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Research article:- *Gauri Bhawna1, Nagpal Lovekesh1 , Singh Shailendra K2,
1.Division of Pharmaceutics, Department of Pharmaceutical sciences, Lord Shiva College of Pharmacy, Sirsa-125055, Affiliated to Pt. B. D. Sharma University of Health Sciences, Rohtak-124001, (Haryana), India.
2.Division of Drug Delivery and Research, Department of Pharmaceutical Sciences, Guru Jambeshwar University of Science and Technology, Hisar-125001, (Haryana)-India.
Abstract:- Tinidazole is used in treatment of amoebiasis and other protozoal infection in doses of 2.0 gm/day (60mg/kg) for 3 successive days. In the present paper, controlled release formulation of tinidazole was developed with an objective to achieve colon specific drug delivery system with reduced frequency of dosing, to minimize gastric side effects and thus to increase patient’s compliance. Matrix system of tinidazole were prepared by using swellable pH dependent polymer like Hydroxypropylmethylcellulose (HPMC-K4M) and guar gum and methacrylic acid polymers like Eudragit FS 30D. Prepared tablets were compression coated in order to overcome variability in gastric emptying time and delay in release, to reduce the gastric side effects and to provide prolonged localized action in colon. The coated formulations were evaluated for dissolution rates under stomach and simulated intestinal conditions in presence of rat cecal conent medium. In-vivo gamma scintigraphy study was also performed on (F3) formulation in healthy human volunteers using Tc-99m as a tracer medium. In-vitro drug release studies and In-vivo gamma-scintigraphic studies using Tc-99m as a tracer indicated that greater portion of tinidazole was released in the large intestine and drug level was maintained in blood for 20h. From the results of the study, it appears that the proposed single coated tinidazole tablet per day could be used in place of 3-4 doses of 500mg tinidazole conventional tablets with better control of drug release for targeted drug delivery. In addition developed colon-specific drug delivery system was relatively inexpensive and easy to manufacture using conventional coating pharmaceutical technique.
Keywords: Colon-specific; Eudragit FS30D polymer; Guar gum; Hydroxypropylmethylcellulose K4M; Tinidazole.