DocumentsDate added
Review article:-
*Lokendra Pal Singh1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, VijayKumar Chauhan1, Viralkumar Rana1 , Kamini S. Vasava1.
1.Department of Pharmaceutics, Parul institute of Pharmacy, Limda, Vadodara, Gujarat-391760,India.
Abstract:-In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract which includes floating drug dosage systems (FDDS) , effervescent and non effervescent system, swelling or expanding systems, mucoadhesive systems magnetic systems, modified-shape systems, high density system and other delayed gastric emptying devices. Among these systems, FDDS have been most commonly used. Effervescent FDDS are the most advantageous approach to gastric retention effervescent agent produce CO2 When come to contact with G.I fluid and support to float dosage form.
Keywords: Gastro retentive systems; Floating systems; buoyant delivery Systems; Swelling system.
Original research article:-
*Jothieswari. D1, 2, Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4, Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in pharmaceutical formulation using RP - C18 column. The mobile phase (acetonitrile: methanol: 50 mM phosphate buffer adjusted to pH 3 with orthophosphoric acid) was pumped at a flow rate of 1.0 mL min-1 in the ratio of 20: 50: 30% v/ v and the eluents were monitored at 239 nm. Linearity was obtained in the concentration range of 0.5 – 5 g mL-1 for amlodipine besylate, 4 - 40 g mL-1 for valsartan and 1 – 10 g mL-1 for hydrochlorothiazide. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method can be applied for determining amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in pharmaceutical dosage form.
Keywords: Amlodipine besylate, valsartan, hydrochlorothiazide, RP - HPLC.
Original research article:-
*Jothieswari. D1,2 , Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4,Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water. This method involves the formation and solving of simultaneous equations at 239 nm, 250 nm and 272 nm, as absorbance maxima of amlodipine besylate, valsartan and hydrochlorothiazide, respectively. Beer’s law obeyed the concentration range of 1 – 32 mcg/ mL, 4 – 40 mcg/ mL and 2 – 20 mcg/ mL for amlodipine besylate, valsartan and hydrochlorothiazide, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the simultaneous estimation of these three drugs in bulk and in combined tablet dosage form.
Keywords:- Amlodipine Besylate, Valsartan, Hydrochlorothiazide, Simultaneous equation method, Method validation.
Original research article:-
*Harika Chanda1 Palash Das1, Rahul Chakraborty 2, Arpita Ghosh 3
*1,2.Department of Pharmaceutics, MLR Institute of Pharmacy, Hyderabad, India. 1.Department of Pharmaceutics, Sri Krupa college of Pharmacy, Siddipet, India. 3.Department of Pharmaceutics, Vikas college of Pharmacy, Jangaon, India.
Abstract Aims:-The purpose of research involves to prepare the liposomes of anti fungal drug, fluconazole which were encapsulated in the form of liposomes for topical application and to improve the therapeutic response and reduce the possible adverse symptoms. Here liposomes of Fluconazole were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized for size, shape, entrapment efficiency, in-vitro drug release (by franz diffusion cell) and physical stability. The studies demonstrated successful preparation of Fluconazole liposomes and effect of soya lecithin: cholesterol weight ratio on entrapment efficiency and on drug release.
Keywords: Antifungal, liposomes, fluconazole, soya lecithin, cholesterol.
Review article:-
Navin K. Dahiya1, *Rekha Rao1, Sanju Nanda2
1.Department of Pharmaceutics, M.M. University, Mullana, Ambala, Haryana, India-133203. 2.Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, India -124001.
Abstract:- Started in 1970’s by cosmetic scientists, the research investigations in the field of niosomal vesicular systems are increasing exponentially with growing interest in these fields. The stream of these vesicles is still in its infancy, but the explosion of interest in niosomes as inherently active therapeutic agents, as vectors for targeted delivery of drugs, peptides and hormones and able to promote oral and transdermal drug delivery makes it timely to review current knowledge regarding various aspects of niosomes. Niosomes are non-ionic surfactant based vesicles formed from the self assembly of non-ionic amphiphiles in aqueous media resulting in closed bilayer structure which can entrap both lipophilic and hydrophilic drugs. The biocompatible and biodegradable nature makes them less toxic as compared to other vesicular systems. Lower cost of niosomes is attributed to greater availability of non-ionic surfactants. These properties make them versatile carriers and interesting candidate for study. The emphasis of this review is on potential of niosomes in drug delivery applications. The composition of niosomes and especially non-ionic surfactants are discussed in detail. Preparation methods are outlined separately for these vesicular systems. In addition, this article concentrates on the success in developing niosomes as potential carriers, in this millennium.
Key words: Non-ionic surfactants, Niosomes, Liposome, Drug delivery.