DocumentsDate added
Review article:-
*VijayKumar Chauhan1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, Lokendra Pal Singh1, Khushbu Shah1, Kuldipsinh Pagi1.
1.Department of Pharmaceutics, Parul Institute of Pharmacy, Limda, Vadodara, Gujarat-391760, India.
Abstract:-Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (MDTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self administration without water or chewing. This novel type of delivery system offers convenience for treatment-resistant population who have difficulty in swallowing unit oral dosage form, namely Tablets and Capsules. These formulations are particularly beneficial to pediatric and geriatric patients. It is estimated that 50 % of the population is affected by dysphagia which results in high incidence of non-compliance and ineffective therapy. The aim of this article is to review the ideal properties, significance, characteristics, limitation, choice of drug candidates, challenges in formulation, approaches for preparation of MDTs, Patented technologies on MDTs, Suitable drug candidates for MDTs, Marketed product of MDTs, and Evaluation tests of MDTs.
Key words: Fast disintegrating, Mouth Dissolving Tablet, Dysphagia.
Review article:- 1Kinja Kuldeep*, 1Patel Hiten, 1Gupta Nakul
1.NIMS Institute of Pharmacy, Shobha Nagar, Jaipur-303121 Rajasthan, India.
Abstract Genetic disorders are either hereditary disorders or a result of mutations. Some disorders may confer an advantage, at least in certain environments. A genetic disorder is an illness caused by abnormalities in genes or chromosomes. Most disorders are quite rare and affect one person in every several thousands or millions. Some types of recessive gene disorders confer an advantage in the heterozygous state in certain environments. Genetic disorders rarely have effective treatments, though gene therapy is being tested as a possible treatment for some genetic diseases. There are mainly two types of genetic disorders are there. These are Single gene disorder and multifactorial and polygenic (complex) disorders. Single gene disorders are again of different types- Autosomal dominant, Autosomal recessive, X-linked dominant, X-linked recessive, Y-linked and Mitochondrial. Currently around 4,000 genetic disorders are known, with more being discovered. Most disorders are quite rare and affect one person in every several thousands or millions. In this article we only discussed about main four hereditary disorders which are having a high mortality and occurrence rate. These are Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Key Words: Hereditary, Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Original research article:-
*Damerakonda Kumaraswamy1,Vanga mallareddy2
1.Department of Pharmaceutical Chemistry,Vaagdevi College of Pharmacy,Hanamkonda,Warangal, Andhrapradesh,India.
2.Department of Medicinal Chemistry, Devis lab,Research and Development unit,Hyderabad, Andhrapradesh. India.
Abstract:-The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded asingle product in each case.The mannich bases obtained have been characterized as the corresponding 2-S-substituted amino methyl thio-3-aryl 4(3H) quinazolinone(VI) on the basis of analytical spectral data.These S-Substituted compounds have been screened for their Anti- bacterial,Anti -fungal,Anti- inflammatory and Analgesic activities.
Original research article:-
* Mrs. G. Indira1,Prof G.Raghuramulu1, Prof.S.Ramreddy2, Prof.Kondal Rao3.
1* Asst Prof .in microbiology, Dept. of Microbiology. Pingle govt Degree and PG college,Warangal ,Andhra Pradesh, India.
1.Dept. of Zoology, Kakatiya university, Warangal, Andhra Pradesh,India.
2.Dept. of Microbiology, Kakatiya university, Warangal, Andhra Pradesh, India.
3.Dept. of Microbiology, Kakatiya Medical College, Warangal, Andhra Pradesh, India.
Abstract:-Trichophyton is the commonest dermatophyte which is geophilic, zoophilic and anthrophilic in nature. The genus Trichophyton includes 24 species; some of these are saprophytes. The most common human pathogenic species of Tricophyton genus are T.mentagrophytes 1 and T.rubrum2. These causes tinea corporis, tinea cruris, tinea pedis, tinea capitis, tinea unguium by infecting skin, hair and nail respectively. The two species can be differentiated on the basis of biochemical tests like urease test 3 invitro hair perforation test4 . These are also identified on the culture characters like macro and micro conidia. These rarely produce macro conidia which may be clavate or cigar shaped or elongated, pencil shaped. Microconidia are abundant and may be globose or pyri form and are born singly along the sides of hyphae or in grape like clusters. Key Words: Trichophyton mentagrophytes, T.rubrum, Sabouraud agar medium, urease test, hair perforation test, microconidia .
Review article:-
*Preeti singh1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal1 Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:-Liver toxicity is caused by different compounds in which oxidants or free radicals plays a major role. They are very hazardous to our body by damaging the proteins, DNA, RNA and lipids, due to of this virtue. They can cause very severe diseases like Neurodegeneration, Hepatotoxicity, Aging, Cancer, Cardiovascular disease, Immune system decline and Cataract. To avoid these problems, antioxidants used, which act as free radical scavengers. Antioxidants are present naturally; endogenously (superoxide dismutase, H2O2-removing enzymes and metal binding proteins) yet they are not sufficient to prevent damaging at the oxidative stage, but dietary antioxidants (vitamin A, E, C, carotenoids and plant phenol like flavonoids) as a special nutrient. Lipid peroxidation is the major cause of hepatotoxicity caused by oxidative stress. The primary induction of hepatotoxicity is inducing level of liver enzymes as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Gamma-glutamyltransferase (GGT). Most of the mechanism of antioxidants is to decrease the elevated level of the enzymes in serum via different mechanism and in case of liver toxicity eventually to stops the lipid peroxidation. In this scenario extract of plants like Silymarin; Terminalia catappa L; Byrsocarpus coccineus and more species of plants, and their secondary metabolites are proved to be impressive useful as hepatoprotectives.
Key Words: Antioxidants; Hepatoprotectives; Free radicals; ROS; Lipid peroxidation; Oxidative stress.