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Research article
Suresh V Dange1, Shrikrishna Subhash Shende2*,Balchandra T Rane3,Abhijeet V Tilak4,Moh anish U Vaidya2,Manasi V Limaye2
1 MBBS, MD Pharmacology, DNB Family Medicine, Department of Pharmacology,Dr. D.Y. Patil Medical College, Pimpri, Pune,411018, India
2 MBBS MD, Junior Resident, Department of Pharmacology, Dr. D.Y. Patil Medical College, Pimpri, Pune, 411018, India
3 MBBS, Department of Pharmacology,Dr. D.Y. Patil Medical College, Pimpri,Pune, 411018, India
4 MBBS, MD Pharmacology, Department of Pharmacology, Dr. D.Y. Patil Medical College, Pimpri, Pune, 411018, India
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*Dr. Shrikrishna Subhash Shende,
Department of Pharmacology, Dr. D.Y. Patil Medical College, Pimpri, Pune 411018, India
Article citation: Dange SV, Shende SS,Rane BT, Tilak AV, Vaidya MU, Limaye MV. An observational study of the antidiabetic activity of berberine in newly diagnosed type 2 diabetes mellitus patients. J Pharm Biomed Sci 2016;06(03):230–233. Available at www.jpbms.info
Abstract:
Background Suboptimal glycemic control is a common situation in diabetes, regardless of the wide range of drugs available to achieve glycemic targets. There is in fact a growing body of literature on plants used for the treatment of diabetes. In this respect, in the past few years, attempts were made to use natural plant products for the treatment of patients with diabetes.
Berberine is a commonly available as a nutraceutical and it is a potential candidate for diabetes. Methods and Results A total of 30 newly diagnosed type 2 diabetes mellitus patients
were included in the study after obtaining their informed written consent. They were divided into two groups (n = 15 each), receiving either metformin 500 mg/12 h or berberine 500 mg/12 h p.o. for 12 weeks. No other antidiabetic drugs were given. Therapeutic life style measures were common in both groups. Physical examination and estimation of laboratory parameters were done at baseline and after 12 weeks. Laboratory parameters estimated were fasting blood glucose level (FBG), post prandial blood glucose level (PPBG), glycated hemoglobin (GHb), lipid profile, serum alanine transferase and serum creatinine. Berberine treatment significantly reduced FBG, PPBG, GHb levels and there was significant improvement in lipid profile. The results were comparable to those with metformin.
Conclusion Berberine (500 mg twice daily) may be a useful antidiabetic drug.
KEYWORDS antidiabetic activity, berberine, type 2 diabetes mellitus.
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Acknowledgement: The free samples of berberine (Berbeshine hydrochloride 500 mg) were provided by Akumentis Healthcare Ltd, Mumbai.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research.
All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
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ORIGINAL ARTICLE
S. Naveen1*,B. N. Lenka2,Alin Kumar Nayak1
1 Third Year PG Student, Department of General Surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
2 Assistant Professor, Department of General Surgery, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
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*Dr S. Naveen, Third Year PG Student,Department of General Surgery,Hi-Tech Medical College and Hospital,Bhubaneshwar, Odisha, India
Article citation: Naveen S, Lenka BN,Nayak AK. A clinical study of secondary haemorrhoids and its management. J Pharm Biomed Sci 2016;06(03): 238–240. Available at www.jpbms.info
ABSTRACT
Background Haemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of haemorrhoids is rectal bleeding associated with bowel movement. The abnormal dilatation and distortion of the vascular channel, together with destructive changes in the supporting connective tissue within the anal cushion, is a paramount finding of haemorrhoids. In most instances, haemorrhoids are treated conservatively using many methods such as lifestyle modification, fibre supplement, suppository, anti-inflammatory drugs and administration of venotonic drugs. Non-operative approaches include sclerotherapy and rubber band ligation. An operation is indicated when non-operative approaches have failed or complications have occurred. Several surgical approaches for treating haemorrhoids have been introduced including haemorrhoidectomy and stapled haemorrhoidopexy.
Materials and Methods Clinical study of secondary haemorrhoids and its management were collected from cases admitted in Hi-Tech Medical College and Hospital, Bhubaneswar,
Odisha, during the period from 1st January 2014 to 31st December 2015.
Results The study was conducted on 50 cases who were admitted in Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha with features of secondary haemorrhoids.
Conclusions In this study, we assess the common causes of secondary haemorrhoids and its management.
KEYWORDS secondary haemorrhoids, haemorrhoidal plexus, banding, haemorrhoidectomy (closed and stapled), bowel care, sitz bath
REFERENCES
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest:The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript. The first two authors contributed equally to the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
Case report
Samruddhi S. Metha1,Amit A. Mhapuskar2,Darshan Hiremutt3,Vidhya D. Kamble4,Shams Ul Nisa3*
1 PG Student, Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital,Pune, India
2 Professor and HOD, Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, India
3 Assistant Professor, Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, India
4 PG Student, Department of Periodontology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, India
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*Dr. Samruddhi S Metha, Postgraduate Student, Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital,Katraj, Pune, 411043, India
Article citation: Metha SS, Mhapuskar AA,Hiremutt D, Kamble VD, Nisa SU. Chronic parotid sialadenitis with sialectasis: diagnosis of case through CT sialography.J Pharm Biomed Sci 2016;06(03): 234–237.
