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Research article:- *Gauri Bhawna1, Nagpal Lovekesh1 , Singh Shailendra K2,
1.Division of Pharmaceutics, Department of Pharmaceutical sciences, Lord Shiva College of Pharmacy, Sirsa-125055, Affiliated to Pt. B. D. Sharma University of Health Sciences, Rohtak-124001, (Haryana), India.
2.Division of Drug Delivery and Research, Department of Pharmaceutical Sciences, Guru Jambeshwar University of Science and Technology, Hisar-125001, (Haryana)-India.
Abstract:- Tinidazole is used in treatment of amoebiasis and other protozoal infection in doses of 2.0 gm/day (60mg/kg) for 3 successive days. In the present paper, controlled release formulation of tinidazole was developed with an objective to achieve colon specific drug delivery system with reduced frequency of dosing, to minimize gastric side effects and thus to increase patient’s compliance. Matrix system of tinidazole were prepared by using swellable pH dependent polymer like Hydroxypropylmethylcellulose (HPMC-K4M) and guar gum and methacrylic acid polymers like Eudragit FS 30D. Prepared tablets were compression coated in order to overcome variability in gastric emptying time and delay in release, to reduce the gastric side effects and to provide prolonged localized action in colon. The coated formulations were evaluated for dissolution rates under stomach and simulated intestinal conditions in presence of rat cecal conent medium. In-vivo gamma scintigraphy study was also performed on (F3) formulation in healthy human volunteers using Tc-99m as a tracer medium. In-vitro drug release studies and In-vivo gamma-scintigraphic studies using Tc-99m as a tracer indicated that greater portion of tinidazole was released in the large intestine and drug level was maintained in blood for 20h. From the results of the study, it appears that the proposed single coated tinidazole tablet per day could be used in place of 3-4 doses of 500mg tinidazole conventional tablets with better control of drug release for targeted drug delivery. In addition developed colon-specific drug delivery system was relatively inexpensive and easy to manufacture using conventional coating pharmaceutical technique.
Keywords: Colon-specific; Eudragit FS30D polymer; Guar gum; Hydroxypropylmethylcellulose K4M; Tinidazole.
Original research article:-Shep Dhaneshwar1, Ojha Ashwini 2, Patel Sweta3, Nivsarkar Manish4, *Jaiswal Vijaya5 and Padh Harish6
1.Sr. Manager, Medical Services, Troikaa Pharmaceuticals Ltd., Ahmedabad, India.
2.Scientist A, Department of Bio-analytical, B.V. Patel PERD Centre, Ahmedabad, India 3.Research Assistant, Department of Biostatistics, B.V. Patel PERD Centre, Ahmedabad,India. 4.Joint Director, Department of Pharmacology and Toxicology, B.V. Patel PERD Centre, Ahmedabad, India.
5.Vice-President, Medical Services, Troikaa Pharmaceuticals Ltd, Ahmedabad, India.
6.Vice chancellor, Sardar Patel University, Vallabh Vidyanagar, India.
Abstract:-The prodrug fenofibrate, a synthetic phenoxy-isobutyric acid derivative, is rapidly hydrolyzed in vivo to form fenofibric acid, which alters plasma lipid levels by activating the peroxisome proliferator-activated receptor alpha. The aim of this study was to compare the bioavailability and tolerability of 2 oral formulations of fenofibrate 145 mg. The study was designed as a single-dose, randomized, single-label, 2-period crossover study in healthy Indian adult volunteers. Subjects received 1 tablet of each fenofibrate 145 mg formulation. Study drugs were administered with 240 mL of water after standardized meal on each of 2 treatment days separated by a 2-week washout period. After study drug administration, serial blood samples were collected over a period of 96 hours. Plasma was analyzed for fenofibric acid concentration using a validated high-performance liquid chromatography method. Pharmacokinetic (PK) parameters Cmax, Tmax, t1/2, AUC0-t, AUC 0-∞, and kel, were determined for the 2 fenofibrate formulations. The formulations were to be considered bioequivalent if the log-transformed ratios of Cmax, AUC0-t, and AUC0-∞ were within the predetermined bioequivalence range of 80% to 125%. A total of 18 subjects were enrolled. No significant differences were found based on analysis of variance, with mean values and 90% confidence intervals of test/reference ratios for these parameters as follows: Cmax, 6.40 versus 7.12 μg/mL (81.71 – 103.05); AUC0-t, 139.57 versus 153.50 μg.hr/mL (85.56 – 102.02); and AUC0-∞, 147.49 versus 161.25 μg.hr/mL (83.44 – 105.87). In these healthy adult Indian volunteers, results from the PK analysis suggested that the test and reference formulations of fenofibrate 145 mg tablets were bioequivalent. Both the formulations were well tolerated.
