DocumentsDate added
Review article:-
*Baiju Gopalan Nair 1 K Amarendhar Reddy 1, Naga Lakshmi Reddy 1, Upendranath Reddy1
1Department of Conservative Dentistry & Endodontics,G Pulla Reddy Dental College & Hospital, Kurnool ,Andhrapradesh, India.
Abstract:-The success in endodontics depends on complete eradication of microbes from the root canal system which effectively prevents re infection. the introduction of rotary instruments help the canal preparation more effective especially in the apical third, there by helping the effectiveness of the irrigants to penetrate till the root apex. This helped to control the microbial level at the apical third of the root canals. The irrigants which use to be delivered using the traditional methods like syringes and needles of different size and tip design prove d to be ineffective. In the recent years, chemical composition of irrigants and mechanical devices which helps in irrigation has been improved leaps and bounds. This article summarizes the recent developments for the safe and effective irrigation which ultimately helps to minimize the bacterial levels resulting in successive endodontic therapy.
Key words:-Root canal Irrigants, Root canal disinfection, Smear layer, Endovac- irrigating system, PUI, Lasers, Quantec-e irrigation system, Bioglasses, Ozone therapy.
Original research article:-
1Padmapriya, B*., 1Leema , M.C.E., 1Anishya , R.S ., 1Dhivya Prabha , R ., 1Tamilarasi.G.
1.Department of Microbiology, School of Life sciences, Karpagam University. Coimbatore.21, TamilNadu, India.
Abstract:-According to World Health Report of Infectious diseases 2000, overcoming antibiotic resistance is the major issue of the WHO for the next millennium. Hence the last decade witnessed an increase in the investigation of plants as a source of human disease management. The aim of the present study was to investigate antibacterial activity of the various extracts of Hibiscus sabdariffa and Solanum trilobatum. The powdered plant leaves materials were extracted in n-hexane, chloroform, ethyl acetate, ethanol and water and their antibacterial activities were examined against some collected clinical isolates using agar dilution method. The qualitative screening of phytochemical compounds of H. sabdariffa and S.trilobatum were performed. Ethanolic extract of Hibiscus sabdariffa and hexane extract of Solanum trilobatum gave the highest inhibition against all the urinary isolates. The presence of starch, proteins, aminoacids, steroids, cardiac glycosides, saponin glycosides, coumarin glycosides, flavanoids, tannins ,phenolic compounds and the presence of steroids, cardiac glycosides and coumarin glycosides, aminoacids and flavanoids were observed in the phytochemical screening of H. sabdariffa and S. trilobatum extracts respectively. These findings reveals that antimicrobial activity especially against the urinary pathogens of the selected plant extracts may be due to the presence of these phytochemicals. The spectra of activities displayed by the extract signifies the potency of Hibiscus sabdariffa and Solanum trilobatum as a source of therapeutic agents and may provide leads in the on going search for antimicrobial agent from plants.
Keywords: Antimicrobial, Ethanolic extract, Hibiscus sabdariffa, phytocemical properties, Solanum trilobatum, Uropathogens.
Original research article:-
Monika Gupta* Department of Chemistry, University of Jammu, Jammu-180 006, India.
Abstract:-A simple and fast procedure is developed for the one-pot synthesis of novel 8-methyl-3,6,8-trisubstituted-7H,9H-[1,2,4]triazolo[4,3-b][1,2,4]triazepines from 5-aryl-3,4-diamino-1,2,4-triazoles and acetophenone or substituted acetophenones in the presence of catalytic amount of p-TsOH and N,N-dimethylformamide as an energy transfer medium as well as homogenizer using microwave irradiation as well as by stirring at 800C in a pre-heated oil-bath. Comparative method is simple, fast and economic and gives moderate to good yields of products and are in a state of high purity. Some of these compounds are evaluated for antifungal activity.
Keywords:-Acetophenones, triazoles, triazepines, triazolo-triazepines, N,N-dimethylformamide, p-TsOH, microwave activation.
Review article:-
*Preeti singh1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal1 Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:-Liver toxicity is caused by different compounds in which oxidants or free radicals plays a major role. They are very hazardous to our body by damaging the proteins, DNA, RNA and lipids, due to of this virtue. They can cause very severe diseases like Neurodegeneration, Hepatotoxicity, Aging, Cancer, Cardiovascular disease, Immune system decline and Cataract. To avoid these problems, antioxidants used, which act as free radical scavengers. Antioxidants are present naturally; endogenously (superoxide dismutase, H2O2-removing enzymes and metal binding proteins) yet they are not sufficient to prevent damaging at the oxidative stage, but dietary antioxidants (vitamin A, E, C, carotenoids and plant phenol like flavonoids) as a special nutrient. Lipid peroxidation is the major cause of hepatotoxicity caused by oxidative stress. The primary induction of hepatotoxicity is inducing level of liver enzymes as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Gamma-glutamyltransferase (GGT). Most of the mechanism of antioxidants is to decrease the elevated level of the enzymes in serum via different mechanism and in case of liver toxicity eventually to stops the lipid peroxidation. In this scenario extract of plants like Silymarin; Terminalia catappa L; Byrsocarpus coccineus and more species of plants, and their secondary metabolites are proved to be impressive useful as hepatoprotectives.
Key Words: Antioxidants; Hepatoprotectives; Free radicals; ROS; Lipid peroxidation; Oxidative stress.
Review article:- 1Kinja Kuldeep*, 1Patel Hiten, 1Gupta Nakul
1.NIMS Institute of Pharmacy, Shobha Nagar, Jaipur-303121 Rajasthan, India.
Abstract Genetic disorders are either hereditary disorders or a result of mutations. Some disorders may confer an advantage, at least in certain environments. A genetic disorder is an illness caused by abnormalities in genes or chromosomes. Most disorders are quite rare and affect one person in every several thousands or millions. Some types of recessive gene disorders confer an advantage in the heterozygous state in certain environments. Genetic disorders rarely have effective treatments, though gene therapy is being tested as a possible treatment for some genetic diseases. There are mainly two types of genetic disorders are there. These are Single gene disorder and multifactorial and polygenic (complex) disorders. Single gene disorders are again of different types- Autosomal dominant, Autosomal recessive, X-linked dominant, X-linked recessive, Y-linked and Mitochondrial. Currently around 4,000 genetic disorders are known, with more being discovered. Most disorders are quite rare and affect one person in every several thousands or millions. In this article we only discussed about main four hereditary disorders which are having a high mortality and occurrence rate. These are Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Key Words: Hereditary, Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.