DocumentsDate added
Original article
Chongwei Chen1, Guohua Cheng2*
1 Candidate for degree of master in Clinical Pharmacy, School of Pharmacy, Jinan University, 601 Huangpu Avenue West,Guangzhou, China, P.C. 510632
2 Professor, School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China, P.C. 510632
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*Guohua Cheng,
Jinan University, 601 Huangpu Avenue West, Guangzhou,China, P.C. 510632
Article citation: Chen C, Cheng G. Nedaplatin plus docetaxel in the treatment of advanced oesophageal cancer: a retrospective study in China. J Pharm Biomed Sci 2016;06(03):255–258.Available at www.jpbms.info
ABSTRACT
Background Currently, there is no standard chemotherapy for advanced oesophageal cancer, especially for those with recurrent or metastatic one.
Objective To retrospectively investigate the efficacy and safety of combination of nedaplatin with docetaxel in the treatment of Chinese patients with advanced oesophageal cancer.
Methods Patients with advanced oesophageal cancer from two specialist hospitals in Guangzhou received intravenously 60 mg/m2 docetaxel for 1 h, followed by 80 mg/m2 nedaplatin for 2 h, on day 1 for every 28 days. Cycles continued until documented disease progression, unacceptable toxicity or patient’s refusal. Kaplan–Meier analysis was used to estimate survival time.
Results Between 2008 and 2013, 368 patients were enrolled into the study. A total of 26 patients achieved complete response and 170 patients achieved partial response. The
median of progression-free survival and overall survival were 4.4 months and 8.8 months, respectively. The non-hematological toxicities were generally mild to moderate; severe hematological toxicities included neutropenia and anaemia, which observed in 85 (23.1%) patients and 112 (30.4%) patients; thrombocytopenia was mild (mostly Grade1); there were no febrile neutropenia and treatment-related death.
Conclusions The combination regimen of nedaplatin with docetaxel is effective and safe.
Keywords chemotherapy, docetaxel, oesophageal cancer, nedaplatin, retrospective study
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
ORIGINAL ARTICLE
S. Naveen1*,B. N. Lenka2,Alin Kumar Nayak1
1 Third Year PG Student, Department of General Surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
2 Assistant Professor, Department of General Surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
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*Dr S. Naveen, Third Year PG Student,Department of General Surgery,Hi-Tech Medical College and Hospital,Bhubaneshwar, Odisha, India
Article citation: Naveen S, Lenka BN,Nayak AK. A clinical study of secondary haemorrhoids and its management. J Pharm Biomed Sci 2016;06(03): 238–240. Available at www.jpbms.info
ABSTRACT
Background Haemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of haemorrhoids is rectal bleeding associated with bowel movement. The abnormal dilatation and distortion of the vascular channel, together with destructive changes in the supporting connective tissue within the anal cushion, is a paramount finding of haemorrhoids. In most instances, haemorrhoids are treated conservatively using many methods such as lifestyle modification, fibre supplement, suppository, anti-inflammatory drugs and administration of venotonic drugs. Non-operative approaches include sclerotherapy and rubber band ligation. An operation is indicated when non-operative approaches have failed or complications have occurred. Several surgical approaches for treating haemorrhoids have been introduced including haemorrhoidectomy and stapled haemorrhoidopexy.
Materials and Methods Clinical study of secondary haemorrhoids and its management were collected from cases admitted in Hi-Tech Medical College and Hospital, Bhubaneswar,
Odisha, during the period from 1st January 2014 to 31st December 2015.
Results The study was conducted on 50 cases who were admitted in Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha with features of secondary haemorrhoids.
Conclusions In this study, we assess the common causes of secondary haemorrhoids and its management.
KEYWORDS secondary haemorrhoids, haemorrhoidal plexus, banding, haemorrhoidectomy (closed and stapled), bowel care, sitz bath
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest:The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript. The first two authors contributed equally to the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
CLINICAL CASE
Anna Makhneva1,Yelena Kustova2*,Natalya Urazalieva3,Gulnara Abdilova4
1 Researcher, Laboratory of Pathomorphology, Almaty, Kazakhstan
2 Senior Researcher, Laboratory of Immunology, Science Center of Pediatrics and Children Surgery, Ministry of Health of the Republic of Kazakhstan, Al-Farabi av. 146, Almaty, Kazakhstan, 050040
3 Laboratory of Immunology, Almaty,Kazakhstan
4 Head of Oncogematology Department,Almaty, Kazakhstan
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*Yelena Kustova, PhD,
Researcher,Laboratory of Immunology, Science Center of Pediatrics and Children Surgery, Ministry of Health of the Republic of Kazakhstan, Al-Farabi av.146, Almaty, Kazakhstan, 050040
Article citation: Makhneva A, Kustova Y,Urazalieva N, Abdilova G. Myelofibrosis case in a child. J Pharm Biomed Sci 2016;06(03):241–243. Available at www.jpbms.info
ABSTRACT
Complexity myelofibrosis diagnosis at an early stage is that it takes place under other conditions mask: anaemia, abdominal pain, enlarged liver and spleen. This article describes
a case of myelofibrosis in a child, when the diagnosis was made late, which resulted in a poor prognosis.
