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Review article:-
*VijayKumar Chauhan1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, Lokendra Pal Singh1, Khushbu Shah1, Kuldipsinh Pagi1.
1.Department of Pharmaceutics, Parul Institute of Pharmacy, Limda, Vadodara, Gujarat-391760, India.
Abstract:-Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (MDTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self administration without water or chewing. This novel type of delivery system offers convenience for treatment-resistant population who have difficulty in swallowing unit oral dosage form, namely Tablets and Capsules. These formulations are particularly beneficial to pediatric and geriatric patients. It is estimated that 50 % of the population is affected by dysphagia which results in high incidence of non-compliance and ineffective therapy. The aim of this article is to review the ideal properties, significance, characteristics, limitation, choice of drug candidates, challenges in formulation, approaches for preparation of MDTs, Patented technologies on MDTs, Suitable drug candidates for MDTs, Marketed product of MDTs, and Evaluation tests of MDTs.
Key words: Fast disintegrating, Mouth Dissolving Tablet, Dysphagia.
Review article:- 1Kinja Kuldeep*, 1Patel Hiten, 1Gupta Nakul
1.NIMS Institute of Pharmacy, Shobha Nagar, Jaipur-303121 Rajasthan, India.
Abstract Genetic disorders are either hereditary disorders or a result of mutations. Some disorders may confer an advantage, at least in certain environments. A genetic disorder is an illness caused by abnormalities in genes or chromosomes. Most disorders are quite rare and affect one person in every several thousands or millions. Some types of recessive gene disorders confer an advantage in the heterozygous state in certain environments. Genetic disorders rarely have effective treatments, though gene therapy is being tested as a possible treatment for some genetic diseases. There are mainly two types of genetic disorders are there. These are Single gene disorder and multifactorial and polygenic (complex) disorders. Single gene disorders are again of different types- Autosomal dominant, Autosomal recessive, X-linked dominant, X-linked recessive, Y-linked and Mitochondrial. Currently around 4,000 genetic disorders are known, with more being discovered. Most disorders are quite rare and affect one person in every several thousands or millions. In this article we only discussed about main four hereditary disorders which are having a high mortality and occurrence rate. These are Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.
Key Words: Hereditary, Neurofibromatosis, Charcot-Marie-Tooth disease (CMT), Haemophilia and Sickle Cell Anaemia.