DocumentsDate added
Original research article:-
*Harika Chanda1 Palash Das1, Rahul Chakraborty 2, Arpita Ghosh 3
*1,2.Department of Pharmaceutics, MLR Institute of Pharmacy, Hyderabad, India. 1.Department of Pharmaceutics, Sri Krupa college of Pharmacy, Siddipet, India. 3.Department of Pharmaceutics, Vikas college of Pharmacy, Jangaon, India.
Abstract Aims:-The purpose of research involves to prepare the liposomes of anti fungal drug, fluconazole which were encapsulated in the form of liposomes for topical application and to improve the therapeutic response and reduce the possible adverse symptoms. Here liposomes of Fluconazole were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized for size, shape, entrapment efficiency, in-vitro drug release (by franz diffusion cell) and physical stability. The studies demonstrated successful preparation of Fluconazole liposomes and effect of soya lecithin: cholesterol weight ratio on entrapment efficiency and on drug release.
Keywords: Antifungal, liposomes, fluconazole, soya lecithin, cholesterol.
Review article:-
*Baiju Gopalan Nair 1 K Amarendhar Reddy 1, Naga Lakshmi Reddy 1, Upendranath Reddy1
1Department of Conservative Dentistry & Endodontics,G Pulla Reddy Dental College & Hospital, Kurnool ,Andhrapradesh, India.
Abstract:-The success in endodontics depends on complete eradication of microbes from the root canal system which effectively prevents re infection. the introduction of rotary instruments help the canal preparation more effective especially in the apical third, there by helping the effectiveness of the irrigants to penetrate till the root apex. This helped to control the microbial level at the apical third of the root canals. The irrigants which use to be delivered using the traditional methods like syringes and needles of different size and tip design prove d to be ineffective. In the recent years, chemical composition of irrigants and mechanical devices which helps in irrigation has been improved leaps and bounds. This article summarizes the recent developments for the safe and effective irrigation which ultimately helps to minimize the bacterial levels resulting in successive endodontic therapy.
Key words:-Root canal Irrigants, Root canal disinfection, Smear layer, Endovac- irrigating system, PUI, Lasers, Quantec-e irrigation system, Bioglasses, Ozone therapy.