KEYWORDS myelofibrosis, myeloproliferative disorders, acute myeloid leukemia
REFERENCES
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest:The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript. The first two authors contributed equally to the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
ORIGINAL ARTICLE
Huan Chen1,2,Yi-Fang Li1,Chong Jie1,Hiroshi Kurihara1,2,Rong-Rong He1*
1Institute of Traditional Chinese Medicine and Natural Products, Jinan University,Guangzhou, China
2 Changsha Medical University, Changsha,China
Address reprint requests to
*Rong-Rong He, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
Article citation: Chen H, Li YF, Jie C,Kurihara H, He RR. Effects of chicken extract on 5-HT level in mice loaded with restraint stress. J Pharm Biomed Sci 2016;06(03):244–249.Available at www.jpbms.info
ABSTRACT
Chicken extract (CE), which is composed of water-soluble substances extracted from chicken by double boiling, could enhance mental efficiency and are helpful to the recovery from postpartum sickness and mental fatigue. But, little information is available regarding its underlying mechanisms. 5-hydroxytryptamine (5-HT), as a central neurotransmitter, involves in various functional changes of brain. In our study, we studied the effects of CE on 5-HT level in restraint-stressed mice. Male Kunming mice were randomly divided into four groups as follows: normal, restraint stress, restraint stress + 12 mL/kg/d CE (CE-L),
restraint stress + 24 mL/kg/d CE (CE-H). On the 14th day of administration, all mice were physically restrained in a 50 mL polypropylene centrifuge tube with holes for 18 h except for normal group. All mice were diethyl ether-anesthetised, 1 day after restraint stress and their brains were obtained for reverse transcription polymerase chain reaction. The levels of 5-HT in plasma, cerebral cortex and hippocampus were also determined by high performance liquid chromatography with an electrochemical detection. The results showed that CE could recover the changed levels of 5-HT in brain or plasma induced by restraint stress, the mechanism may be related to its modulation on tryptophan hydroxylase activity.
KEYWORDS chicken extract; 5-hydroxytryptamine (5-HT); restraint stress
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest:The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript. The first two authors contributed equally to the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
Original article
Wen-Shan Huang1,Yi-Fang Li1,Huan Chen1,Ting-Mei Wang1,Hiroshi Kurihara1,2, Rong-Rong He1,2*
1Anti-Stress and Health Research center,College of Pharmacy, Jinan University, Guangzhou, China
2Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
Address reprint requests to
*Rong-Rong He,
Anti-Stress and Health Research center, College of Pharmacy,Jinan University, Guangzhou, China
Article citation: Huang WS, Li YF, Chen H, Wang TM, Kurihara H, He RR. The ameliorative effects of CE (a chicken extract) on learning and memory function of restraint-stressed mice. J Pharm Biomed Sci 2016;06(03):259–263. Available at www.jpbms.info
ABSTRACT
In this study, we studied the effects of Chicken Essence (CE) on learning and memory function of restraint-stressed mice. Male Kunming mice of 7-week-old were randomly divided into five groups as follows: normal control, restraint stress control, low dosage of CE (12 ml/kg/d, CE-L) and high dosage of CE (24 ml/kg/d, CE-H). The normal control group and restrain stress control group received water only. On the 14th day of administration,all mice were conducted to step through training, and physically restrained
in a 50 ml restrained tube with holes for 18 h except for normal control mice. All mice were conducted to step through testing, 1 day after restraint stress. All animals were anesthetized, their brains and blood were obtained. We determined the neuron protective transmitters, dopamine hydrochloride and norepinephrine level in brain and plasma via ESA–HPLC. The results showed that the administration of CE could improve the impaired function of learning and memory. Furthermore, it also recovered the changed levels of neurotransmitters in brain or plasma in restraint-stressed mice.
Keywords learning and memory; restraint stress; stress hormone
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.