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Original Article
Rahul Ravindra Bagul1*, Utkarsha Joshi2, Vikram Kakatkar3, Sanjay Deo4
1 Associate Professor, Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
2 Assistant Professor, Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri,Pune, India
3 Senior Resident, Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
4 Professor, Department of Orthopaedics,Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
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*Dr. Rahul R. Bagul, Department of Orthopaedics,Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India
Article citation: Rahul B, Utkarsha J,Vikram K, Sanjay D. Comparative study of management of proximal humerus fractures in elderly by conservative method Versus operative locking compression plate. J Pharm Biomed Sci 2015;05(11):831–838.
Abstract:
Background Proximal humeral fracture in patients more than 65 years old, represent the third most common fracture. Treatment of proximal humerus fractures, especially displaced fractures, remains controversial. Conservative treatment has been preferred for most of the undisplaced or minimally displaced fractures. Over the years, availability of improved fixation devices, popularised the treatment of these fractures by open reduction and internal fixation. Operative treatment of proximal humerus fractures poses a challenge because of complications like malunion, non-union and avascular necrosis.Objective To study the role of conservative treatment and operative treatment by locking compression plate in the management of these fractures. To compare the results ofconservative management Versus locking plate osteosynthesis. To EVALUATE the results of treatment in terms of clinical and radiological union as well as functional outcome.
Materials and methods In the present case study, we report our experience in 60 cases in whom comparative study of management of proximal humerus fractures in elderly by conservative method Versus operative locking compression plate was done.Results As measured by Neer’s shoulder score, out of the 60 cases in our study, 8 (13.33%) had excellent functional outcome out of which 3 were treated conservatively and 5 were treated operatively, 29 (48.33%) had satisfactory outcome out of which 14 were treated conservatively and 15 were treated operatively, 19 (31.67%) had unsatisfactory outcome out of which 10 were treated conservatively and 9 were treated operatively, and 4 (6.67%) cases were failures out of which 3 were treated conservatively and 1 were treated operatively.
KEYWORDS proximal humerus fracture, old age, locking compression plate, conservative treatment
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in
discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Original article
Jayanta Kumar Barua1, Mausumi Basu2,Susmita Bhattacharya3, Kheya Mukherjee4, Debasish Sinha5, Anita Nandi6
1Assistant Professor, Department of Dermatology, Venerology and Leprosy,The School of Tropical Medicine, Kolkata
2Associate Professor, Department of Community Medicine, IPGME&R and SSKM Hospital, Kolkata
3 Professor and 4Assistant Professor, Department of Microbiology, N.R.S. Medical College and Hospital, Kolkata
5 Assistant Professor, Department of Community Medicine, IPGME&R/ SSKM Hospital, Kolkata
6 Assistant Professor, Department of Microbiology,Medical College and Hospital, Kolkata
The name of the department(s) and institution(s) to which the work should be attributed: NRMC & H,Kolkata adjacent to attributed.
Address reprint requests to
*Dr. Mausumi Basu,
Associate Professor,Department of Community Medicine, IPGME&R and SSKM Hospital, Kolkata, India
Article citation: Barua JK, Basu M, Bhattacharya S, Mukherjee K, Sinha D, Nandi A. Epidemiological profile of HIV patients in a tertiary care hospital of Kolkata. J Pharm Biomed Sci 2015;05(11):890–896. Available at www.jpbms.info
Abstract:
Background Approximately 20.89 lakh people were living with HIV/AIDS (PLHA) in India in 2011 with prevalence rate of 0.27%. Objectives To assess the prevalence of HIV among consented attendees and to analyse the epidemiological profile of HIV-positive clients diagnosed in an ICTC of Kolkata. Materials and Methods A descriptive cross-sectional study was carried out throughthe analysis of secondary data from July 2012 to June 2013 in an ICTC centre attached with microbiology department of a medical college, Kolkata; using a pre designed proforma. Data were analysed using Epi Info version 3.5.1 and Statistical Package for Social Sciences (SPSS 22.0) software version. Results Counseling and testing services were provided to 14,679 clients; 158 were diagnosed as HIV positive with a prevalence of 1.07%; about 89.24% of seropositives belonged to age group of 15–49 years; males constituted 68.99%; 54.43% HIV were from rural area; 56.33% were married; literacy rate was 83.55%; 65.31% females were housewives; 39.8% of male clients undertook daily wage; 28.48% had sexual partner who were positive for HIV; 93.04% practiced high risk behaviour;78.48% acquired HIV through heterosexual route; 08.86% and 06.33% were involved in homosexual and bisexual practices respectively; and parent to child transmission rate was 5.70%. Conclusions This study provides an important clue to understand the epidemiology of HIV/ AIDS in a particular geographic region and to help an effective local planning for care, treatment and support of those infected and preventive strategies for those who are at risk.
