DocumentsDate added
Original research article:-
*Harika Chanda1 Palash Das1, Rahul Chakraborty 2, Arpita Ghosh 3
*1,2.Department of Pharmaceutics, MLR Institute of Pharmacy, Hyderabad, India. 1.Department of Pharmaceutics, Sri Krupa college of Pharmacy, Siddipet, India. 3.Department of Pharmaceutics, Vikas college of Pharmacy, Jangaon, India.
Abstract Aims:-The purpose of research involves to prepare the liposomes of anti fungal drug, fluconazole which were encapsulated in the form of liposomes for topical application and to improve the therapeutic response and reduce the possible adverse symptoms. Here liposomes of Fluconazole were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized for size, shape, entrapment efficiency, in-vitro drug release (by franz diffusion cell) and physical stability. The studies demonstrated successful preparation of Fluconazole liposomes and effect of soya lecithin: cholesterol weight ratio on entrapment efficiency and on drug release.
Keywords: Antifungal, liposomes, fluconazole, soya lecithin, cholesterol.
Review article:-
*Jain Hitesh 1, Gediya Shweta K.1, Thakkar Dadhichi K.1, Mansuri Nasimabanu Y.1, Ashar Komal M.2, Pasha T.Y.3
1.Sigma Institute of Pharmacy, Baroda, Gujarat, India.
2.Baroda medical College, Baroda, Gujarat, India.
3.Pioneer Pharmacy College, Baroda, Gujarat, India.
Abstract:-Crimean Congo hemorrhagic fever (CCHF) has the most extensive geographic distribution of the medically significant tick-borne viruses. Its causative agent is a negative-sense, single-stranded RNA virus belonging to the family Bunyaviridae, genus Nairovirus. The virus can be transmitted mainly through direct contact with blood or tissues from infected livestock or through bites of Hyalomma ticks. CCHF is a public health problem in many regions of the world, including Africa, Middle East, southern and Eastern Europe, and Western Asia. Crimean-Congo hemorrhagic fever (CCHF) virus causes a hemorrhagic and toxic syndrome disease in humans and high mortality rates of up to 50%. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase are raised, and bleeding markers are prolonged. Infection of the endothelium has a major pathogenic role. Besides direct infection of the endothelium, indirect damage by viral factors or virus-mediated host-derived soluble factors that cause endothelial activations and dysfunction are thought to occur. In diagnosis, enzyme-linked immunoassay and real-time reverse transcriptase polymerase chain reaction are used.
Key Words: Crimean haemorrhagic fever (CCHF), Nairovirus, Ribavirin.
Original research article:-
Tanuja Shailesh1, Dinesh Acharya U2, * Shailesh K R3
1,2.Dept. of CSE, MIT, Manipal University, Karnataka ,India.
3.Dept. of E & E, MIT, Manipal University, Karnataka , India.
Abstract:-Data mining has a wide use in the healthcare domain in areas such as diagnoses and patient management. One of the main concerns in the healthcare area is the measurement of flow of patients through hospitals and other health care facilities. For instance if the inpatient length of stay (LOS) can be predicted efficiently, the planning and management of hospital resources can be greatly enhanced. Hospital LOS of inpatients is frequently used as a proxy for measuring the consumption of hospital resources and therefore it is essential to develop accurate models for the prediction of inpatients LOS. In this paper we apply text mining techniques to pre-process the text data of electronic discharge summaries available in HTML format and apply traditional data mining techniques such as k-means clustering to analyze the textual information for classifying discharge summaries based on disease and patient’s length of stay in the hospital.
Keywords: Text mining, Discharge Summary, Regular Expression, feature extraction, Pattern recognition, length of stay, K-Means.
Review article:-
*Umashankar Lakshmanadoss1, Monika Moni1, Priya Chinnachamy 2 1.Division of Hospital Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD1, USA.
2.All India Institute of Medical Sciences, New Delhi, India.
Abstract:-Blood transfusion is one of the common interventions done in the hospital setting on a daily basis. Complications of blood transfusions are becoming rare, thanks to the advanced technology. However, just because of the total number of transfusions, medical and paramedical persons may encounter these situations more often than thought. Complications related to blood transfusion may be divided in to acute and delayed transfusion reactions based on the time of presentations. Acute reaction ranges from allergic reactions and febrile nonhemolytic reactions which are benign to febrile hemolytic reactions which could be life threatening. In addition to these febrile reaction, development of hypoxia after transfusion is always concerning as this could be a manifestation of circulatory volume overload or Transfusion Related Lung Injury (TRALI). Differentiating TRALI from circulatory volume overload is very important as diuretics are indicated in circulatory overload and they are not useful in TRALI. Transfusion related infections are rare nowadays thanks to the advanced technology. Most common cause of blood transfusion errors are due to human errors. Transfusion is a multistep procedure and needs a constant vigil at various levels to prevent these complications. A unique barcode on each patient’s wristband is used to identify the patient’s cross-match blood samples and each unit of blood prepared for that patient. This program have been tested and implemented successfully in various institutions including the author's institution (UL). Here, we are presenting a patient who developed TRALI following blood transfusion. In this article, we also reviewed the complications of blood transfusion, ways to prevent them and their management.
Original research article:-
Rattan Deep Singh1, Juhi Mishra1, Anoop Kumar Dobriyal 2, *Aradhana1
1.Dept. of Biotechnology, S. Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, India.
2.Dept. of Zoology and Biotechnology, Hemwati Nandan Bahuguna Garhwal University, Pauri Campus, Pauri-Garhwal, India.
Abstract:- The present study is based on analysis of various physio-chemical properties of crude extract of lectins from selected Phaseolus vulgaris landraces. The haemagglutination and sugar inhibiting properties differ among the landraces. Sample from Dhanpoo and Darchula show maximum haemagglutinating activity (16HU). The minimum inhibitory concentration of sugar among cultivars was found in the range of 25-50 mM. The haemagglutinating activity of lectins was found to be stable upto temperature of 700C, above which there was no haemagglutinating activity. Similarly the lectin activity was found to be stable at pH range of 7-8, which means haemagglutination activity is negligible in too acidic and basic medium. The crude extract of lectins was subjected for partial purification through ammonium sulphate precipitation and SDS-PAGE analysis. The molecular weight of lectin was found to be 34kd, which is similar to commercially prepared Phytohaemagglutinin used as a standard.
Keywords:-Phytohaemagglutinin, Sugar inhibition, Haemagglutination titer.