DocumentsDate added
Original research article:-
*Damerakonda Kumaraswamy1,Vanga mallareddy2
1.Department of Pharmaceutical Chemistry,Vaagdevi College of Pharmacy,Hanamkonda,Warangal, Andhrapradesh,India.
2.Department of Medicinal Chemistry, Devis lab,Research and Development unit,Hyderabad, Andhrapradesh. India.
Abstract:-The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded asingle product in each case.The mannich bases obtained have been characterized as the corresponding 2-S-substituted amino methyl thio-3-aryl 4(3H) quinazolinone(VI) on the basis of analytical spectral data.These S-Substituted compounds have been screened for their Anti- bacterial,Anti -fungal,Anti- inflammatory and Analgesic activities.
Original research article:-
*Damerakonda Kumaraswamy1, Vanga malla Reddy1 Department of Pharmaceutical Chemistry ,Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India.
Absract :The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded a single product in each case. The mannich bases obtained have been characterized as the corresponding 1-(N-Substituted amino methyl )-3-aryl-3,4-dihydro-4-oxoquinazolin-2-thione on the basis of analytical spectral data. These N-Substituted compounds have been screened for their Anti bacterial, Anti-fungal, Anti inflammatory and Analgesic activities.
Review article:-
*Umashankar Lakshmanadoss1, Monika Moni1, Priya Chinnachamy 2 1.Division of Hospital Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD1, USA.
2.All India Institute of Medical Sciences, New Delhi, India.
Abstract:-Blood transfusion is one of the common interventions done in the hospital setting on a daily basis. Complications of blood transfusions are becoming rare, thanks to the advanced technology. However, just because of the total number of transfusions, medical and paramedical persons may encounter these situations more often than thought. Complications related to blood transfusion may be divided in to acute and delayed transfusion reactions based on the time of presentations. Acute reaction ranges from allergic reactions and febrile nonhemolytic reactions which are benign to febrile hemolytic reactions which could be life threatening. In addition to these febrile reaction, development of hypoxia after transfusion is always concerning as this could be a manifestation of circulatory volume overload or Transfusion Related Lung Injury (TRALI). Differentiating TRALI from circulatory volume overload is very important as diuretics are indicated in circulatory overload and they are not useful in TRALI. Transfusion related infections are rare nowadays thanks to the advanced technology. Most common cause of blood transfusion errors are due to human errors. Transfusion is a multistep procedure and needs a constant vigil at various levels to prevent these complications. A unique barcode on each patient’s wristband is used to identify the patient’s cross-match blood samples and each unit of blood prepared for that patient. This program have been tested and implemented successfully in various institutions including the author's institution (UL). Here, we are presenting a patient who developed TRALI following blood transfusion. In this article, we also reviewed the complications of blood transfusion, ways to prevent them and their management.
Original research article:-
*Salah I. Kheder, Idris Eltayeb, Sania A I Shaddad, Isam Kheder.
*Ph.D Pharmacology-National College of Medical & Techenical sciencies, Deputy Pharmacy Program Co-ordinator,Pharmacy program,Khartoum-3783,Sudan.
Abstract:-Background: Antimicrobial resistance is one of the biggest challenges facing global public health. In the past sixty years, many classes of antimicrobial have been developed, but duration of benefit appeared to be limited: resistance has emerged to every antimicrobial class. Antimicrobial resistance seriously hampers treatment of infections and leads to increased length of stay, morbidity, mortality and healthcare costs, both in hospital and community settings. In the era of increasing bacterial resistance and in the absence of new effective antibacterial drugs, it is necessary to use the currently available agents optimally and appropriately. Of the interventions designed to reduce antibiotic resistant rates in hospitals, where antibiotic usage is high, is antibiotic cycling or rotation.
Method: A prospective quasi-experimental (pre & post intervention), nonrandomized, observational study, conducted in Ibn Sina Hospital at two surgical wards (Gastro-intestinal tract & Urology surgical wards), to evaluate the impact of antimicrobial cycling intervention in the prevalence of antimicrobial-resistance bacteria. Three antibiotic classes (cephalosporin, amoxiclave and ciprofloxacin) were systematically cycled for 3-4 months intervals over 2 years. Colonization with antibiotic-resistance bacteria was determined with intensive surveillance, through cultured a bacterial isolates taken from surgical wounds and urine and sensitivity test were performed for susceptibility.
Results: In all, 1681 surveillance samples obtained from 2359 eligible patients admitted to the Ibn Sina hospital. Of these samples 345 (20.5%) obtained from GIT ward as surgical and wound swabs, 1336 (79.5%) samples obtained from urology surgical ward (1197 urine samples and 139 surgical swabs). A decrease in the mortality rate was observed when comparing between the baseline period and most of the cyclic periods for each ward, but with no significant difference. Length of stay decreased from baseline period to cyclic period for each ward (GIT 13.3± 11.8 Vs 9.6± 8.7 ,p ≤ 0.229 ; Urology 11.9± 12.42 Vs 7.1± 5.5 p≤ 0.204).As general we notice that there is a divergent effect of the antimicrobial cycling on the prevalence of bacterial resistance. A slight decrease in mean resistance percentage, (R %) for all gram-positive bacteria (GPB) between baseline and cycle (VI) in GIT ward (decreased from 79% to 73%), while there is increase in mean (R %) for all gram-negative bacteria (GNB) for the same ward during same period (increased from 89% to 100%). In urology ward an increase in mean (R%) for GPB between baseline and cycle (VI) (increased from 81% to 97%),but a decrease in mean (R%) GNB for the same ward during the same period (decreased from 88% to 78%).
Conclusion: After two years follow-up our study was successes to stabilize antibiotic resistance, without significant reduction, especially when we put in consideration that the physicians' adherence to only the use of the cycled antimicrobial was poor and also erratic.
Key words: antibiotic resistance; antibiotic cycling; antibiotic rotation, antibiotic policy.
Research article:-
* M.S.S. Devi1, B.Sampath Kumar2.
1Dept of pharmacology, Chennai.India
2Professor, Dept of Pharmacology,India.
Abstract: In excision wound model Siddha kalimbu produced a significant decrease (P<0.001) in period of epithelization when compared to control. Treatment with Control skin Cream also produced significant (P<0.001) reduction in the period of epithelization. The treatment also showed significant decrease in wound contraction (50%) as compared to control. In the incision wound model, both Siddha kalimbu and Control skin Cream produced a significant increase (P<0.001) in the breaking strength of the wound when compared with the control group. Histopathology of granuloma tissue obtained from the Siddha kalimbu and Control skin Cream treated group showed a significant increase in collagen deposition with few macrophages and more fibroblasts.
Keywords: Excision wound, Control skin Cream, Histological studies, Incision wound, Siddha kalimbu.