DocumentsDate added
Review article:-
A B Roge*, S N Firke, S B Gaikwad, V N Gunjkar, Dr. S M Vadvalkar Pharmaceutical Chemistry Department, Nanded Pharmacy College, Shyam Nagar, Nanded,India.
Abstract:-Bioadhesion is the relatively new and emerging concept in drug delivery, Bioadhesion keeps the delivery system adhering to the mucus membrane. Transmucosal drug delivery systems show various merits over conventional drug delivery systems. Bioadhesive polymers facilitate the bioadhesion by their specific properties. In transmucosal drug delivery system, bioadhesive polymer plays major role along with active ingredients. Bioadhesive polymers that adhere to the mucin epithelial surface are effective and lead to significant improvement in drug delivery system. Improvements are also expected for other mucus-covered sites of drug administration. Bioadhesive polymers find application in the eye, nose, and vaginal cavity as well as in the GI tract, including the buccal cavity and rectum. This review focus on Bioadhesion, Important Factors of Bioadhesion, Ideal Characteristics, Classification, Description and Application of bioadhesive polymer.
Keywords:-Bioadhesion, Mucin, Rectum, Transmucosal drug delivery systems.
Original research article:-
* Mrs. G. Indira1,Prof G.Raghuramulu1, Prof.S.Ramreddy2, Prof.Kondal Rao3.
1* Asst Prof .in microbiology, Dept. of Microbiology. Pingle govt Degree and PG college,Warangal ,Andhra Pradesh, India.
1.Dept. of Zoology, Kakatiya university, Warangal, Andhra Pradesh,India.
2.Dept. of Microbiology, Kakatiya university, Warangal, Andhra Pradesh, India.
3.Dept. of Microbiology, Kakatiya Medical College, Warangal, Andhra Pradesh, India.
Abstract:-Trichophyton is the commonest dermatophyte which is geophilic, zoophilic and anthrophilic in nature. The genus Trichophyton includes 24 species; some of these are saprophytes. The most common human pathogenic species of Tricophyton genus are T.mentagrophytes 1 and T.rubrum2. These causes tinea corporis, tinea cruris, tinea pedis, tinea capitis, tinea unguium by infecting skin, hair and nail respectively. The two species can be differentiated on the basis of biochemical tests like urease test 3 invitro hair perforation test4 . These are also identified on the culture characters like macro and micro conidia. These rarely produce macro conidia which may be clavate or cigar shaped or elongated, pencil shaped. Microconidia are abundant and may be globose or pyri form and are born singly along the sides of hyphae or in grape like clusters. Key Words: Trichophyton mentagrophytes, T.rubrum, Sabouraud agar medium, urease test, hair perforation test, microconidia .
Review article:-
Puratchikody A 1, *Swarnalatha S 2
1.Department of Pharmaceutical Technology, AnnaUniversity, Tiruchirappalli – 620 024, India.
2.K.R.S Pallavan College of Pharmacy, Thandalam, Chennai – 602 105, India .
Abstract:-Many herbal remedies have been employed in various medicinal systems for the treatment and management of different diseases .The Indigofera Asplathoides commonly known as “Sivanar Vembu” has been recognized in different system of traditional medicines for the treatment of different diseases and ailments of human beings. This review supports all updated information on its pharmacognosy, pharmacological activity and traditional uses. Preliminary phytochemical screening of this plant revealed the presence of tannins, flavonoids, alkaloids, glycoside, and steroids. It has been reported as anticancer, antimicrobial, hepatoprotective, hypoglycemic, antioxidant, antibacterial, antiviral, anti-inflammatory, antineoplastic activity. The leaves, flowers and tender shoots of the plant were said to be cooling and demulcent and are employed as a decoction in leprosy and cancerous infections. There is no report available on isolated constituents of bioactive compound from whole plants Indigofera Aspalathoides which support its further to isolating a useful pharmacologically active compound as a drug.
Key words:- Indigofera Aspalathoides, Sivanar vembu, Pharmacognostical, Pharmacological, Traditional uses.
Review article:-
*Jain Hitesh 1, Gediya Shweta K.1, Thakkar Dadhichi K.1, Mansuri Nasimabanu Y.1, Ashar Komal M.2, Pasha T.Y.3
1.Sigma Institute of Pharmacy, Baroda, Gujarat, India.
2.Baroda medical College, Baroda, Gujarat, India.
3.Pioneer Pharmacy College, Baroda, Gujarat, India.
Abstract:-Crimean Congo hemorrhagic fever (CCHF) has the most extensive geographic distribution of the medically significant tick-borne viruses. Its causative agent is a negative-sense, single-stranded RNA virus belonging to the family Bunyaviridae, genus Nairovirus. The virus can be transmitted mainly through direct contact with blood or tissues from infected livestock or through bites of Hyalomma ticks. CCHF is a public health problem in many regions of the world, including Africa, Middle East, southern and Eastern Europe, and Western Asia. Crimean-Congo hemorrhagic fever (CCHF) virus causes a hemorrhagic and toxic syndrome disease in humans and high mortality rates of up to 50%. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase are raised, and bleeding markers are prolonged. Infection of the endothelium has a major pathogenic role. Besides direct infection of the endothelium, indirect damage by viral factors or virus-mediated host-derived soluble factors that cause endothelial activations and dysfunction are thought to occur. In diagnosis, enzyme-linked immunoassay and real-time reverse transcriptase polymerase chain reaction are used.
Key Words: Crimean haemorrhagic fever (CCHF), Nairovirus, Ribavirin.
Review article:-
*VijayKumar Chauhan1, Dr. Rajesh K.S1, Deepak.G.Umalkar1, Lokendra Pal Singh1, Khushbu Shah1, Kuldipsinh Pagi1.
1.Department of Pharmaceutics, Parul Institute of Pharmacy, Limda, Vadodara, Gujarat-391760, India.
Abstract:-Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (MDTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self administration without water or chewing. This novel type of delivery system offers convenience for treatment-resistant population who have difficulty in swallowing unit oral dosage form, namely Tablets and Capsules. These formulations are particularly beneficial to pediatric and geriatric patients. It is estimated that 50 % of the population is affected by dysphagia which results in high incidence of non-compliance and ineffective therapy. The aim of this article is to review the ideal properties, significance, characteristics, limitation, choice of drug candidates, challenges in formulation, approaches for preparation of MDTs, Patented technologies on MDTs, Suitable drug candidates for MDTs, Marketed product of MDTs, and Evaluation tests of MDTs.
Key words: Fast disintegrating, Mouth Dissolving Tablet, Dysphagia.