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Review article:- *Manorma Sharma1, Archana Sharma1 , Ashwani Kumar2
1.Department of Botany, Vedic PG Girls College, University of Rajasthan Jaipur 302004, India.
2.Department of Botany, University of Rajasthan, Jaipur 302004 ,India.
Abstract:- Tuberous plants are the vital source of medicinal drugs. Among these Asparagus racemosus is an important herb which is well known for its pharmacological applications. A lot of medicinally importance attributes have been assigned to this herb. It has been used by tribes located in distinct area of India from primeval time. Key component of this herb is saponins. Recent developments in transgenic research have opened up the possibility of the metabolic engineering of biosynthetic pathways to produce these high-value secondary metabolites. The present review is a pragmatic approach to accrue the findings on this very important herb.
Keywords:- Asparagus racemosus, Saponins, Ethnopharmacology, Disease.
Research article:- * J.V.C. Sharma1 , B.Chandra shekar1, Rahul Chakraborty1, Harika Chanda1, J.Venkateswara Rao2, H.Sanjay Kumar3.
1.MLR Institute of Pharmacy, Dundigal,Hyderabad,Andhra Pradesh, India.
2.Sultan-Ul-Uloom College of Pharmacy, Banjara Hills,Hyderabad, Andhra Pradesh, India.
3.Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India.
Abstract:-The present study was designed to evaluate the in-vitro cytotoxicity activity of aqueous extract of Glochidion zeylanicum (Gaertn.) root. In this study the extract was tested using human cancer cell lines HepG2, HT-29 and PC-3 for its effects on cell viability, growth inhibition and cell morphology. Cell viability, inhibition were determined by XTT-assay. Morphology was studied by using DAPI staining technique. The results showed decreased cell viability and increased growth inhibition in a concentration dependant manner and also altered the cell morphology after treatment with the plant extract. The data demonstrated that aqueous extract of roots of Glochidion zeylanicum (Gaertn.) has a potential cytotoxicity activity on HepG2, HT29 and PC3 cell lines but the effect was more significant on HepG2.
Keywords:- Glochidion zeylanicum (Gaertn.),HEK293, HepG2, HT29, PC3 Human cell lines, anti cancer, XTT-assay.
Review article:- * D.R.Brahma Reddy1, Chattu.V.Sesha Sai Ram 2 , T.Saravan Kumar3, Kattamuri.S.Bharat kumar 4, Vaka.Yalamanda Reddy5, Ch.Taraka Lalitha Kumari6.
1.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
2.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
3.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
4.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
5.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
6.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
Abstract:-Drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, Rapimelts have gained considerable attention as a preferred alternative to conventional tablets and capsules due to there better patient compliance. Orally disintegrating tablets offer an advantage for populations who have difficulty in swallowing. Prescription Rapimelts products initially were developed to overcome the difficulty in swallowing conventional tablets with water among pediatric, geriatric, and psychiatric patients with dysphagia. Today, Rapimeltss are widely available as over-the-counter drugs for the treatment of allergies and cold and flu. Technologies used for manufacturing of orally disintegrating tablets are either conventional technologies or patented technologies. Important ingredients that are used in the formulation of Rapimelts should allow quick release of the drug, resulting in faster dissolution. Evaluation of these tablets are done by weight variation, friability, tensile strength, wetting time, water absorption ratio, In vitro dispersion time and. dissolution test.
Keywords:- Rapimelts , Orasolv, Tensile strength, Sublimation, Disintegration, Lyophillisation , Superdisintegrants
Review article:- Dr Priyanka Singh1, Dr Bina Rani2, Dr Upma Singh3, *Dr Raaz Maheshwari4 1.Assistant Professor, School of Pharmacy, Krishna Institute of Engineering &Technology, Ghaziabad, UP, India.
2.Department of Environmental Engineering & Environmental Chemistry,PCE, Sitapura, Jaipur – 302 022, India.
3.Assistant Professor, School of Applied Science, Gautam Buddha University, Greater Noida, UP, India.
4.Head, Department of Chemistry, SBDTC, Lakshman Garh – 332 311, Rajasthan,India.
