DocumentsDate added
Original research article:-
*Damerakonda Kumaraswamy1, Vanga malla Reddy1 Department of Pharmaceutical Chemistry ,Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India.
Absract :The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded a single product in each case. The mannich bases obtained have been characterized as the corresponding 1-(N-Substituted amino methyl )-3-aryl-3,4-dihydro-4-oxoquinazolin-2-thione on the basis of analytical spectral data. These N-Substituted compounds have been screened for their Anti bacterial, Anti-fungal, Anti inflammatory and Analgesic activities.
Original research article:-
Monika Gupta* Department of Chemistry, University of Jammu, Jammu-180 006, India.
Abstract:-A simple and fast procedure is developed for the one-pot synthesis of novel 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines from 5-aryl-3,4-diamino-1,2,4-triazoles and acetophenone or substituted acetophenones in the presence of catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium as well as homogenizer using microwave irradiation as well as by stirring at 800C in a pre-heated oil-bath. Comparative method is simple, fast and economic and gives moderate to good yields of products and are in a state of high purity. Some of these compounds are evaluated for antifungal activity.
Keywords:-Acetophenones, triazoles, triazepines, triazolo-triazepines, N,N-dimethylformamide, p-TsOH, microwave activation.
Review article:-
Navin K. Dahiya1, *Rekha Rao1, Sanju Nanda2
1.Department of Pharmaceutics, M.M. University, Mullana, Ambala, Haryana, India-133203. 2.Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, India -124001.
Abstract:- Started in 1970’s by cosmetic scientists, the research investigations in the field of niosomal vesicular systems are increasing exponentially with growing interest in these fields. The stream of these vesicles is still in its infancy, but the explosion of interest in niosomes as inherently active therapeutic agents, as vectors for targeted delivery of drugs, peptides and hormones and able to promote oral and transdermal drug delivery makes it timely to review current knowledge regarding various aspects of niosomes. Niosomes are non-ionic surfactant based vesicles formed from the self assembly of non-ionic amphiphiles in aqueous media resulting in closed bilayer structure which can entrap both lipophilic and hydrophilic drugs. The biocompatible and biodegradable nature makes them less toxic as compared to other vesicular systems. Lower cost of niosomes is attributed to greater availability of non-ionic surfactants. These properties make them versatile carriers and interesting candidate for study. The emphasis of this review is on potential of niosomes in drug delivery applications. The composition of niosomes and especially non-ionic surfactants are discussed in detail. Preparation methods are outlined separately for these vesicular systems. In addition, this article concentrates on the success in developing niosomes as potential carriers, in this millennium.
Key words: Non-ionic surfactants, Niosomes, Liposome, Drug delivery.
Original research article:-
Goel Chirag, Verma Pankaj, Ahmad Naseer, Nailwal K Tapan* Department of Biotechnology, Kumaun University, Nainital, Campus, Bhimtal - 263136, Uttarakhand, India.
Abstract:-Urtica parviflora is considered as an important Medicinal plant, due to its various ethanomedical uses. Here, we analyze the Genetic Variation in U.parviflora, with respect to plant distribution in Kumaun hills based on change in altitude. Examination of Random amplified Polymorphic DNA (RAPD) markers from four plant samples collected at different heights from sea level indicated that genetic variation was appreciable, as samples from lower altitudes showed low genetic similarity with samples collected from higher altitudes. A total of 70 scorable bands were produced in four samples with 8 primers. The average number of bands per primer was 8.75. Out of 70 bands, 48 bands were polymorphic (68.75%) noted in the present investigation. The dendrogram of the samples showed two major clusters. The samples of Mukteshwar, Nainital and Bhowali are in one cluster and Bhimtal in other cluster.
Key words: Genetic Diversity, Primers, RAPD analysis, Taq DNA polymerase.
Research article:-
Dhatri Devi. N1, *Siddalingeshwara K.Gurubasappa1, Sunil Dutt P L N S N2, Vishwanatha T3, and Ramesha I3, Jayaramu M4, Dwarakanath V4, Naveen M5 , Sumanth B.K6.
1.Department of Microbiology and Biochemistry Padmashree Institute of Information Sciences, Nagarabhavi, Circle.Bangalore-72, India.
2.Research and Development Centre Bharathiar University, Coimbatore, India. 3.Department of Microbiology and Zoology, Maharani Science college for Women, Bangalore-01.India.
4.Department of Microbiology and Biotechnology, Tumkur University, Tumkur, India. 5.Department of Microbiology, Govt Science College, Bangalore, India.
6.Department of Biotechnology, Kuvempu University. Shankaraghatta, India.
Abstract:- Twenty one Aspergillus wentii isolates were isolated from the soil samples were screened for L-glutaminase synthesis by plate assay method. Among the isolates the potential Aspergillus wentii SD4 were used for the synthesis in elevated level of L-glutaminase by optimizing the fermentation parameters like pH, temperature and inoculums size. The optimized pH will be 5.5 and it showed 1.71 IU. Temperature and inoculums sizes were also optimized as 350C and 1.0 ml (1x107). At this level these parameters shows 2.22IU and 2.73IU in elevated levels.
Key words: Aspergillus wentii, L-glutaminase, Fermentation kinetics, tumour inhibitor.