DocumentsDate added
CLINICAL CASE
Anna Makhneva1,Yelena Kustova2*,Natalya Urazalieva3,Gulnara Abdilova4
1 Researcher, Laboratory of Pathomorphology, Almaty, Kazakhstan
2 Senior Researcher, Laboratory of Immunology, Science Center of Pediatrics and Children Surgery, Ministry of Health of the Republic of Kazakhstan, Al-Farabi av. 146, Almaty, Kazakhstan, 050040
3 Laboratory of Immunology, Almaty,Kazakhstan
4 Head of Oncogematology Department,Almaty, Kazakhstan
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*Yelena Kustova, PhD,
Researcher,Laboratory of Immunology, Science Center of Pediatrics and Children Surgery, Ministry of Health of the Republic of Kazakhstan, Al-Farabi av.146, Almaty, Kazakhstan, 050040
Article citation: Makhneva A, Kustova Y,Urazalieva N, Abdilova G. Myelofibrosis case in a child. J Pharm Biomed Sci 2016;06(03):241–243. Available at www.jpbms.info
ABSTRACT
Complexity myelofibrosis diagnosis at an early stage is that it takes place under other conditions mask: anaemia, abdominal pain, enlarged liver and spleen. This article describes
a case of myelofibrosis in a child, when the diagnosis was made late, which resulted in a poor prognosis.
KEYWORDS myelofibrosis, myeloproliferative disorders, acute myeloid leukemia
REFERENCES
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest:The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript. The first two authors contributed equally to the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
Original article
Chongwei Chen1, Guohua Cheng2*
1 Candidate for degree of master in Clinical Pharmacy, School of Pharmacy, Jinan University, 601 Huangpu Avenue West,Guangzhou, China, P.C. 510632
2 Professor, School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, China, P.C. 510632
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*Guohua Cheng,
Jinan University, 601 Huangpu Avenue West, Guangzhou,China, P.C. 510632
Article citation: Chen C, Cheng G. Nedaplatin plus docetaxel in the treatment of advanced oesophageal cancer: a retrospective study in China. J Pharm Biomed Sci 2016;06(03):255–258.Available at www.jpbms.info
ABSTRACT
Background Currently, there is no standard chemotherapy for advanced oesophageal cancer, especially for those with recurrent or metastatic one.
Objective To retrospectively investigate the efficacy and safety of combination of nedaplatin with docetaxel in the treatment of Chinese patients with advanced oesophageal cancer.
Methods Patients with advanced oesophageal cancer from two specialist hospitals in Guangzhou received intravenously 60 mg/m2 docetaxel for 1 h, followed by 80 mg/m2 nedaplatin for 2 h, on day 1 for every 28 days. Cycles continued until documented disease progression, unacceptable toxicity or patient’s refusal. Kaplan–Meier analysis was used to estimate survival time.
Results Between 2008 and 2013, 368 patients were enrolled into the study. A total of 26 patients achieved complete response and 170 patients achieved partial response. The
median of progression-free survival and overall survival were 4.4 months and 8.8 months, respectively. The non-hematological toxicities were generally mild to moderate; severe hematological toxicities included neutropenia and anaemia, which observed in 85 (23.1%) patients and 112 (30.4%) patients; thrombocytopenia was mild (mostly Grade1); there were no febrile neutropenia and treatment-related death.
Conclusions The combination regimen of nedaplatin with docetaxel is effective and safe.
