DocumentsDate added
Original research article:-
1Padmapriya, B*., 1Leema , M.C.E., 1Anishya , R.S ., 1Dhivya Prabha , R ., 1Tamilarasi.G.
1.Department of Microbiology, School of Life sciences, Karpagam University. Coimbatore.21, TamilNadu, India.
Abstract:-According to World Health Report of Infectious diseases 2000, overcoming antibiotic resistance is the major issue of the WHO for the next millennium. Hence the last decade witnessed an increase in the investigation of plants as a source of human disease management. The aim of the present study was to investigate antibacterial activity of the various extracts of Hibiscus sabdariffa and Solanum trilobatum. The powdered plant leaves materials were extracted in n-hexane, chloroform, ethyl acetate, ethanol and water and their antibacterial activities were examined against some collected clinical isolates using agar dilution method. The qualitative screening of phytochemical compounds of H. sabdariffa and S.trilobatum were performed. Ethanolic extract of Hibiscus sabdariffa and hexane extract of Solanum trilobatum gave the highest inhibition against all the urinary isolates. The presence of starch, proteins, aminoacids, steroids, cardiac glycosides, saponin glycosides, coumarin glycosides, flavanoids, tannins ,phenolic compounds and the presence of steroids, cardiac glycosides and coumarin glycosides, aminoacids and flavanoids were observed in the phytochemical screening of H. sabdariffa and S. trilobatum extracts respectively. These findings reveals that antimicrobial activity especially against the urinary pathogens of the selected plant extracts may be due to the presence of these phytochemicals. The spectra of activities displayed by the extract signifies the potency of Hibiscus sabdariffa and Solanum trilobatum as a source of therapeutic agents and may provide leads in the on going search for antimicrobial agent from plants.
Keywords: Antimicrobial, Ethanolic extract, Hibiscus sabdariffa, phytocemical properties, Solanum trilobatum, Uropathogens.
Research article:-
* M.S.S. Devi1, B.Sampath Kumar2.
1Dept of pharmacology, Chennai.India
2Professor, Dept of Pharmacology,India.
Abstract: In excision wound model Siddha kalimbu produced a significant decrease (P<0.001) in period of epithelization when compared to control. Treatment with Control skin Cream also produced significant (P<0.001) reduction in the period of epithelization. The treatment also showed significant decrease in wound contraction (50%) as compared to control. In the incision wound model, both Siddha kalimbu and Control skin Cream produced a significant increase (P<0.001) in the breaking strength of the wound when compared with the control group. Histopathology of granuloma tissue obtained from the Siddha kalimbu and Control skin Cream treated group showed a significant increase in collagen deposition with few macrophages and more fibroblasts.
Keywords: Excision wound, Control skin Cream, Histological studies, Incision wound, Siddha kalimbu.
Review article:-
*Lokendra Pal Singh1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, VijayKumar Chauhan1, Viralkumar Rana1 , Kamini S. Vasava1.
1.Department of Pharmaceutics, Parul institute of Pharmacy, Limda, Vadodara, Gujarat-391760,India.
Abstract:-In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract which includes floating drug dosage systems (FDDS) , effervescent and non effervescent system, swelling or expanding systems, mucoadhesive systems magnetic systems, modified-shape systems, high density system and other delayed gastric emptying devices. Among these systems, FDDS have been most commonly used. Effervescent FDDS are the most advantageous approach to gastric retention effervescent agent produce CO2 When come to contact with G.I fluid and support to float dosage form.
Keywords: Gastro retentive systems; Floating systems; buoyant delivery Systems; Swelling system.
Original research article:-
*Jothieswari. D1, 2, Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4, Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in pharmaceutical formulation using RP - C18 column. The mobile phase (acetonitrile: methanol: 50 mM phosphate buffer adjusted to pH 3 with orthophosphoric acid) was pumped at a flow rate of 1.0 mL min-1 in the ratio of 20: 50: 30% v/ v and the eluents were monitored at 239 nm. Linearity was obtained in the concentration range of 0.5 – 5 g mL-1 for amlodipine besylate, 4 - 40 g mL-1 for valsartan and 1 – 10 g mL-1 for hydrochlorothiazide. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method can be applied for determining amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in pharmaceutical dosage form.
Keywords: Amlodipine besylate, valsartan, hydrochlorothiazide, RP - HPLC.
Original research article:-
*Jothieswari. D1,2 , Anandakumar. K2, Vijaya Santhi. D3, Vijayakumar. B4, Priya. D4,Stephen Rathinaraj. B5
1.Department of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
2.Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.
3.Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
4.Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
5.Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Abstract:- A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of amlodipine besylate, valsartan and hydrochlorothiazide in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water. This method involves the formation and solving of simultaneous equations at 239 nm, 250 nm and 272 nm, as absorbance maxima of amlodipine besylate, valsartan and hydrochlorothiazide, respectively. Beer’s law obeyed the concentration range of 1 – 32 mcg/ mL, 4 – 40 mcg/ mL and 2 – 20 mcg/ mL for amlodipine besylate, valsartan and hydrochlorothiazide, respectively. The results of analysis were validated statistically and by recovery studies. The % RSD for the recovery study was less than 2. The proposed method can be effectively applied for the simultaneous estimation of these three drugs in bulk and in combined tablet dosage form.
Keywords:- Amlodipine Besylate, Valsartan, Hydrochlorothiazide, Simultaneous equation method, Method validation.