DocumentsDate added
Case Report
Sanjeev Kumar Salaria1,Navjot Kaur Chahal2*,Surinder S Chahal3,Prabhdiljit Singh4
1 Head of Department, Department of Periodontology and Oral Implantology,Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
2* Post graduate student, Department of Periodontology and Oral Implantology,Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
3 Post graduate student, Department of Conservative Dentistry & Endodontics,Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
4 Intern, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
Address reprint requests to
*Dr. Navjot Kaur Chahal,
Post graduate student, Department of Periodontology and Oral Implantology, Surendera Dental College and Research Institute, Sri Ganganagar,Rajasthan, India
Article citation: Salaria SK, Chahal NK, Chahal SS, Singh P. Single flap approach with lingual access in conjugation with PRF and Biograft HABG for the management of residual grade II furcation defect occurring from primary endodontic with secondary periodontal lesion:an interdisciplinary case report. J Pharm Biomed Sci 2016;06(01):18–22. Available at www.jpbms.info
ABSTRACT
The success of an endodontic and periodontal lesion depends on the elimination of both of these disease processes; as the endodontic therapy results in healing of the endodontic component of involvement while the prognosis or outcome of tooth would finally depend on the healing of the periodontal structures. In this case report, a residual grade II furcation defect of primary endodontic with secondary periodontal lesion was managed by endodontic therapy followed by periodontal regenerative therapy with BioGraft® hydroxy apatite active bone graft (HAGB) and platelet rich fibrin (PRF) utilizing single flap access technique. At 6 months post operatively there was reduction in periodontal pocket and gain in clinical attachment level with complete regeneration in grade II furcation bone defect was observed without any post operative complication.
KEYWORDS endo-perio lesion, residual grade II furcation, root canal therapy, periodontal regeneration, single flap access.
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents,and royalties through this collaborative research.
All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
REVIEW ARTICLE
Mitul Mishra1*,Prachi Mishra2,Vaibhao Shambharkar3,Amber Raut4
1 Assistant Professor, SDKS Dental College & Hospital, Hingna, Nagpur, India
2 Private Practitioner, Nagpur, India
3 Assisant Professor, SDKS Dental College & Hospital, Nagpur, India
4 Assistant Professor, SDKS Dental College & Hospital, Hingna, Nagpur, India
Address reprint requests to
*Dr. Mitul K Mishra,
Department of Periodontics, SDKS Dental College and Hospital, Hingna, Nagpur, India
Article citation: Mishra M, Mishra P, Shambharkar V, Raut A. Scaffolds in periodontal regeneration. J Pharm Biomed Sci 2016;06(01):10–17.
Available at www.jpbms.info
ABSTRACT
Periodontal tissue engineering requires triad of cells, inductive component and a scaffold on
which growth can occur. Previously periodontal treatment was aimed to selectively repopulate the defect site with cell that has capability to regenerate lost tissue by using the
concept of guided tissue regeneration. However, this technique is not always possible. Use of scaffolds that can also deliver cells required for regeneration to occur is relatively a newer concept. A biomaterial is defined as a nonviable material used in a medical device, intended
to interact with biological systems. For a device to be effective, it has to meet certain criteria
based on organ and tissue properties and specific goals. Every material available in market has its own advantages and disadvantages. This review will mainly focus on the devices along with the advancement taking place related to cell delivery system.
KEYWORDS regeneration, tissue engineering, scaffold, cell delivery system.
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents,and royalties through this collaborative research.
All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
Original article
Swyeta Jain Gupta1,*,Amit Gupta2,Vivek Gautam3,Kaushik Kumar Pandey4,Swati Choudhary5
1 Senior Lecturer, Department of Periodontics and Implantology, I.T.S. Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India
2 Senior Lecturer, Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Dental College, Hospital and Research Centre, Greater Noida,Uttar Pradesh, India
3 Prosthodontics (Private practitioner), Gautam Multispeciality Dental Clinic, P N Plaza Complex, Sigra, Varanasi,Uttar Pradesh, India
4 Department of Prosthodontics Career Postgraduate Institute of Dental Science and Hospital, Lucknow, Uttar Pradesh,India
5 Oral and Maxilllofacial Pathology, Delhi, India
Address reprint requests to
*Dr. Swyeta Jain Gupta,
Senior Lecturer,Department of Periodontics and Implantology,I.T.S. Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India
Article citation: Gupta SJ, Gupta A,Gautam V, Pandey KK, Choudhary S. RNA interference: an evolutionary pathway in periodontal tissue engineering. J Pharm Biomed Sci 2016;06(01):39–43. Available at www.jpbms.info
ABSTRACT
RNA interference (RNAi) is an evolutionary conserved silencing pathway in which the double-stranded RNA is broken down into small interfering RNA (siRNA) with the help of dicer and RNA-induced silencing complex (RISC) complex by a series of steps. Pioneering observations on RNAi were reported in plants, but later on RNAi-related events were described in almost all eukaryotic organisms, including protozoa, flies, nematodes, insects, parasites, and mouse and human cell lines.
