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Research article:- Dr.Pramiladevi.R. MD1 , Dr. Gooranavar. S.M. MD2, Dr. Biradar.Satish.B. MD3 , Dr. Baragundi .Mahesh.C. MD4 , Dr. Kora .S.A. MD5, Dr.Narayan.M MS. 6
1.Associate Professor in Dept. of Medicine, S.Nijalingappa Medical College Bagalkot-587102 Karnataka India.
2.Asst- Professor in Dept. of Medicine, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India.
3.Asst- Professor in Dept. of Medicine, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India.
4 Associate Professor in Dept. of Microbiology, S.Nijalingappa Medical ,College Bagalkot-587102 Karnataka India.
5.Associate Professor in Dept. of Medicine, S.Nijalingappa Medical ,College Bagalkot-587102 Karnataka India. 6.Senior Resident in Dept. of Surgery, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India.
Abstract:
Context: Dyslipidemia and hypertension are the commonest risk factors for coronary artery disease (CAD). Persons with combination of risk factors are particularly at high risk of CAD. There is also pronounced influence of blood pressure on the rate of atheroma formation in human subjects. Isolated systolic hypertension commonly seen in elderly subjects can be attributed to atherosclerosis induced stiffening of aorta and major arteries. Aim: This study was therefore carried out 1.To know abnormal lipid profile prevalence and pattern among hypertensive patients and 2.To know association between hypertension and dyslipidemia in our population. Materials and Methods: The present study was carried out on a total of 50 hypertensive patients attending our tertiary care Hospital and 50 age and sex matched healthy controls. Twelve hour fasting lipid analysis was done for Serum triglycerides(TG), total cholesterol(TC), HDL, LDL, VLDL, TC/HDL, Lp(a)&CLTI. Lipid fractions were tabulated according to NCEP/ATP III new guide lines. Statistical analysis was done by t test, Z test and Chi square test. Results and conclusions: Over all mean lipid levels of TC, LDL, Lp(a), TC/HDL >4.5, showed statistically significant association with cases compared to controls. No significant association was noticed in HDL levels between cases and controls. Mean lipid levels with respect to sex, showed abnormalities in TC, Lp(a) and TC/HDL, CLTI more in hypertensive males compared to females as well as controls. Elevation of TC and decrease in HDL was found as the severity of hypertension increased. The commonest individual lipid fraction abnormality was low HDL in 74% followed by elevated total cholesterol in 52%. Next commonest being TC/HDL >4.5 in 50%, followed by elevated Lp(a) in 36%. Commonest lipid abnormality was abnormal TC/HDL>4.5& elevated TG together in 86%. Over all prevalence of all forms of dyslipidaemia was 90%
Key Messages:1.Elevated TC, LDL, Lp(a), TC/HDL >4.5, are significantly associated with hypertension and we must consider primary and secondary prevention with life style modification and drug therapy in hypertensive patients.2.There is no significant association between HDL levels and hypertension.3.Commonest lipid abnormality is abnormal TC/HDL& elevated TG together in 86% and over all prevalence of all forms of dyslipidaemia is 90% (too high). 4.Abnormalities in lipid profile antedate the occurrence of stage I hypertension, therefore it is advisable to recommend lipid profile as screening of asymptomatic prehypertensive patients.
Key words: -Hypertension, Dyslipidaemia, HDL, LDL, VLDL, TC/HDL, Lp (a), CLTI.
Original research article:- *Ekram M. Hassan1, Mohamed S. Mahrous2 and Ruba N.Shdeed1 1Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry and Quality Control , Beirut Arab University, Riad El Solh 11072809 P.O. Box 115020Beirut, Lebanon.
2Faculty of Pharmacy, Department of Pharmaceutical Chemistry , Beirut Arab University, Riad El Solh 11072809 P.O. Box 115020,Beirut, Lebanon.
