DocumentsDate added
Original research article:-
*Jothieswari. D1, 2, Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4, Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in pharmaceutical formulation using RP - C18 column. The mobile phase (acetonitrile: methanol: 50 mM phosphate buffer adjusted to pH 3 with orthophosphoric acid) was pumped at a flow rate of 1.0 mL min-1 in the ratio of 20: 50: 30% v/ v and the eluents were monitored at 239 nm. Linearity was obtained in the concentration range of 0.5 – 5 g mL-1 for amlodipine besylate, 4 - 40 g mL-1 for valsartan and 1 – 10 g mL-1 for hydrochlorothiazide. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method can be applied for determining amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in pharmaceutical dosage form.
Keywords: Amlodipine besylate, valsartan, hydrochlorothiazide, RP - HPLC.
Original research article:-
*Damerakonda Kumaraswamy1,Vanga mallareddy2
1.Department of Pharmaceutical Chemistry,Vaagdevi College of Pharmacy,Hanamkonda,Warangal, Andhrapradesh,India.
2.Department of Medicinal Chemistry, Devis lab,Research and Development unit,Hyderabad, Andhrapradesh. India.
Abstract:-The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded asingle product in each case.The mannich bases obtained have been characterized as the corresponding 2-S-substituted amino methyl thio-3-aryl 4(3H) quinazolinone(VI) on the basis of analytical spectral data.These S-Substituted compounds have been screened for their Anti- bacterial,Anti -fungal,Anti- inflammatory and Analgesic activities.
Original research article:-
*Damerakonda Kumaraswamy1, Vanga malla Reddy1 Department of Pharmaceutical Chemistry ,Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India.
Absract :The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded a single product in each case. The mannich bases obtained have been characterized as the corresponding 1-(N-Substituted amino methyl )-3-aryl-3,4-dihydro-4-oxoquinazolin-2-thione on the basis of analytical spectral data. These N-Substituted compounds have been screened for their Anti bacterial, Anti-fungal, Anti inflammatory and Analgesic activities.
Research article:-
Dhatri Devi. N1, *Siddalingeshwara K.Gurubasappa1, Sunil Dutt P L N S N2, Vishwanatha T3, and Ramesha I3, Jayaramu M4, Dwarakanath V4, Naveen M5 , Sumanth B.K6.
1.Department of Microbiology and Biochemistry Padmashree Institute of Information Sciences, Nagarabhavi, Circle.Bangalore-72, India.
2.Research and Development Centre Bharathiar University, Coimbatore, India. 3.Department of Microbiology and Zoology, Maharani Science college for Women, Bangalore-01.India.
4.Department of Microbiology and Biotechnology, Tumkur University, Tumkur, India. 5.Department of Microbiology, Govt Science College, Bangalore, India.
6.Department of Biotechnology, Kuvempu University. Shankaraghatta, India.
Abstract:- Twenty one Aspergillus wentii isolates were isolated from the soil samples were screened for L-glutaminase synthesis by plate assay method. Among the isolates the potential Aspergillus wentii SD4 were used for the synthesis in elevated level of L-glutaminase by optimizing the fermentation parameters like pH, temperature and inoculums size. The optimized pH will be 5.5 and it showed 1.71 IU. Temperature and inoculums sizes were also optimized as 350C and 1.0 ml (1x107). At this level these parameters shows 2.22IU and 2.73IU in elevated levels.
Key words: Aspergillus wentii, L-glutaminase, Fermentation kinetics, tumour inhibitor.
Review article:-
Navin K. Dahiya1, *Rekha Rao1, Sanju Nanda2
1.Department of Pharmaceutics, M.M. University, Mullana, Ambala, Haryana, India-133203. 2.Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, India -124001.
Abstract:- Started in 1970’s by cosmetic scientists, the research investigations in the field of niosomal vesicular systems are increasing exponentially with growing interest in these fields. The stream of these vesicles is still in its infancy, but the explosion of interest in niosomes as inherently active therapeutic agents, as vectors for targeted delivery of drugs, peptides and hormones and able to promote oral and transdermal drug delivery makes it timely to review current knowledge regarding various aspects of niosomes. Niosomes are non-ionic surfactant based vesicles formed from the self assembly of non-ionic amphiphiles in aqueous media resulting in closed bilayer structure which can entrap both lipophilic and hydrophilic drugs. The biocompatible and biodegradable nature makes them less toxic as compared to other vesicular systems. Lower cost of niosomes is attributed to greater availability of non-ionic surfactants. These properties make them versatile carriers and interesting candidate for study. The emphasis of this review is on potential of niosomes in drug delivery applications. The composition of niosomes and especially non-ionic surfactants are discussed in detail. Preparation methods are outlined separately for these vesicular systems. In addition, this article concentrates on the success in developing niosomes as potential carriers, in this millennium.
Key words: Non-ionic surfactants, Niosomes, Liposome, Drug delivery.