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Original research article:-
Monika Gupta* Department of Chemistry, University of Jammu, Jammu-180 006, India.
Abstract:-A simple and fast procedure is developed for the one-pot synthesis of novel 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines from 5-aryl-3,4-diamino-1,2,4-triazoles and acetophenone or substituted acetophenones in the presence of catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium as well as homogenizer using microwave irradiation as well as by stirring at 800C in a pre-heated oil-bath. Comparative method is simple, fast and economic and gives moderate to good yields of products and are in a state of high purity. Some of these compounds are evaluated for antifungal activity.
Keywords:-Acetophenones, triazoles, triazepines, triazolo-triazepines, N,N-dimethylformamide, p-TsOH, microwave activation.
Original research article:-
*Damerakonda Kumaraswamy1, Vanga malla Reddy1 Department of Pharmaceutical Chemistry ,Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India.
Absract :The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded a single product in each case. The mannich bases obtained have been characterized as the corresponding 1-(N-Substituted amino methyl )-3-aryl-3,4-dihydro-4-oxoquinazolin-2-thione on the basis of analytical spectral data. These N-Substituted compounds have been screened for their Anti bacterial, Anti-fungal, Anti inflammatory and Analgesic activities.
Original Research article:-
*S. Emmanuel Joshua Jebasingh1, S. Rosemary1, S. Elaiyaraja1, K. Sivaraman1, M. Lakshmikandan1, A. Murugan2, P. Raja2.
1.Department of Biotechnology, Sri Paramakalyani Center for Excellence in Environmental Science, Manonmaniam Sundaranar University, Tirunelveli, Tamil nadu, India- 627412. 2.Suganthi Devadason Marine Research Institute, Tuticorin, Tamil nadu, India- 628001.
Abstract:-The seaweed species (Enteromorpha compressa, Enteromorpha intestinalis, Caulerpa scalpelliformis, Caulerpa racemosa, Chaetomorpha linum, Gracilaria foliifera, Hypnea valentiae) were collected from Gulf of Mannar, Tuticorin coast and the samples were air dried: Six different solvents (hexane, diethyl ether, chloroform, ethyl acetate, ethanol, acetone and methanol) were used for the extraction of seaweeds. The antibacterial activity of seaweed extracts was checked against six human pathogens. The acetone extract of Caulerpa scalpelliformis showed broad spectrum antibacterial activity when compared to other seaweed extracts. Acetone extract of Caulerpa scalpelliformis was further fractionated and purified using chromatographic separation techniques using bioassay guided fractionation and the active fraction purity was checked by HPLC.
Keywords:-Seaweeds, Antibacterial activity, Gulf of Mannar, Caulerpa scalpelliformis, Natural product.
Original research article:-
*Jothieswari. D1,2 , Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4,Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water. This method involves the formation and solving of simultaneous equations at 239 nm, 250 nm and 272 nm, as absorbance maxima of amlodipine besylate, valsartan and hydrochlorothiazide, respectively. Beer’s law obeyed the concentration range of 1 – 32 mcg/ mL, 4 – 40 mcg/ mL and 2 – 20 mcg/ mL for amlodipine besylate, valsartan and hydrochlorothiazide, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the simultaneous estimation of these three drugs in bulk and in combined tablet dosage form.
Keywords:- Amlodipine Besylate, Valsartan, Hydrochlorothiazide, Simultaneous equation method, Method validation.
Original research article:-
*Jothieswari. D1, 2, Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4, Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in pharmaceutical formulation using RP - C18 column. The mobile phase (acetonitrile: methanol: 50 mM phosphate buffer adjusted to pH 3 with orthophosphoric acid) was pumped at a flow rate of 1.0 mL min-1 in the ratio of 20: 50: 30% v/ v and the eluents were monitored at 239 nm. Linearity was obtained in the concentration range of 0.5 – 5 g mL-1 for amlodipine besylate, 4 - 40 g mL-1 for valsartan and 1 – 10 g mL-1 for hydrochlorothiazide. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method can be applied for determining amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in pharmaceutical dosage form.
Keywords: Amlodipine besylate, valsartan, hydrochlorothiazide, RP - HPLC.