Abstract:- Two spectrophotometric methods are presented for the determination of a ternary mixture containing chlorpheniramine maleate, diclofenac sodium and paracetamol in combined dosage form without prior separation. The first method is the derivative ratio spectra zero crossing method (DRSZ) where chlorpheniramine maleate, diclofenac sodium were determined by measuring the DD1 amplitudes at 246.7nm, 290.2 nm and paracetamol was determined by measuring the DD1 , DD2 and DD3 amplitudes at 252.8nm, 246.3 nm and 254.3 nm , respectively. The second method is the double divisor ratio spectra derivative method (DDRD) where diclofenac sodium was determined by measuring the DD1 , DD2 at 311 nm and 307 nm, respectively and paracetamol was determined by measuring the DD1 , DD2 and DD3 amplitudes at 253.7nm, 247.9 nm and 253.8nm , respectively. The methods were linear over the concentration range 20-100 μgml-1 chlorpheniramine maleate, 5-40 μgml-1 diclofenac sodium and 2-18 μgml-1 paracetamol. The described methods are rapid , accurate, simple and precise and can be used for quality control of such mixture.
Key words:-Chlorpheniramine maleate, diclofenac sodium, paracetamol , ternary mixture , derivative ratio, double divisor derivative ratio.
Review article:- *S K Bais and A V Chandewar Pataldhamal Wadhwani College of Pharmacy, Yavatmal,-445001, India.
Abstract:-In order to ascertain accumulation of heavy metals, investigations were performed by using atomic absorption spectrometry. The results showed heavy metals accumulation in plant, procured from polluted sites as compared to unpolluted sites. The main purpose of the review is to document evidence for the users, collectors, and practitioners of in marketed Herbal medicine. The clinical manifestations of metal poisoning have been well characterized and documented. Heavy metal poisoning has decreased because of improved industrial hygiene and environmental controls so that the signs and symptoms of such poisoning are likely to go unrecognized. If metal poisoning is identified, the true source may be wrongly associated with environmental occupational exposures. Hence it is necessary to toxicological parameters standardization of herbal medicine marketed in India before its marketing.
Key words:-Herbal Medicines, AAS, Arsenic, cadmium, lead, Mercury.
Case Report:- C Bharath1, M.D, Shdakshari G2, M.D,DCP, Vijayanath.V3.
1.Professor, Department of Pathology, Govt. Medical College, VIMS ,Bellary – 583 104,Karnataka State, India.
2.Assistant Professor, Department of Pathology, Govt. Medical College, VIMS ,Bellary – 583 104,Karnataka State, India.
3.Associate Professor, Department of Forensic Medicine & Toxicology, S.S.Institute of Medical Sciences & Research centre,Davangere-577005,Karnataka, India.
Abstract:- Schwannoma of head and neck region are common accounting for 25%. The thyroid gland is an infrequent and rare site for the occurrence of Schwannoma. These tumors often mimic a thyroid nodule. A case of Schwannoma of thyroid gland was diagnosed on histopathological examination.
Key words :- Thyroid gland, benign tumor, Schwannoma, nonepithelial origin.
Research article:-A. G. Rajalakshmi 1, J.Unnithan2, *S. Sudha 1
1.Department of Biotechnology, Karpagam University, Coimbatore 641021, Tamil Nadu, India.
2.Department of Pulmonology, Kovai Respiratory Care and Research Centre, Coimbatore 641002, Tamil Nadu, India.
Abstract:-The occurrence of both obesity and asthma has increased among people over the last several decades. Former data on the association between obesity and asthma has been inconsistent. This study aimed to examine the association of obesity with total IgE levels in south Indian asthma subjects. The serum IgE level was examined in 75 asthma patients and their severities of asthma were determined by pulmonary function tests. Serum IgE level was compared with the severity of asthma and Body Mass Index. Total serum IgE levels significantly increased in obese and asthma groups when compared to control subjects (p<0.005). The data indicated a significant positive correlation between IgE levels and body mass index (BMI) in asthmatic patients (mild P<0.009, moderate P<0.021 and severe asthma P<0.010). The present study suggests that the serum IgE level may reproduce the severity of bronchial asthma. The evidence for the relationship between obesity and asthma is not conclusive however the study finds a positive association between obesity and asthma among south Indian asthmatic subjects.
Key words:-Asthma, BMI, total IgE, obesity, south India.