KEYWORDS HIV positive clients, risk behaviour, ICTC, epidemiological profile
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Review article
Seyed Sajjad Babaeimarzangou1, Shahin Aghajanshakeri1*,Dana Anousheh1,Peyman Mikaili2
1 Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
2 Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
Address reprint requests to
*Shahin Aghajanshakeri, Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Article citation: Babaeimarzangou SS,Aghajanshakeri SH, Anousheh D, Mikaili P. Ethno-botanical, Bioactivities and Medicinal Mysteries of Fumaria officinalis (Common Fumitory). J Pharm Biomed Sci 2015;05(11):857–862. Available at www.jpbms.info
Abstract
Fumaria officinalis (of Fumariaceae family) is a well-known traditional herb rich in biochemically active components. F. officinalis (common fumitory or earth smoke) is the most common species of the genus Fumaria in Western and Central Europe. Fumitory was officially recognised in 1986 by the French Health authorities as an herbal medicine which was traditionally used in renal and digestive elimination functions. By accurately looking to the name of fumitory, it is said to be derived either from the fact that its whitish,
blue-green colour gives it the appearance of smoke rising from the ground, or according to Pliny and Olivier de Serres (XIV century) because the juice of the plant brings on such a flow of tears that the sight becomes dim as with smoke and hence its reputed use in affections of the eye. This herb has been known since antiquity and was described in herbals from the Middle-Ages. It was mainly the Mediterranean genus which was once used as medicine and wound healing. In a meanwhile traditionally fumarity has been used as digestive and diuretic.
KEYWORDS Fumaria officinalis, Fumariaceae, ethno-botanical, herbal medicine,fumarity, pharmacological effects
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Acknowledgement: The authors are grateful to all the people who helped them through the
process and all organizations which did not withhold any efforts for better handling of this
research.
Research article
Kun Zhang1,Jiayu Gao2,Zaijun Zhang3*
1Institute of New Drug Research and Guangdong PROVINCE Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy,Guangzhou 510632 China
2Institute of New Drug Research and Guangdong PROVINCE Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China
Abstract:
This study was designed to investigate the difference between three 6-hydroxydopamine(6-OHDA)-induced rat PD models. Those rats model were established by stereotaxic unilateral 6-OHDA injection into different parts of nigrostriatal pathway including the striatum (ST), the substantia nigra pars compacta (SNPc) and the Ventral tegmental area (VTA) in left side of rat brain. To detect pathological change in the unilaterally lesion 6-OHDA rats,the intact hemisphere work as a internal control. Immunohistochemical staining was used to EVALUATE the expression of tyrosine hydroxylase (TH) in substantia nigra pars compacta, as indication of injure of dopaminergic neuron. Remarkable TH-postive neuron loss was found in substantia nigra pars compacta in all 6-OHDA injected groups.the steep depletion of the content of dopamine and its metabolites of in striatum was also observed in all 6-OHDA injected groups. The 6-OHDA-impaired rats demonstrate a decrease of body weight compared to sham group rats. Behavioral assessments of motor impairments in the unilateral 6-OHDA rat model were done by apomorphine-induced rotation tests. in apomorphine-induced contralateral rotations test,the ST injection group show increasing rotation from the 2th week to the 4th week and high success rate of modeling; SNpc group and VTA + SNpc groups showed stable rotations from the 2nd week but low success rate. These results suggested that ST group has higher success rate and is more practicable than the other two groups.
Article citation: Zhang K, Gao JY, Zhang ZJ. EVALUATION OF PARKINSON’S DISEASE IN 3 RAT MODELS INDUCED BY THREE DIFFERENT UNILATERAL INJECTIONS OF 6-HYDROXYDOPAMINE. J Pharm Biomed Sci 2015;05(11):842–847.Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research,patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Research Article.
Erika Teresa Quintana1*,Diana Andrea Gil-Rivera1,Amanda Alejo-Viderique1,Oliver López-Villegas1, Luis Ángel Maldonado2,3
1 Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN),México DF, México
2 Facultad de Química, Universidad Nacional Autónoma de México (UNAM), México DF,México
3 Rectoría – Secretaría General, Universidad Autónoma Metropolitana (UAM), México DF, México
Address reprint requests to
*E. T. Quintana,
Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), México DF, México
Article citation: Quintana ET, Gil-Rivera DA, Alejo-Viderique A, López-Villegas O,Maldonado LA. Evaluation of the antifungal and antiyeast activities from recently isolated Streptomycetes. J Pharm Biomed Sci 2015;05(11):867–876. Available at www.jpbms.info
Abstract: The indisputable role of Actinobacteria (aka “actinomycetes”) in the pharmaceutical industry is represented by its innate capability to produce antibiotics, but little is known about the antifungal compounds they could also be producing. Among the Actinobacteria,the genus Streptomyces produces antagonistic molecules against several pathogenic fungi and search/discovery programs should be revisited due to novel and/or poorly studied fungal emerging diseases in humans and plants. In humans, this is certainly important because novel antifungal therapies are among the most challenging problems in intensive care medicine. The present study focused on the isolation and identification of novel organisms of the genus Streptomyces and their evaluation for antifungal activities.
One hundred actinomycetes were isolated from Mexican soil samples and identified by using two pairs of specific primers: (a) a pair of primers for the class Actinobacteria and (b) for the family Streptomycetaceae; all the isolates selected were found to contain LLA 2pm in their cell walls, a-wall chemical marker for Streptomyces. The isolates were thenassigned to 38 multimembered groups on the basis of their morphological properties and one representative of each subgroup tested on in vitro antibiosis methods for
antifungal–antiyeast activities. 97.4% and 81.6% of the isolates showed activity against the type strains of Aspergillus niger and Candida albicans, respectively. 16S rRNA gene sequencing of five isolates showed that they are closely related among each other and felt in the Streptomyces griseus subclade which is highly heterogeneous; the isolates may well represent novel species showing both antifungal and antiyeast activities, a property not fully explored for members of that Streptomycetes 16S rRNA gene subclade.
KEYWORDS Actinomycetes, Streptomyces, antifungal activities, Aspergillus niger,Candida albicans
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: ETQ CONACyT Jóvenes Talentos SIP-2015-RE/057-CONACYT C110/2015 and SIP20150292.