DocumentsDate added
Review article:-
Puratchikody A 1, *Swarnalatha S 2
1.Department of Pharmaceutical Technology, AnnaUniversity, Tiruchirappalli – 620 024, India.
2.K.R.S Pallavan College of Pharmacy, Thandalam, Chennai – 602 105, India .
Abstract:-Many herbal remedies have been employed in various medicinal systems for the treatment and management of different diseases .The Indigofera Asplathoides commonly known as “Sivanar Vembu” has been recognized in different system of traditional medicines for the treatment of different diseases and ailments of human beings. This review supports all updated information on its pharmacognosy, pharmacological activity and traditional uses. Preliminary phytochemical screening of this plant revealed the presence of tannins, flavonoids, alkaloids, glycoside, and steroids. It has been reported as anticancer, antimicrobial, hepatoprotective, hypoglycemic, antioxidant, antibacterial, antiviral, anti-inflammatory, antineoplastic activity. The leaves, flowers and tender shoots of the plant were said to be cooling and demulcent and are employed as a decoction in leprosy and cancerous infections. There is no report available on isolated constituents of bioactive compound from whole plants Indigofera Aspalathoides which support its further to isolating a useful pharmacologically active compound as a drug.
Key words:- Indigofera Aspalathoides, Sivanar vembu, Pharmacognostical, Pharmacological, Traditional uses.
Original research article:-
1Padmapriya, B*., 1Leema , M.C.E., 1Anishya , R.S ., 1Dhivya Prabha , R ., 1Tamilarasi.G.
1.Department of Microbiology, School of Life sciences, Karpagam University. Coimbatore.21, TamilNadu, India.
Abstract:-According to World Health Report of Infectious diseases 2000, overcoming antibiotic resistance is the major issue of the WHO for the next millennium. Hence the last decade witnessed an increase in the investigation of plants as a source of human disease management. The aim of the present study was to investigate antibacterial activity of the various extracts of Hibiscus sabdariffa and Solanum trilobatum. The powdered plant leaves materials were extracted in n-hexane, chloroform, ethyl acetate, ethanol and water and their antibacterial activities were examined against some collected clinical isolates using agar dilution method. The qualitative screening of phytochemical compounds of H. sabdariffa and S.trilobatum were performed. Ethanolic extract of Hibiscus sabdariffa and hexane extract of Solanum trilobatum gave the highest inhibition against all the urinary isolates. The presence of starch, proteins, aminoacids, steroids, cardiac glycosides, saponin glycosides, coumarin glycosides, flavanoids, tannins ,phenolic compounds and the presence of steroids, cardiac glycosides and coumarin glycosides, aminoacids and flavanoids were observed in the phytochemical screening of H. sabdariffa and S. trilobatum extracts respectively. These findings reveals that antimicrobial activity especially against the urinary pathogens of the selected plant extracts may be due to the presence of these phytochemicals. The spectra of activities displayed by the extract signifies the potency of Hibiscus sabdariffa and Solanum trilobatum as a source of therapeutic agents and may provide leads in the on going search for antimicrobial agent from plants.
Keywords: Antimicrobial, Ethanolic extract, Hibiscus sabdariffa, phytocemical properties, Solanum trilobatum, Uropathogens.
Review article:-
Navin K. Dahiya1, *Rekha Rao1, Sanju Nanda2
1.Department of Pharmaceutics, M.M. University, Mullana, Ambala, Haryana, India-133203. 2.Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, India -124001.
Abstract:- Started in 1970’s by cosmetic scientists, the research investigations in the field of niosomal vesicular systems are increasing exponentially with growing interest in these fields. The stream of these vesicles is still in its infancy, but the explosion of interest in niosomes as inherently active therapeutic agents, as vectors for targeted delivery of drugs, peptides and hormones and able to promote oral and transdermal drug delivery makes it timely to review current knowledge regarding various aspects of niosomes. Niosomes are non-ionic surfactant based vesicles formed from the self assembly of non-ionic amphiphiles in aqueous media resulting in closed bilayer structure which can entrap both lipophilic and hydrophilic drugs. The biocompatible and biodegradable nature makes them less toxic as compared to other vesicular systems. Lower cost of niosomes is attributed to greater availability of non-ionic surfactants. These properties make them versatile carriers and interesting candidate for study. The emphasis of this review is on potential of niosomes in drug delivery applications. The composition of niosomes and especially non-ionic surfactants are discussed in detail. Preparation methods are outlined separately for these vesicular systems. In addition, this article concentrates on the success in developing niosomes as potential carriers, in this millennium.
Key words: Non-ionic surfactants, Niosomes, Liposome, Drug delivery.
Research article:-
Dhatri Devi. N1, *Siddalingeshwara K.Gurubasappa1, Sunil Dutt P L N S N2, Vishwanatha T3, and Ramesha I3, Jayaramu M4, Dwarakanath V4, Naveen M5 , Sumanth B.K6.
1.Department of Microbiology and Biochemistry Padmashree Institute of Information Sciences, Nagarabhavi, Circle.Bangalore-72, India.
2.Research and Development Centre Bharathiar University, Coimbatore, India. 3.Department of Microbiology and Zoology, Maharani Science college for Women, Bangalore-01.India.
4.Department of Microbiology and Biotechnology, Tumkur University, Tumkur, India. 5.Department of Microbiology, Govt Science College, Bangalore, India.
6.Department of Biotechnology, Kuvempu University. Shankaraghatta, India.
Abstract:- Twenty one Aspergillus wentii isolates were isolated from the soil samples were screened for L-glutaminase synthesis by plate assay method. Among the isolates the potential Aspergillus wentii SD4 were used for the synthesis in elevated level of L-glutaminase by optimizing the fermentation parameters like pH, temperature and inoculums size. The optimized pH will be 5.5 and it showed 1.71 IU. Temperature and inoculums sizes were also optimized as 350C and 1.0 ml (1x107). At this level these parameters shows 2.22IU and 2.73IU in elevated levels.
Key words: Aspergillus wentii, L-glutaminase, Fermentation kinetics, tumour inhibitor.
Original research article:-
*Damerakonda Kumaraswamy1, Vanga malla Reddy1 Department of Pharmaceutical Chemistry ,Vaagdevi College of Pharmacy, Warangal, Andhrapradesh, India.
Absract :The Mannich reaction on 3-Aryl-3,4-di hydro-4-oxoquinazolin-2-thione with different secondary amines yielded a single product in each case. The mannich bases obtained have been characterized as the corresponding 1-(N-Substituted amino methyl )-3-aryl-3,4-dihydro-4-oxoquinazolin-2-thione on the basis of analytical spectral data. These N-Substituted compounds have been screened for their Anti bacterial, Anti-fungal, Anti inflammatory and Analgesic activities.