Abstract:- In recent years, great concern has been universally voiced regarding environmental pollution arising as a side effect of industrial and other human activities. In our own country, with the advent of industries, more and more toxic substances are either used as raw material or emitted during manufacturing processes in the form of dusts, fumes, vapours and gases. These pollutants ultimately dissipate in the working environment and pose occupational health hazards. Many of these chemicals are hazardous and impose chronic impact on organisms including human beings. By the very nature of their wide distribution, the halogen group of minerals, including fluorides, forms a natural part of our environment. In order to strike a balance between such an environment and general health of human population and live stock of any region, the level of fluoride concentration in potable water, food, soil and atmosphere needs to be an appropriate level. Fluorosis, though a common endemic problem of our country is more widespread and acute in Rajasthan. According to a report published on 17th November 2004 by Tribune News Service, 19 states are endemic for fluorosis viz AP (16), Assam (2), Bihar (5), Chhattisgarh (2), Delhi (7), Gujarat (18), Haryana (12), J & K (1), Jharkhand (4), Karnataka (16), Kerala (3), MP (14), MS (10), Orissa (18), Punjab (17), Rajasthan (32), TN (8), UP (7) and WB (4) of India. The number in Parenthesis in the total number of districts confirmed for fluoride endemicity. Over exploitation of groundwater in the last 20 years, is the chief reason for the spread of a dreadful disease. The conventional belief that fluoride affects only bone and tooth has been negated as the evidences on the involvement of soft tissues of the body are convincing. By employing SPANDS (Zr – alizarin red-s visual dye lake) method, fluoride ion concentration in water samples of various places in Rajasthan, were determined spectrophotometrically at 570nm. Defluoridation of contaminated water alone doesn’t bring the fluoride content to safe limit. It would be necessary to overcome the toxicity of the remaining fluorides ingested other sources. This is achieved by effecting minor changes in the diet and dietary habits of the population compatible with their social system and available resources.. Since soil fluorides usually originate from micas are associated with clay-sized minerals, heavy soils tend to have substantially higher concentrations than sandy soils. Fluoride enters the soil through weathering of rocks, precipitation and impure water, mainly from waste run-off and fertilizers. Since much of our food is ultimately derived from plants often grown in contaminated areas, fluoride in soil is an important source of intake. Anti-oxidants possessing antagonistic effect play prophylactic role in preventing fluorosis. A malady-remedy analysis of the problem of fluorosis has to be holistic in character as the disease not only affects human beings but also plants and animals. Therefore, we need to have, as far as possible, an idea of the sources of fluoride and its dispersion in the environment including land, water and air. Based on such study, an integrated approach has to be evolved to draw up a strategy for the control of this disease. In this manuscript clinical manifestations of various degrees of fluorosis and strategies concerning to mitigation of fluoride content in water, have been delineated.
Keywords : -Fluorosis; RWH; Clinical manifestations; Reverse osmosis; Defluoridation.
Research article:- 1Sood Parul, 2Pasrija Anubhuti*, 3Singh Rahul, 4Katiyar Chandrakant, 5Nanda Sanju.
1.Lecturer , Pharmacognosy , Baddi University ,H.P, India.
2.Dabur Research & Development Centre, Dabur India Limited, Plot No.22, Site IV, Sahibabad-201010, Ghaziabad (U.P.), India.
3.Dabur Research & Development Centre, Dabur India Limited, Plot No.22, Site IV, Sahibabad-201010, Ghaziabad (U.P.), India.
4.Dabur Research & Development Centre, Dabur India Limited, Plot No.22, Site IV, Sahibabad-201010, Ghaziabad (U.P.), India.
5.Reader in Pharmaceutics, Department of Pharm. Sciences, M.D.U.Rohtak-124001, India.
Abstract:- Standardized manufacturing procedures and suitable analytical tools are required to establish the necessary framework for the quality control in herbals. Among these tools, HPTLC (High Performance Thin Layer Chromatography) is one of the most widely used to establish the reference fingerprints of herbs against which raw material can be evaluated and finished product can be assayed. The present research work deals with the characterization and identification of some herbal drugs from three different regions having wide range of medicinal properties, their herbal extracts and marketed formulations by HPTLC fingerprinting. These fingerprints are unique and help to characterize and identify the drugs. It demonstrates the suitability of the fingerprints for the detection of adulterants, batch comparison of market formulations for quality evaluation and regulatory purposes .
Key words:- Fingerprinting, Herbal, HPTLC, Marker compound.