DocumentsDate added
Original Research article:-
*S. Emmanuel Joshua Jebasingh1, S. Rosemary1, S. Elaiyaraja1, K. Sivaraman1, M. Lakshmikandan1, A. Murugan2, P. Raja2.
1.Department of Biotechnology, Sri Paramakalyani Center for Excellence in Environmental Science, Manonmaniam Sundaranar University, Tirunelveli, Tamil nadu, India- 627412. 2.Suganthi Devadason Marine Research Institute, Tuticorin, Tamil nadu, India- 628001.
Abstract:-The seaweed species (Enteromorpha compressa, Enteromorpha intestinalis, Caulerpa scalpelliformis, Caulerpa racemosa, Chaetomorpha linum, Gracilaria foliifera, Hypnea valentiae) were collected from Gulf of Mannar, Tuticorin coast and the samples were air dried: Six different solvents (hexane, diethyl ether, chloroform, ethyl acetate, ethanol, acetone and methanol) were used for the extraction of seaweeds. The antibacterial activity of seaweed extracts was checked against six human pathogens. The acetone extract of Caulerpa scalpelliformis showed broad spectrum antibacterial activity when compared to other seaweed extracts. Acetone extract of Caulerpa scalpelliformis was further fractionated and purified using chromatographic separation techniques using bioassay guided fractionation and the active fraction purity was checked by HPLC.
Keywords:-Seaweeds, Antibacterial activity, Gulf of Mannar, Caulerpa scalpelliformis, Natural product.
Review article:- 1Kinja Kuldeep*, 1Patel Hiten, 1Gupta Nakul
1.NIMS Institute of Pharmacy, Shobha Nagar, Jaipur-303121 Rajasthan, India.
Abstract Genetic disorders are either hereditary disorders or a result of mutations. Some disorders may confer an advantage, at least in certain environments. A genetic disorder is an illness caused by abnormalities in genes or chromosomes. Most disorders are quite rare and affect one person in every several thousands or millions. Some types of recessive gene disorders confer an advantage in the heterozygous state in certain environments. Genetic disorders rarely have effective treatments, though gene therapy is being tested as a possible treatment for some genetic diseases. There are mainly two types of genetic disorders are there. These are Single gene disorder and multifactorial and polygenic (complex) disorders. Single gene disorders are again of different types- Autosomal dominant, Autosomal recessive, X-linked dominant, X-linked recessive, Y-linked and Mitochondrial. Currently around 4,000 genetic disorders are known, with more being discovered. Most disorders are quite rare and affect one person in every several thousands or millions. In this article we only discussed about main four hereditary disorders which are having a high mortality and occurrence rate. These are Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Key Words: Hereditary, Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Original research article:-
Monika Gupta* Department of Chemistry, University of Jammu, Jammu-180 006, India.
Abstract:-A simple and fast procedure is developed for the one-pot synthesis of novel 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines from 5-aryl-3,4-diamino-1,2,4-triazoles and acetophenone or substituted acetophenones in the presence of catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium as well as homogenizer using microwave irradiation as well as by stirring at 800C in a pre-heated oil-bath. Comparative method is simple, fast and economic and gives moderate to good yields of products and are in a state of high purity. Some of these compounds are evaluated for antifungal activity.
Keywords:-Acetophenones, triazoles, triazepines, triazolo-triazepines, N,N-dimethylformamide, p-TsOH, microwave activation.
Original research article:-
*Jothieswari. D1,2 , Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4,Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water. This method involves the formation and solving of simultaneous equations at 239 nm, 250 nm and 272 nm, as absorbance maxima of amlodipine besylate, valsartan and hydrochlorothiazide, respectively. Beer’s law obeyed the concentration range of 1 – 32 mcg/ mL, 4 – 40 mcg/ mL and 2 – 20 mcg/ mL for amlodipine besylate, valsartan and hydrochlorothiazide, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the simultaneous estimation of these three drugs in bulk and in combined tablet dosage form.
Keywords:- Amlodipine Besylate, Valsartan, Hydrochlorothiazide, Simultaneous equation method, Method validation.
Review article:-
*Baiju Gopalan Nair 1 K Amarendhar Reddy 1, Naga Lakshmi Reddy 1, Upendranath Reddy1
1Department of Conservative Dentistry & Endodontics,G Pulla Reddy Dental College & Hospital, Kurnool ,Andhrapradesh, India.
Abstract:-The success in endodontics depends on complete eradication of microbes from the root canal system which effectively prevents re infection. the introduction of rotary instruments help the canal preparation more effective especially in the apical third, there by helping the effectiveness of the irrigants to penetrate till the root apex. This helped to control the microbial level at the apical third of the root canals. The irrigants which use to be delivered using the traditional methods like syringes and needles of different size and tip design prove d to be ineffective. In the recent years, chemical composition of irrigants and mechanical devices which helps in irrigation has been improved leaps and bounds. This article summarizes the recent developments for the safe and effective irrigation which ultimately helps to minimize the bacterial levels resulting in successive endodontic therapy.
Key words:-Root canal Irrigants, Root canal disinfection, Smear layer, Endovac- irrigating system, PUI, Lasers, Quantec-e irrigation system, Bioglasses, Ozone therapy.