DocumentsDate added
Review article:-
*Jain Hitesh 1, Gediya Shweta K.1, Thakkar Dadhichi K.1, Mansuri Nasimabanu Y.1, Ashar Komal M.2, Pasha T.Y.3
1.Sigma Institute of Pharmacy, Baroda, Gujarat, India.
2.Baroda medical College, Baroda, Gujarat, India.
3.Pioneer Pharmacy College, Baroda, Gujarat, India.
Abstract:-Crimean Congo hemorrhagic fever (CCHF) has the most extensive geographic distribution of the medically significant tick-borne viruses. Its causative agent is a negative-sense, single-stranded RNA virus belonging to the family Bunyaviridae, genus Nairovirus. The virus can be transmitted mainly through direct contact with blood or tissues from infected livestock or through bites of Hyalomma ticks. CCHF is a public health problem in many regions of the world, including Africa, Middle East, southern and Eastern Europe, and Western Asia. Crimean-Congo hemorrhagic fever (CCHF) virus causes a hemorrhagic and toxic syndrome disease in humans and high mortality rates of up to 50%. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase are raised, and bleeding markers are prolonged. Infection of the endothelium has a major pathogenic role. Besides direct infection of the endothelium, indirect damage by viral factors or virus-mediated host-derived soluble factors that cause endothelial activations and dysfunction are thought to occur. In diagnosis, enzyme-linked immunoassay and real-time reverse transcriptase polymerase chain reaction are used.
Key Words: Crimean haemorrhagic fever (CCHF), Nairovirus, Ribavirin.
Original research article:-
*Harika Chanda1 Palash Das1, Rahul Chakraborty 2, Arpita Ghosh 3
*1,2.Department of Pharmaceutics, MLR Institute of Pharmacy, Hyderabad, India. 1.Department of Pharmaceutics, Sri Krupa college of Pharmacy, Siddipet, India. 3.Department of Pharmaceutics, Vikas college of Pharmacy, Jangaon, India.
Abstract Aims:-The purpose of research involves to prepare the liposomes of anti fungal drug, fluconazole which were encapsulated in the form of liposomes for topical application and to improve the therapeutic response and reduce the possible adverse symptoms. Here liposomes of Fluconazole were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized for size, shape, entrapment efficiency, in-vitro drug release (by franz diffusion cell) and physical stability. The studies demonstrated successful preparation of Fluconazole liposomes and effect of soya lecithin: cholesterol weight ratio on entrapment efficiency and on drug release.
Keywords: Antifungal, liposomes, fluconazole, soya lecithin, cholesterol.
Research article:-
* M.S.S. Devi1, B.Sampath Kumar2.
1Dept of pharmacology, Chennai.India
2Professor, Dept of Pharmacology,India.
Abstract: In excision wound model Siddha kalimbu produced a significant decrease (P<0.001) in period of epithelization when compared to control. Treatment with Control skin Cream also produced significant (P<0.001) reduction in the period of epithelization. The treatment also showed significant decrease in wound contraction (50%) as compared to control. In the incision wound model, both Siddha kalimbu and Control skin Cream produced a significant increase (P<0.001) in the breaking strength of the wound when compared with the control group. Histopathology of granuloma tissue obtained from the Siddha kalimbu and Control skin Cream treated group showed a significant increase in collagen deposition with few macrophages and more fibroblasts.
Keywords: Excision wound, Control skin Cream, Histological studies, Incision wound, Siddha kalimbu.
Review article:-
*Lokendra Pal Singh1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, VijayKumar Chauhan1, Viralkumar Rana1 , Kamini S. Vasava1.
1.Department of Pharmaceutics, Parul institute of Pharmacy, Limda, Vadodara, Gujarat-391760,India.
Abstract:-In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract which includes floating drug dosage systems (FDDS) , effervescent and non effervescent system, swelling or expanding systems, mucoadhesive systems magnetic systems, modified-shape systems, high density system and other delayed gastric emptying devices. Among these systems, FDDS have been most commonly used. Effervescent FDDS are the most advantageous approach to gastric retention effervescent agent produce CO2 When come to contact with G.I fluid and support to float dosage form.
Keywords: Gastro retentive systems; Floating systems; buoyant delivery Systems; Swelling system.
Review article:-
*Preeti singh1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal1 Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:-Liver toxicity is caused by different compounds in which oxidants or free radicals plays a major role. They are very hazardous to our body by damaging the proteins, DNA, RNA and lipids, due to of this virtue. They can cause very severe diseases like Neurodegeneration, Hepatotoxicity, Aging, Cancer, Cardiovascular disease, Immune system decline and Cataract. To avoid these problems, antioxidants used, which act as free radical scavengers. Antioxidants are present naturally; endogenously (superoxide dismutase, H2O2-removing enzymes and metal binding proteins) yet they are not sufficient to prevent damaging at the oxidative stage, but dietary antioxidants (vitamin A, E, C, carotenoids and plant phenol like flavonoids) as a special nutrient. Lipid peroxidation is the major cause of hepatotoxicity caused by oxidative stress. The primary induction of hepatotoxicity is inducing level of liver enzymes as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Gamma-glutamyltransferase (GGT). Most of the mechanism of antioxidants is to decrease the elevated level of the enzymes in serum via different mechanism and in case of liver toxicity eventually to stops the lipid peroxidation. In this scenario extract of plants like Silymarin; Terminalia catappa L; Byrsocarpus coccineus and more species of plants, and their secondary metabolites are proved to be impressive useful as hepatoprotectives.
Key Words: Antioxidants; Hepatoprotectives; Free radicals; ROS; Lipid peroxidation; Oxidative stress.