DocumentsDate added
Review article:-
A B Roge*, S N Firke, S B Gaikwad, V N Gunjkar, Dr. S M Vadvalkar Pharmaceutical Chemistry Department, Nanded Pharmacy College, Shyam Nagar, Nanded,India.
Abstract:-Bioadhesion is the relatively new and emerging concept in drug delivery, Bioadhesion keeps the delivery system adhering to the mucus membrane. Transmucosal drug delivery systems show various merits over conventional drug delivery systems. Bioadhesive polymers facilitate the bioadhesion by their specific properties. In transmucosal drug delivery system, bioadhesive polymer plays major role along with active ingredients. Bioadhesive polymers that adhere to the mucin epithelial surface are effective and lead to significant improvement in drug delivery system. Improvements are also expected for other mucus-covered sites of drug administration. Bioadhesive polymers find application in the eye, nose, and vaginal cavity as well as in the GI tract, including the buccal cavity and rectum. This review focus on Bioadhesion, Important Factors of Bioadhesion, Ideal Characteristics, Classification, Description and Application of bioadhesive polymer.
Keywords:-Bioadhesion, Mucin, Rectum, Transmucosal drug delivery systems.
Original research article:-
*Veerendra K. Nanjwade1, F. V. Manvi1, Shamrez Ali. M2, Basavaraj K. Nanjwade1
1.Department of Pharmaceutics, KLE University College of Pharmacy, JN Medical College Campus, Belgaum – 590010, Karnataka, India.
2.Simpex Pharma Pvt. Ltd, Sigaadi, Kotdwara – 246149, Pauri Garhwal, Uttarakhand, India.
Abstract:-Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development.
Objective: In this study, we aimed to characterize the of Prulifloxacin-salicylic acid cocrystals by IR, DSC and PXRD in comparision with the pure drug.
Materials and Methods: Pharmaceutical cocrystals were prepared by the kneading method with aid of salicylic acid and urea as coformer. The cocrystals were subjected to various physicochemical studies and thermal methods.
Results and Discussion: The cocrystal of prulifloxacin , with salisylic acid (SA) has been shown to have higher solubility than prulifloxacin. In this study, we aimed to characterize the pure drug and the cocrystals with the salicylic acid and urea. Remarkably, two new cocrystals of prulifloxacin were discovered in this study. The study indicates that the improved aqueous solubility of the cocrystals leads to improved dissolution of Prulifloxacin. Thus, the cocrystals are a viable alternative solid form that can improve the dissolution rate and bioavailability of poorly soluble drugs.
Conclusion: Subsequently, differential scanning calorimetry was used to investigate the cocrystal formation. The formation of cocrystals was also verified using liquid-assisted grinding. The spectral patterns of prulifloxacin , salicylic acid and the complex were different.The physicochemical properties such as solubility and dissolution rate of this complex will be further investigated.
Key words: Pharmaceutical cocrystlas, Prulifloxacin, Salicylic acid, Complex.
Original research article:-
Rattan Deep Singh1, Juhi Mishra1, Anoop Kumar Dobriyal 2, *Aradhana1
1.Dept. of Biotechnology, S. Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, India.
2.Dept. of Zoology and Biotechnology, Hemwati Nandan Bahuguna Garhwal University, Pauri Campus, Pauri-Garhwal, India.
Abstract:- The present study is based on analysis of various physio-chemical properties of crude extract of lectins from selected Phaseolus vulgaris landraces. The haemagglutination and sugar inhibiting properties differ among the landraces. Sample from Dhanpoo and Darchula show maximum haemagglutinating activity (16HU). The minimum inhibitory concentration of sugar among cultivars was found in the range of 25-50 mM. The haemagglutinating activity of lectins was found to be stable upto temperature of 700C, above which there was no haemagglutinating activity. Similarly the lectin activity was found to be stable at pH range of 7-8, which means haemagglutination activity is negligible in too acidic and basic medium. The crude extract of lectins was subjected for partial purification through ammonium sulphate precipitation and SDS-PAGE analysis. The molecular weight of lectin was found to be 34kd, which is similar to commercially prepared Phytohaemagglutinin used as a standard.
Keywords:-Phytohaemagglutinin, Sugar inhibition, Haemagglutination titer.
Review article:-
*Umashankar Lakshmanadoss1, Monika Moni1, Priya Chinnachamy 2 1.Division of Hospital Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, MD1, USA.
2.All India Institute of Medical Sciences, New Delhi, India.
Abstract:-Blood transfusion is one of the common interventions done in the hospital setting on a daily basis. Complications of blood transfusions are becoming rare, thanks to the advanced technology. However, just because of the total number of transfusions, medical and paramedical persons may encounter these situations more often than thought. Complications related to blood transfusion may be divided in to acute and delayed transfusion reactions based on the time of presentations. Acute reaction ranges from allergic reactions and febrile nonhemolytic reactions which are benign to febrile hemolytic reactions which could be life threatening. In addition to these febrile reaction, development of hypoxia after transfusion is always concerning as this could be a manifestation of circulatory volume overload or Transfusion Related Lung Injury (TRALI). Differentiating TRALI from circulatory volume overload is very important as diuretics are indicated in circulatory overload and they are not useful in TRALI. Transfusion related infections are rare nowadays thanks to the advanced technology. Most common cause of blood transfusion errors are due to human errors. Transfusion is a multistep procedure and needs a constant vigil at various levels to prevent these complications. A unique barcode on each patient’s wristband is used to identify the patient’s cross-match blood samples and each unit of blood prepared for that patient. This program have been tested and implemented successfully in various institutions including the author's institution (UL). Here, we are presenting a patient who developed TRALI following blood transfusion. In this article, we also reviewed the complications of blood transfusion, ways to prevent them and their management.
Original research article:-
Tanuja Shailesh1, Dinesh Acharya U2, * Shailesh K R3
1,2.Dept. of CSE, MIT, Manipal University, Karnataka ,India.
3.Dept. of E & E, MIT, Manipal University, Karnataka , India.
Abstract:-Data mining has a wide use in the healthcare domain in areas such as diagnoses and patient management. One of the main concerns in the healthcare area is the measurement of flow of patients through hospitals and other health care facilities. For instance if the inpatient length of stay (LOS) can be predicted efficiently, the planning and management of hospital resources can be greatly enhanced. Hospital LOS of inpatients is frequently used as a proxy for measuring the consumption of hospital resources and therefore it is essential to develop accurate models for the prediction of inpatients LOS. In this paper we apply text mining techniques to pre-process the text data of electronic discharge summaries available in HTML format and apply traditional data mining techniques such as k-means clustering to analyze the textual information for classifying discharge summaries based on disease and patient’s length of stay in the hospital.
Keywords: Text mining, Discharge Summary, Regular Expression, feature extraction, Pattern recognition, length of stay, K-Means.