DocumentsDate added
Research article:-
* M.S.S. Devi1, B.Sampath Kumar2.
1Dept of pharmacology, Chennai.India
2Professor, Dept of Pharmacology,India.
Abstract: In excision wound model Siddha kalimbu produced a significant decrease (P<0.001) in period of epithelization when compared to control. Treatment with Control skin Cream also produced significant (P<0.001) reduction in the period of epithelization. The treatment also showed significant decrease in wound contraction (50%) as compared to control. In the incision wound model, both Siddha kalimbu and Control skin Cream produced a significant increase (P<0.001) in the breaking strength of the wound when compared with the control group. Histopathology of granuloma tissue obtained from the Siddha kalimbu and Control skin Cream treated group showed a significant increase in collagen deposition with few macrophages and more fibroblasts.
Keywords: Excision wound, Control skin Cream, Histological studies, Incision wound, Siddha kalimbu.
Review article:-
*Lokendra Pal Singh1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, VijayKumar Chauhan1, Viralkumar Rana1 , Kamini S. Vasava1.
1.Department of Pharmaceutics, Parul institute of Pharmacy, Limda, Vadodara, Gujarat-391760,India.
Abstract:-In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract which includes floating drug dosage systems (FDDS) , effervescent and non effervescent system, swelling or expanding systems, mucoadhesive systems magnetic systems, modified-shape systems, high density system and other delayed gastric emptying devices. Among these systems, FDDS have been most commonly used. Effervescent FDDS are the most advantageous approach to gastric retention effervescent agent produce CO2 When come to contact with G.I fluid and support to float dosage form.
Keywords: Gastro retentive systems; Floating systems; buoyant delivery Systems; Swelling system.
Original research article:-
*Jothieswari. D1, 2, Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4, Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in pharmaceutical formulation using RP - C18 column. The mobile phase (acetonitrile: methanol: 50 mM phosphate buffer adjusted to pH 3 with orthophosphoric acid) was pumped at a flow rate of 1.0 mL min-1 in the ratio of 20: 50: 30% v/ v and the eluents were monitored at 239 nm. Linearity was obtained in the concentration range of 0.5 – 5 g mL-1 for amlodipine besylate, 4 - 40 g mL-1 for valsartan and 1 – 10 g mL-1 for hydrochlorothiazide. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method can be applied for determining amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in pharmaceutical dosage form.
Keywords: Amlodipine besylate, valsartan, hydrochlorothiazide, RP - HPLC.
Original research article:-
*Jothieswari. D1,2 , Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4,Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water. This method involves the formation and solving of simultaneous equations at 239 nm, 250 nm and 272 nm, as absorbance maxima of amlodipine besylate, valsartan and hydrochlorothiazide, respectively. Beer’s law obeyed the concentration range of 1 – 32 mcg/ mL, 4 – 40 mcg/ mL and 2 – 20 mcg/ mL for amlodipine besylate, valsartan and hydrochlorothiazide, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the simultaneous estimation of these three drugs in bulk and in combined tablet dosage form.
Keywords:- Amlodipine Besylate, Valsartan, Hydrochlorothiazide, Simultaneous equation method, Method validation.
Original Research article:-
*S. Emmanuel Joshua Jebasingh1, S. Rosemary1, S. Elaiyaraja1, K. Sivaraman1, M. Lakshmikandan1, A. Murugan2, P. Raja2.
1.Department of Biotechnology, Sri Paramakalyani Center for Excellence in Environmental Science, Manonmaniam Sundaranar University, Tirunelveli, Tamil nadu, India- 627412. 2.Suganthi Devadason Marine Research Institute, Tuticorin, Tamil nadu, India- 628001.
Abstract:-The seaweed species (Enteromorpha compressa, Enteromorpha intestinalis, Caulerpa scalpelliformis, Caulerpa racemosa, Chaetomorpha linum, Gracilaria foliifera, Hypnea valentiae) were collected from Gulf of Mannar, Tuticorin coast and the samples were air dried: Six different solvents (hexane, diethyl ether, chloroform, ethyl acetate, ethanol, acetone and methanol) were used for the extraction of seaweeds. The antibacterial activity of seaweed extracts was checked against six human pathogens. The acetone extract of Caulerpa scalpelliformis showed broad spectrum antibacterial activity when compared to other seaweed extracts. Acetone extract of Caulerpa scalpelliformis was further fractionated and purified using chromatographic separation techniques using bioassay guided fractionation and the active fraction purity was checked by HPLC.
Keywords:-Seaweeds, Antibacterial activity, Gulf of Mannar, Caulerpa scalpelliformis, Natural product.