Key words :- Bioequivalence, Fenofibrate, Pharmacokinetics.
Research article:-*Tanuja S1, Dr. U. Dinesh Acharya2, *Shailesh K R3
1.Assistant Professor, Department of Computer Science Engineering, MIT, Manipal University, India.
2.Professor and Head, Department of Computer Science Engineering, MIT, Manipal University, India.
3.Assistant Professor (Sr.), Department of Electrical& Electronics,MIT, Manipal University,India. Abstract:-In this paper we present the performance analysis of different data mining techniques to predict the inpatient hospital length of stay in a super specialty hospital. Data set used for the analysis is real time data taken from super specialty hospital. Pre-processed data set is generated from the electronic discharge summaries obtained from the hospital. This data set consists of 401 records with 16 parameters. In this paper we have investigated four data mining techniques: Multilayer back propagation NN, Naive Bayes Classifier, K-NN method, J48 class of C4.5 decision tree. We found from the analysis that Neural Network has achieved better performance compared to the other three techniques.
Key words:- Data Mining, Text Mining, Back propagation, Neural Networks, K-NN, J48, Naive Bayes , Scoring System, missing data replacement.
Research article:- *Dr. Uma Maheswara Rao V, M.Pharm, Ph.D1, Dr. Gaviraj E.N, M.Pharm, Ph.D, . 2 Veeresham C, M.Pharm, Ph.D,PDF,3
1.School of Pharmacy, Nalla Narasimha Reddy Educartion Society’s Group of Institutions, Korremula 'X' Road, Ghatke-sar (Mandal), Ranga Reddy (Dist), A.P, India- 500 088,India.
2.University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India. 3.University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India
Abstract:- The production of hypericins, which are antidepressant, anticancer and anti-HIV constituents of Hypericum perforartum (St. John’s Wort) by in vitro techniques is increasingly considered as an alternate source. Shoot cultures, at different growth phases, were therefore treated with a variety of precursors and organic compounds to stimulate the biosynthesis of hypericins. Since sodium acetate and emodin at 10 mg/l stimulated the accumulation of hypericins at a mid exponential growth phase, dose optimization of these precursors was carried out at the concentrations of 5, 10, 25 and 50 mg/l. A dose-dependent improvement in the yield was seen with sodium acetate. At 50 mg/l, the production of pseudohypericin (236.4 mg/l) increased by 2.4-folds while it was 2.2-folds high for hypericin (17.16 mg/l). However, emodin at 25 mg/l produced the greatest response. The accumulation of pseudohypericin increased by 3.2-fold to 309.7 mg/l and hypericin accumulated up to 25.8 mg/l, which was 2.5-folds more than that of the control. Prominent enhancement in the yields was achieved when sodium acetate and emodin were feeded simultaneously. The accumulation of pseudohypericin and hypericin was elevated, respectively, by 4.5- and 3.7-folds. Among the organic compounds, succinic acid (5 mM) and malic acid (10 mM) stimulated the production of hypericins at a mid exponential growth phase although the effect was moderate. Our study indicated a key role of sodium acetate and emodin in enhancing the accumulation of hypericins in shoot cultures of H.perforatum.
Key words :- Hypericum perforatum, hypericins, organic compounds, precursors, shoot cultures.
Research article:- * K Apparao Rayavarapu, DSVGK Kaladhar and Santosh Kumar S Department of Biochemistry / Bioinformatics, GITAM University, Visakhapatnam,India.
Abstract:- Study of antibacterial and antifungal activity of plant extract of Lawsonia inermis (henna) on Aeromonas, Pseudomonas, Vibrio of Gram negative bacteria and candida albicans of fungi has been conducted. Hexane, Chloroform and Methanol has been taken as solvents. Methanolic plant extract has shown good activity against aqua bacteria and fungi, compared with Hexane and Chloroform extracts. Lawsonia inermis has shown good activity against Aeromonas and, Vibrio.
Key words:- Henna, Lawsonia Inermis, Antibacterial, Antifungal, Aqua pathogens.