DocumentsDate added
Original research article:-
Tanuja Shailesh1, Dinesh Acharya U2, * Shailesh K R3
1,2.Dept. of CSE, MIT, Manipal University, Karnataka ,India.
3.Dept. of E & E, MIT, Manipal University, Karnataka , India.
Abstract:-Data mining has a wide use in the healthcare domain in areas such as diagnoses and patient management. One of the main concerns in the healthcare area is the measurement of flow of patients through hospitals and other health care facilities. For instance if the inpatient length of stay (LOS) can be predicted efficiently, the planning and management of hospital resources can be greatly enhanced. Hospital LOS of inpatients is frequently used as a proxy for measuring the consumption of hospital resources and therefore it is essential to develop accurate models for the prediction of inpatients LOS. In this paper we apply text mining techniques to pre-process the text data of electronic discharge summaries available in HTML format and apply traditional data mining techniques such as k-means clustering to analyze the textual information for classifying discharge summaries based on disease and patient’s length of stay in the hospital.
Keywords: Text mining, Discharge Summary, Regular Expression, feature extraction, Pattern recognition, length of stay, K-Means.
Original research article:-
Rattan Deep Singh1, Juhi Mishra1, Anoop Kumar Dobriyal 2, *Aradhana1
1.Dept. of Biotechnology, S. Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, India.
2.Dept. of Zoology and Biotechnology, Hemwati Nandan Bahuguna Garhwal University, Pauri Campus, Pauri-Garhwal, India.
Abstract:- The present study is based on analysis of various physio-chemical properties of crude extract of lectins from selected Phaseolus vulgaris landraces. The haemagglutination and sugar inhibiting properties differ among the landraces. Sample from Dhanpoo and Darchula show maximum haemagglutinating activity (16HU). The minimum inhibitory concentration of sugar among cultivars was found in the range of 25-50 mM. The haemagglutinating activity of lectins was found to be stable upto temperature of 700C, above which there was no haemagglutinating activity. Similarly the lectin activity was found to be stable at pH range of 7-8, which means haemagglutination activity is negligible in too acidic and basic medium. The crude extract of lectins was subjected for partial purification through ammonium sulphate precipitation and SDS-PAGE analysis. The molecular weight of lectin was found to be 34kd, which is similar to commercially prepared Phytohaemagglutinin used as a standard.
Keywords:-Phytohaemagglutinin, Sugar inhibition, Haemagglutination titer.
Review article:- 1Kinja Kuldeep*, 1Patel Hiten, 1Gupta Nakul
1.NIMS Institute of Pharmacy, Shobha Nagar, Jaipur-303121 Rajasthan, India.
Abstract Genetic disorders are either hereditary disorders or a result of mutations. Some disorders may confer an advantage, at least in certain environments. A genetic disorder is an illness caused by abnormalities in genes or chromosomes. Most disorders are quite rare and affect one person in every several thousands or millions. Some types of recessive gene disorders confer an advantage in the heterozygous state in certain environments. Genetic disorders rarely have effective treatments, though gene therapy is being tested as a possible treatment for some genetic diseases. There are mainly two types of genetic disorders are there. These are Single gene disorder and multifactorial and polygenic (complex) disorders. Single gene disorders are again of different types- Autosomal dominant, Autosomal recessive, X-linked dominant, X-linked recessive, Y-linked and Mitochondrial. Currently around 4,000 genetic disorders are known, with more being discovered. Most disorders are quite rare and affect one person in every several thousands or millions. In this article we only discussed about main four hereditary disorders which are having a high mortality and occurrence rate. These are Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Key Words: Hereditary, Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Review article:-
*Preeti singh1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal1 Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:-Liver toxicity is caused by different compounds in which oxidants or free radicals plays a major role. They are very hazardous to our body by damaging the proteins, DNA, RNA and lipids, due to of this virtue. They can cause very severe diseases like Neurodegeneration, Hepatotoxicity, Aging, Cancer, Cardiovascular disease, Immune system decline and Cataract. To avoid these problems, antioxidants used, which act as free radical scavengers. Antioxidants are present naturally; endogenously (superoxide dismutase, H2O2-removing enzymes and metal binding proteins) yet they are not sufficient to prevent damaging at the oxidative stage, but dietary antioxidants (vitamin A, E, C, carotenoids and plant phenol like flavonoids) as a special nutrient. Lipid peroxidation is the major cause of hepatotoxicity caused by oxidative stress. The primary induction of hepatotoxicity is inducing level of liver enzymes as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Gamma-glutamyltransferase (GGT). Most of the mechanism of antioxidants is to decrease the elevated level of the enzymes in serum via different mechanism and in case of liver toxicity eventually to stops the lipid peroxidation. In this scenario extract of plants like Silymarin; Terminalia catappa L; Byrsocarpus coccineus and more species of plants, and their secondary metabolites are proved to be impressive useful as hepatoprotectives.
Key Words: Antioxidants; Hepatoprotectives; Free radicals; ROS; Lipid peroxidation; Oxidative stress.
Original research article:-
Monika Gupta* Department of Chemistry, University of Jammu, Jammu-180 006, India.
Abstract:-A simple and fast procedure is developed for the one-pot synthesis of novel 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines from 5-aryl-3,4-diamino-1,2,4-triazoles and acetophenone or substituted acetophenones in the presence of catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium as well as homogenizer using microwave irradiation as well as by stirring at 800C in a pre-heated oil-bath. Comparative method is simple, fast and economic and gives moderate to good yields of products and are in a state of high purity. Some of these compounds are evaluated for antifungal activity.
Keywords:-Acetophenones, triazoles, triazepines, triazolo-triazepines, N,N-dimethylformamide, p-TsOH, microwave activation.