ABSTRACT
Sialadenitis is an inflammation of the salivary glands commonly affecting the parotid gland. It may be subdivided into acute, chronic and recurrent forms. Inflammatory changes in the ducts of the salivary glands are referred to as sialadenitis. Salivary gland examination plays an important role in oral diagnosis as most of the systemic diseases involve salivary glands. Sialography is one of the oldest imaging procedures, as it is a simple chair side procedure, easy to perform and cost worthy. The symptoms of chronic sialadenitis include intermittent, often painful, unilateral parotid swelling that may or may not be associated with eating. Intra-oral examination shows pus emanating from the Stenson’s duct orifice by gently massaging the gland. Sialectasis is the sialographic appearance of dots or blobs of contrast medium within the gland caused by inflammation of the glandular tissue producing saccular dilatation of the acini. We here report a case of chronic parotid sialadenitis and role of sialography through computed tomography as an adjuvant in the diagnosis of sialectasis and also as a diagnostic and therapeutic aid. Glandular lavage was performed after 1 week with 60 ml of normal saline and ductal dilatation with saline pressure which helped to clear the mucus plug that formed in acute phase.
KEYWORDS sialadenitis, sialectasis, CT sialography.
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14.Abdel-Wahed N, Amer ME, Abo-Taleb NS. Assessment of the role of cone beam computed sialography in diagnosing salivary gland lesions. Imaging Sci Dent. 2013;43:17–23. Available at www.jpbms.info
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents,
and royalties through this collaborative research.
All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
ORIGINAL ARTICLE
Shanmugasamy K1*,Bhavani K1,Anandraj Vaithy K1,Narashiman R2,Dhananjay S Kotasthane3
1 MD, Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidhyapeeth University, Puducherry, India
2 MD, Emeritus Professor, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidhyapeeth University, Puducherry, India
3 MD, Professor and HOD, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidhyapeeth University, Puducherry, India
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*Dr. Shanmugasamy K, MD, Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, SBV University,Pillaiyarkuppam, Puducherry, 607402, India
Article citation: Shanmugasamy K,Bhavani K, Vaithy AK, Narashiman R,Kotasthane DS. Clinical correlation of upper gastrointestinal endoscopic biopsies with histopathological findings and to study the histopathological profile of various neoplastic and non-neoplastic lesions.
J Pharm Biomed Sci 2016;06(03):220–224.Available at www.jpbms.info
ABSTRACT
Background The pathological conditions of upper gastrointestinal tract (GIT) are responsible for a wide range of morbidity and mortality and are also most commonly encountered disorder in routine clinical practice. Endoscopic visualisation helps in clinical diagnosis, however,it often warrants histopathological correlation of biopsy specimen for accurate final diagnosis.
Aim and Objectives To determine the profile of histopathological lesions of upper GIT and to correlate the various histopathological lesions of upper GIT with age, sex and clinical presentation.
Materials and Methods The study was conducted in the Department of Pathology in Mahatma Gandhi Medical College and Research Institute, Puducherry on 115 upper gastrointestinal
endoscopic biopsies during the period of 1 year from January 2014 to December 2014. Brief clinical data were documented. The biopsies were examined for various inflammatory and neoplastic lesions. The findings were then correlated with the clinical parameters.
Results and Conclusion Among 115 cases studied, non-neoplastic lesions were more common in gastrointestinal pathological lesions. The prevalence of gastrointestinal pathology is more common among males around the fourth and fifth decades of life. Dyspepsia and dysphagia were the most significant presenting clinical features. Helicobacter pylori association was demonstrable in nearly one-fourth of chronic gastritis cases. In gastric region, adenocarcinoma was the commonest neoplastic conditions, whereas in the oesophagus, squamous cell carcinoma is the predominant. In duodenum, inflammatory lesions are more common than malignancy.
KEYWORDS endoscopy, histopathology, chronic gastritis, adenocarcinoma
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
ORIGINAL ARTICLE
Huan Chen1,2,Yi-Fang Li1,Chong Jie1,Hiroshi Kurihara1,2,Rong-Rong He1*
1Institute of Traditional Chinese Medicine and Natural Products, Jinan University,Guangzhou, China
2 Changsha Medical University, Changsha,China
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*Rong-Rong He, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
Article citation: Chen H, Li YF, Jie C,Kurihara H, He RR. Effects of chicken extract on 5-HT level in mice loaded with restraint stress. J Pharm Biomed Sci 2016;06(03):244–249.Available at www.jpbms.info
ABSTRACT
Chicken extract (CE), which is composed of water-soluble substances extracted from chicken by double boiling, could enhance mental efficiency and are helpful to the recovery from postpartum sickness and mental fatigue. But, little information is available regarding its underlying mechanisms. 5-hydroxytryptamine (5-HT), as a central neurotransmitter, involves in various functional changes of brain. In our study, we studied the effects of CE on 5-HT level in restraint-stressed mice. Male Kunming mice were randomly divided into four groups as follows: normal, restraint stress, restraint stress + 12 mL/kg/d CE (CE-L),
restraint stress + 24 mL/kg/d CE (CE-H). On the 14th day of administration, all mice were physically restrained in a 50 mL polypropylene centrifuge tube with holes for 18 h except for normal group. All mice were diethyl ether-anesthetised, 1 day after restraint stress and their brains were obtained for reverse transcription polymerase chain reaction. The levels of 5-HT in plasma, cerebral cortex and hippocampus were also determined by high performance liquid chromatography with an electrochemical detection. The results showed that CE could recover the changed levels of 5-HT in brain or plasma induced by restraint stress, the mechanism may be related to its modulation on tryptophan hydroxylase activity.
KEYWORDS chicken extract; 5-hydroxytryptamine (5-HT); restraint stress
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest:The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript. The first two authors contributed equally to the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.