KEYWORDS gene silencing, RNAi, DICER, RISC
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes
that the manuscript represents honest and original work.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Kiran Madhusudhan1*, Pujita B2
1 Professor of Microbiology, Sree Balaji Medical College & Hospital, Bharath University, Chennai
2 PG, Department of ENT, Sri Ramachandra Medical College & Hospital, Sri Ramachandra University, Chennai
Address reprint requests to
*Kiran Madhusudhan, Sree Balaji Medical College & Hospital, Bharath University,Chennai
Article citation: Kiran M, Pujita B. Review on pressure sores. J Pharm Biomed Sci 2016;06(01):44–46.Available at www.jpbms.info
ABSTRACT
Pressure sore is a localised injury to the skin and underlying tissue caused due to unrelieved pressure on pressure points or bony prominences. The predisposing factors causing pressure ulcers are both intrinsic and extrinsic. Patients who are generally at risk, are those confined to bed or chair and unable to move without help. According to NPUAP (National pressure ulcer advisory panel), pressure ulcers can be categorised into four stages, and an unstageable category also exists. Staging helps to select the mode of treatment. Diagnosis is mainly by MRI, bone scan, bone biopsy and blood culture, if necessary. As the cost of treatment and complications due to pressure sores increase with the period of stay, it is better to adopt preventive methods strictly to “at risk” patients. Prevention includes, identification of “at risk” patients using the three risk assessment scales and follow interventions to reduce the risks. Goals of treatment consist of resolution of infection, promotion of wound healing and effective infection control and in advanced stages, use of newer approaches like negative pressure wound therapy (VAC therapy-vacuum-assisted closure) and surgery.
KEYWORDS pressure sore, capillary pressure, intrinsic and extrinsic risk factors,staging, sepsis, osteomyelitis, negative pressure therapy (VAC), risk assessment scales
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes
that the manuscript represents honest and original work.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Dewi Oktavia1,2, Dyah Aryani Perwitasari1*, Woro Supadmi1
1 Faculty of Pharmacy, University of Ahmad Dahlan, Yogyakarta, Indonesia
2 Sentosa Mother and Children Hospital Bogor, Indonesia
Address reprint requests to
Dyah Aryani Perwitasari, Pharmacy Faculty, Ahmad Dahlan University,Yogyakarta, Indonesia
Article citation: Oktavia D, Perwitasari DA, Supadmi W. Quality-adjusted life years (QALYs) of tuberculosis patients in the intensive and continuous phase in a private hospital of Yogyakarta, Indonesia. J Pharm Biomed Sci 2016; 06(01):27–30.Available at www.jpbms.info
ABSTRACT
Context Tuberculosis is a disease with low quality of life (QoL) and quality-adjusted life years (QALYs) due to illness, impairment of health conditions and death. QALYs combine the QoL as well as quantity of life with value judgments utility of individuals or society. Aims To compare the QoL and QALYs of tuberculosis patients between treatment on the intensive and the continuous phase. Settings and Design This study used cohort design in a private hospital of Yogyakarta.Subjects were patients with newly diagnosed pulmonary tuberculosis and aged between 20 and 80 years. Materials and Methods Data was collected using Indonesian version of St. George Respiratory questionnaire (SGRQ) and using the scenario time trade off method (TTO) at the end of 1st , 2nd , and , 3rd month treatment. The score obtained was used to measure patients’ QoL and QALYs during the treatment phase.Statistical Analysis To determine the differences of QoL and QALY in the intensive and continuous phase we used the paired samples t-test. Results The average score of total QoL of tuberculosis patients using the SGRQ was 45.90% in intensive phase and 17.43% in the continuous phase (p < 0.05). While the average of QALYs values was 0.74 QALYs in intensive phase and 0.87 in the continuous phase (p < 0.05).Conclusions Patients with pulmonary tuberculosis undergoing treatment with oral antituberculosis gain 0.74 QALY in the intensive phase and 0.87 QALY in continuous phase. Tuberculosis patients’ QoL and QALY are better in the continuous phase than ones in the intensive phase.
KEYWORDS QALY, quality of life, tuberculosis, Indonesia
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.