the factors controlling cell cycle progression also modulate the rate of ribosome biogenesis; and can assess the proliferative activity.The present study aimed to assess the proliferation activity in prostate cancer.
Materials and Methods A total of 40 various prostatic lesions were studied, 20 cases of prostatic adenocarcinomas (study group) and 20 cases of benign prostatic hyperplasia (BPH) as (control group). Sections of 3-μ thickness was obtained from each formalin-fixed paraffin-embedded tissue block using rotary microtome and it was stained using haematoxylin and eosin (Mayer’s technique) and AgNOR stains.Results The majority of patients with BPH and prostate adenocarcinoma were in their sixth to eighth decade of life. The BPH samples displayed fewer AgNORs (mean 2.0 dots/cell) compare to adenocarcinomas (mean 4.1 dots/cell), p value was (0.001). Therefore this data indicate that analysis of silver staining-positive material in intact interphase cells may help distinguish between benign and malignant prostatic tumours.Conclusions AgNOR have a value in distinguishing between BPH and adenocarcinoma of the prostate.
KEYWORDS Fprostate, carcinoma, prostatic hyperplasia, AgNORs
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Review article
Seyed Sajjad Babaeimarzangou1, Shahin Aghajanshakeri1*,Dana Anousheh1,Peyman Mikaili2
1 Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
2 Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
Address reprint requests to
*Shahin Aghajanshakeri, Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Article citation: Babaeimarzangou SS,Aghajanshakeri SH, Anousheh D, Mikaili P. Ethno-botanical, Bioactivities and Medicinal Mysteries of Fumaria officinalis (Common Fumitory). J Pharm Biomed Sci 2015;05(11):857–862. Available at www.jpbms.info
Abstract
Fumaria officinalis (of Fumariaceae family) is a well-known traditional herb rich in biochemically active components. F. officinalis (common fumitory or earth smoke) is the most common species of the genus Fumaria in Western and Central Europe. Fumitory was officially recognised in 1986 by the French Health authorities as an herbal medicine which was traditionally used in renal and digestive elimination functions. By accurately looking to the name of fumitory, it is said to be derived either from the fact that its whitish,
blue-green colour gives it the appearance of smoke rising from the ground, or according to Pliny and Olivier de Serres (XIV century) because the juice of the plant brings on such a flow of tears that the sight becomes dim as with smoke and hence its reputed use in affections of the eye. This herb has been known since antiquity and was described in herbals from the Middle-Ages. It was mainly the Mediterranean genus which was once used as medicine and wound healing. In a meanwhile traditionally fumarity has been used as digestive and diuretic.
KEYWORDS Fumaria officinalis, Fumariaceae, ethno-botanical, herbal medicine,fumarity, pharmacological effects
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Acknowledgement: The authors are grateful to all the people who helped them through the
process and all organizations which did not withhold any efforts for better handling of this
research.