DocumentsDate added
Review article:-
*Lokendra Pal Singh1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, VijayKumar Chauhan1, Viralkumar Rana1 , Kamini S. Vasava1.
1.Department of Pharmaceutics, Parul institute of Pharmacy, Limda, Vadodara, Gujarat-391760,India.
Abstract:-In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract which includes floating drug dosage systems (FDDS) , effervescent and non effervescent system, swelling or expanding systems, mucoadhesive systems magnetic systems, modified-shape systems, high density system and other delayed gastric emptying devices. Among these systems, FDDS have been most commonly used. Effervescent FDDS are the most advantageous approach to gastric retention effervescent agent produce CO2 When come to contact with G.I fluid and support to float dosage form.
Keywords: Gastro retentive systems; Floating systems; buoyant delivery Systems; Swelling system.
Research article:-
* M.S.S. Devi1, B.Sampath Kumar2.
1Dept of pharmacology, Chennai.India
2Professor, Dept of Pharmacology,India.
Abstract: In excision wound model Siddha kalimbu produced a significant decrease (P<0.001) in period of epithelization when compared to control. Treatment with Control skin Cream also produced significant (P<0.001) reduction in the period of epithelization. The treatment also showed significant decrease in wound contraction (50%) as compared to control. In the incision wound model, both Siddha kalimbu and Control skin Cream produced a significant increase (P<0.001) in the breaking strength of the wound when compared with the control group. Histopathology of granuloma tissue obtained from the Siddha kalimbu and Control skin Cream treated group showed a significant increase in collagen deposition with few macrophages and more fibroblasts.
Keywords: Excision wound, Control skin Cream, Histological studies, Incision wound, Siddha kalimbu.
Original research article:-
1Padmapriya, B*., 1Leema , M.C.E., 1Anishya , R.S ., 1Dhivya Prabha , R ., 1Tamilarasi.G.
1.Department of Microbiology, School of Life sciences, Karpagam University. Coimbatore.21, TamilNadu, India.
Abstract:-According to World Health Report of Infectious diseases 2000, overcoming antibiotic resistance is the major issue of the WHO for the next millennium. Hence the last decade witnessed an increase in the investigation of plants as a source of human disease management. The aim of the present study was to investigate antibacterial activity of the various extracts of Hibiscus sabdariffa and Solanum trilobatum. The powdered plant leaves materials were extracted in n-hexane, chloroform, ethyl acetate, ethanol and water and their antibacterial activities were examined against some collected clinical isolates using agar dilution method. The qualitative screening of phytochemical compounds of H. sabdariffa and S.trilobatum were performed. Ethanolic extract of Hibiscus sabdariffa and hexane extract of Solanum trilobatum gave the highest inhibition against all the urinary isolates. The presence of starch, proteins, aminoacids, steroids, cardiac glycosides, saponin glycosides, coumarin glycosides, flavanoids, tannins ,phenolic compounds and the presence of steroids, cardiac glycosides and coumarin glycosides, aminoacids and flavanoids were observed in the phytochemical screening of H. sabdariffa and S. trilobatum extracts respectively. These findings reveals that antimicrobial activity especially against the urinary pathogens of the selected plant extracts may be due to the presence of these phytochemicals. The spectra of activities displayed by the extract signifies the potency of Hibiscus sabdariffa and Solanum trilobatum as a source of therapeutic agents and may provide leads in the on going search for antimicrobial agent from plants.
Keywords: Antimicrobial, Ethanolic extract, Hibiscus sabdariffa, phytocemical properties, Solanum trilobatum, Uropathogens.
Original research article:-
Tanuja Shailesh1, Dinesh Acharya U2, * Shailesh K R3
1,2.Dept. of CSE, MIT, Manipal University, Karnataka ,India.
3.Dept. of E & E, MIT, Manipal University, Karnataka , India.
Abstract:-Data mining has a wide use in the healthcare domain in areas such as diagnoses and patient management. One of the main concerns in the healthcare area is the measurement of flow of patients through hospitals and other health care facilities. For instance if the inpatient length of stay (LOS) can be predicted efficiently, the planning and management of hospital resources can be greatly enhanced. Hospital LOS of inpatients is frequently used as a proxy for measuring the consumption of hospital resources and therefore it is essential to develop accurate models for the prediction of inpatients LOS. In this paper we apply text mining techniques to pre-process the text data of electronic discharge summaries available in HTML format and apply traditional data mining techniques such as k-means clustering to analyze the textual information for classifying discharge summaries based on disease and patient’s length of stay in the hospital.
Keywords: Text mining, Discharge Summary, Regular Expression, feature extraction, Pattern recognition, length of stay, K-Means.
Original research article:-
*Veerendra K. Nanjwade1, F. V. Manvi1, Shamrez Ali. M2, Basavaraj K. Nanjwade1
1.Department of Pharmaceutics, KLE University College of Pharmacy, JN Medical College Campus, Belgaum – 590010, Karnataka, India.
2.Simpex Pharma Pvt. Ltd, Sigaadi, Kotdwara – 246149, Pauri Garhwal, Uttarakhand, India.
Abstract:-Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development.
Objective: In this study, we aimed to characterize the of Prulifloxacin-salicylic acid cocrystals by IR, DSC and PXRD in comparision with the pure drug.
Materials and Methods: Pharmaceutical cocrystals were prepared by the kneading method with aid of salicylic acid and urea as coformer. The cocrystals were subjected to various physicochemical studies and thermal methods.
Results and Discussion: The cocrystal of prulifloxacin , with salisylic acid (SA) has been shown to have higher solubility than prulifloxacin. In this study, we aimed to characterize the pure drug and the cocrystals with the salicylic acid and urea. Remarkably, two new cocrystals of prulifloxacin were discovered in this study. The study indicates that the improved aqueous solubility of the cocrystals leads to improved dissolution of Prulifloxacin. Thus, the cocrystals are a viable alternative solid form that can improve the dissolution rate and bioavailability of poorly soluble drugs.
Conclusion: Subsequently, differential scanning calorimetry was used to investigate the cocrystal formation. The formation of cocrystals was also verified using liquid-assisted grinding. The spectral patterns of prulifloxacin , salicylic acid and the complex were different.The physicochemical properties such as solubility and dissolution rate of this complex will be further investigated.
Key words: Pharmaceutical cocrystlas, Prulifloxacin, Salicylic acid, Complex.