Keywords chemotherapy, docetaxel, oesophageal cancer, nedaplatin, retrospective study
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
Review article
Navnita Singh1*,S. Savita2,K. Rithesh3,Shilpa Shivanand1
1Post Graduate Student, Department of Periodontology, Rajarajeshwari Dental College and Hospital, Bangalore, India
2Professor and HOD, Department of Periodontology, Rajarajeshwari Dental College and Hospital, Bangalore, India
3Reader, Department of Periodontology, Rajarajeshwari Dental College and Hospital, Bangalore, India
Address reprint requests to
*Dr Navnita Singh, Post Graduate Student, Department of Periodontology, Rajarajeshwari Dental College and Hospital, #14, Ramohalli Cross, Kumbalgodu, Mysore Road, Bangalore, 560074, India
Article citation: Singh N, Savita S, Rithesh K, Shivanand S. Phytotherapy: a novel approach for treating periodontal disease. J Pharm Biomed Sci 2016;06(03):205–210.Available at www.jpbms.info
ABSTRACT
Over the years, periodontal therapy has been influenced by the trends of the times, and consequently treatment approaches have been modified. Our understanding of the etiology and diagnosis of the periodontal diseases is continuously evolving. Periodontitis caused by various microorganisms is often treated with common antibiotics. But antibiotic resistance is a growing problem. Thus, the global need for an alternative prevention and treatment options arises which is safe, effective and economical. So, researchers are in pursuit for new therapeutic agents from natural sources. There is a long and venerable history of the use of plants to improve dental health and promote oral hygiene. Plants contain phytochemicals such as alkaloids, tannins, essential oils and flavonoids which have pronounced antimicrobial activity. Because of its good antimicrobial activity and safety profile, it proves its use in the treatment of periodontal diseases. This suggests a potentially valuable role for phytotherapy in assisting with the management of this serious disease. The evidence and research which supports such a role for plants (or plant products) are reviewed in this study.
KEYWORDS periodontitis, antibiotic resistance, plant extracts
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
Gulab Kanwar1,Kshetrapal Singh Shekhawat2*,Shalini Rathore3,Kusum Bala Jain2
1MD, Professor and HOD, Department of Biochemistry, Government Medical College,Kota, Rajasthan, India
2PG Resident, Department of Biochemistry,Government Medical College, Kota,Rajasthan, India
3 MD, Goverment Jaipuria Hospital, Jaipur,Rajasthan, India
ABSTRACT
India is being called the diabetic capital of the world, with over 30 million diabetic individuals. Anthropometric parameters have evolved into reliable indicators for predicting the incidence of diabetes mellitus.
Materials and Methods A total of 100 patients collected from New Medical Hospital, Kota (Rajasthan), India. Weight, height, waist circumference (WC) and hip circumference were measured. Waist–hip ratio (WHR) was calculated. Samples were analysed on autoanalyser.
Results and Discussion In the present study, we found that the WHR is not significantly associated with lipid parameters in male patients except for TG and high-density lipoprotein (HDL). Non-significant correlation was obtained in female patients. Statistically negative significant correlation was found in serum for HDL between fifth and sixth decade of life. No significant correlation was found in any other age groups.
Summary and Conclusion WC and WHR are the important indicators of obesity and can be used to predict incidence of obesity in Indian population. Further broad study is advised.
Keywords lipid profile, waist–hip ratio, diabetes mellitus
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.
Original article
Wen-Shan Huang1,Yi-Fang Li1,Huan Chen1,Ting-Mei Wang1,Hiroshi Kurihara1,2, Rong-Rong He1,2*
1Anti-Stress and Health Research center,College of Pharmacy, Jinan University, Guangzhou, China
2Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
Address reprint requests to
*Rong-Rong He,
Anti-Stress and Health Research center, College of Pharmacy,Jinan University, Guangzhou, China
Article citation: Huang WS, Li YF, Chen H, Wang TM, Kurihara H, He RR. The ameliorative effects of CE (a chicken extract) on learning and memory function of restraint-stressed mice. J Pharm Biomed Sci 2016;06(03):259–263. Available at www.jpbms.info
ABSTRACT
In this study, we studied the effects of Chicken Essence (CE) on learning and memory function of restraint-stressed mice. Male Kunming mice of 7-week-old were randomly divided into five groups as follows: normal control, restraint stress control, low dosage of CE (12 ml/kg/d, CE-L) and high dosage of CE (24 ml/kg/d, CE-H). The normal control group and restrain stress control group received water only. On the 14th day of administration,all mice were conducted to step through training, and physically restrained
in a 50 ml restrained tube with holes for 18 h except for normal control mice. All mice were conducted to step through testing, 1 day after restraint stress. All animals were anesthetized, their brains and blood were obtained. We determined the neuron protective transmitters, dopamine hydrochloride and norepinephrine level in brain and plasma via ESA–HPLC. The results showed that the administration of CE could improve the impaired function of learning and memory. Furthermore, it also recovered the changed levels of neurotransmitters in brain or plasma in restraint-stressed mice.
Keywords learning and memory; restraint stress; stress hormone
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Sources of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the
official policy or position of the Department of Defense.