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Case report
Anjana Chaudhary1,Sunita Chandrakar2,Diwakar RK3*,Meena Naik1
1 Department of Obstetrics & Gynaecology,C. M. Medical College & Hospital, Kachandur, Durg (C.G.), India
2 Department of Pharmacology, C. M.Medical College & Hospital, Kachandur, Durg (C.G.), India
3 Department of Radiodiagnosis, C. M.Medical College & Hospital, Kachandur, Durg (C.G.), India
Abstract:
Although the incidence of allergic reactions to local anaesthetics has decreased, they are still documented. Allergic reactions may consist of cutaneous lesions, urticaria, oedema or anaphylactic reactions. Severe hypersensitive reaction to local infiltration resulting in thin, charred and parchment-like skin with subsequent granuloma formation requiring debridement has not been reported earlier. We report a case of severe local skin reaction to lignocaine which is known to contain methylparaben as a preservative.
KEYWORDS hypersensitivity reaction, local anaesthetic agent, methylparaben
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*Diwakar RK, Department of Obstetrics & Gynaecology, Radio-diagnosis, C. M. Medical College & Hospital, Kachandur,Durg (C.G.), India
Article citation: Chaudhary A, Chandrakar S, Diwakar RK, Naik M. Severe skin hypersensitivity reaction to local infiltrating anaesthetic agent. J Pharm Biomed Sci2015;05(11):848–850.Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Case report
Renuka Jadhav*, Shradha Lohiya, Sharad Agarkhedkar, Anita Lohakare, Shradha Salunkhe
Department of Pediatrics. Dr. D. Y. Patil Medical College, Hospital and Research Centre (D. Y. Patil University Pune) Pimpri, Pune 411018, India
Abstract:
Background Dengue haemorrhagic fever (DHF), a potential lethal complication affects the Asian countries and has become a leading cause of hospital admissions and death among children. Dengue with its severe manifestations of DHF and dengue shock syndrome (DSS) has emerged as a major public health problem of international concern.
Aims To identify the predictive factors for spontaneous bleeding manifestations in dengue illness in children. To determine the utility of haematological parameters as diagnostic markers of dengue haemorrhagic fever.
Materials and Methods This is a prospective, cross-sectional study. Eighty patients (1–12 years) with proven diagnosis of dengue by NS1 were enrolled. Patients were DIVIDED into two groups: DHF group and DF group. A detailed history, clinical examination, with laboratory parameters was done in all patients. Data was analysed using SPSS Version 7 by applying the appropriate tests.
Results Dengue showed a seasonal trend, maximum number of cases (44 cases) were seen in September and October in 2012. Fever (100%), rash (62.5%), vomiting (60%), and abdominal pain (31.25%) were common features. Bleeding manifestations were petechiae and purpura 60.62%, melena was 40.63%, epistaxis was 15.63%, haematemesis was 3.12% and subconjuctival haemorrhage was 3.12%. Abdominal pain (31.25%), tender hepatomegaly (57.5%), and positive tourniquet test were significantly associated withspontaneous bleeding. Low platelet count was significantly associated with spontaneous bleeding but thrombocytopenia alone could not predict spontaneous bleeding.
Conclusion Clinical criteria as such as abdominal pain, tender hepatomegaly, and positive tourniquet test along with the laboratory parameters such as haemoconcentration, low platelet count, abnormal serum levels of liver enzymes, and prolonged prothrombin time were significantly associated in predicting spontaneous bleeding and these predictors of spontaneous bleeding can help the clinician to anticipate the problem, prognosticate,decide the need of referral to higher centre for monitoring, managing and blood product transfusion when required, thus limiting the morbidity and mortality.
KEYWORDS dengue, dengue haemorrhagic fever (DHF), dengue shock syndrome (DSS)
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Dr. Renuka Jadhav, Professor, Department of Pediatrics Dr. D. Y. Patil Medical College, Hospital and Research Centre (D. Y. Patil University Pune), Pimpri, Pune 411018, India
Article citation: Jadhav R, Lohiya S,Agarkhedkar S, Lohakare A, Salunkhe S. Study of dengue fever with special reference to predictors of spontaneous bleeding in dengue infection. J Pharm Biomed Sci 2015;05(11):851–856. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.