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Original research article:- N. G. Raghavendra Rao*, M. Subhan
PG. Department of Pharmaceutics, Luqman College of Pharmacy Gulbarga- 585 102. Karnataka, India.
Abstract:- An attempt has been made for the development of fast dissolving tablets of the nimodipine by solid dispersion methods, using different concentrations of croscarmellose sodium as super disintegrating agent and study the effect of various carriers on solid dispersion technique. Nimodipine is used in the treatment of various cardiovascular disorders such as angina pectoris, cardiac arrhythmia and hypertension. The major problem of this drug is very low solubility in biological fluids and poor bioavailability after oral administration. The prepared tablets were evaluated for post-compressional parameters like hardness, friability, drug content, disintegrating time, wetting time, In-vitro dissolution studies and stability studies. The prepared tablets were characterized by DSC and FTIR Studies. No chemical interaction between drug and excipients was confirmed by DSC and IR studies. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The formulations prepared with mannitol solid dispersion were showed disintegration time between the ranges of 15.12 - 21.92 sec and drug release showed between the ranges of 09 - 11 min. However the formulations prepared with PEG‐6000 and PVP solid dispersions did not disintegrate in specified limit of time for fast dissolving tablet. Among all formulations SM4 prepared with mannitol as carrier showed 99.63 % drug release within 9 minutes. The results concluded that fast dissolving tablets of poorly soluble drug, Nimodipine showing enhanced dissolution will lead to improved bioavailability, improved effectiveness and hence better patient compliance. Finally it is concluded that effect of mannitol as a carrier on solid dispersion technique is excellent and shows best result.
Keywords:- Fast dissolving tablets, Nimodipine, croscarmellose sodium, Solid dispersion.
Research article:- * Panwar Mangal Singh1, Goyal Anju2
1.Mandsaur Institute of Pharmacy, Mandsaur, M.P -458001, India.
2.B.N. Girls College of Pharmacy, Udaipur , Rajashthan , India.
Abstract:- A simple, Precise, accurate, fast and economical methods have been developed for the quantitative estimation of Tenoxicam from tablet formulation using Erichrom black T. Tenoxicam forms a Blue colored chromogen with the reagent, which shows absorbance maxima at 421.5 nm and linearity in the concentration range of 5-25 µg/ml of drug. The results of analysis for the methods were validated statistically and by recovery studies.
Key Words:- Erichrom black T, Tenoxicam.
Original research article:- Abdul Bari Mohd1, P.Swathimutyam1, A.Padmanabha Rao1, *Nalini Shastri2, and Prakash V Diwan1
1.Department of Pharmaceutics, School of Pharmacy (formerly Lalitha College of Pharmacy),Venkatapur, Ghatkesar,Hyderabad, AP ,India.
2.Department of Pharmaceutics, NIPER, Hyderabad, AP , India.
Abstract:-The present study was designed to develop a newer method for nano emulsions with glibenclamide as a anti diabetic drug. The method was carried out using (Gemini5µ C18 110A 100×4.60mm 5micron) with mobile phase comprised of methanol: 0.2M phosphate buffer PH 7.0 in the ratio (70:30). The flow rate at 1.0 ml/min and effluent was detected at 228nm. The retention time of glibenclamide was observed at 3.2 minutes. The method was validated for specificity, accuracy, precision, linearity, and limit of detection, limit of quantification, robustness and solubility. LOD and LOQ were 200 and 800 ng/ml respectively. The calibration curve was linear in the concentration range of 1- 2 µg/ml with coefficient correlation of 0.999. The percentage recovery for the glibenclamide was 99.8% and % RSD was less than 1 %. There are scanty reports with relation to determination of gliblencamide in nanoemulsion formulation. The proposed method was used for quantitative determination of glibenclamide in nano emulsion and is authenticated using various parameters.
Key words:- Glibenclamide, Anti diabetic drug, methanol, phosphate buffer, HPLC, Validation.
Review article:- *Dr. Prashanth H.V1, Dr. . Kavyashree A N 2, Dr. Saldanha Dominic R. M 3
1.MBBS., M.D. Associate Professor Department of Microbiology, Sri Siddhartha Medical College, Tumkur. Karnataka, India.
2.MBBS., M.D. Assistant Professor, Department of Anatomy, Sri Siddhartha Medical College, Tumkur. Karnataka, India.
3.MBBS., M.D. Associate Professor Department of Microbiology, Kasturba Medical College, Mangalore. Karnataka, India.
Abstract:-Hospital waste generation has become a prime concern due to multidimensional ramifications as a risk factor to the health of patients, hospital staff and extending beyond the boundaries of the medical establishment to the general population. Hospital waste management has been brought into focus in India recently, particularly with the notification of Bio Medical Waste (BMW) (Management and handling) Rules 1998. The following are the elements of a comprehensive waste management system. Handling, segregation, mutilation, disinfection, storage, transportation and final disposal. Lack of concern, motivation, awareness and cost factor are some problems faced in the proper waste management. Appropriate education, training and the commitment of healthcare staff, management and healthcare managers within effective policy and legislative framework is required for effective hospital waste management.
Key Words:- Biomedical Waste (Management and Handling) Rules, Biomedical waste management.
Original research article:- *Kundan Singh Bora1 (M. Pharm.) and Anupam Sharma2 (Ph.D., M.D.)
1.NIMS University Rajasthan, Shobha Nagar, Jaipur-303 121, India.
2.University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160 014, India.
Abstract:- Medicago sativa Linn. (family: Leguminosae) has a long tradition of use as Ayurvedic and Homoeopathic medicine in variety of central nervous system (CNS) disorders. Traditionally, M. sativa is used to improve the memory, to cure kidney pain, cough, as a rejuvenator, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and in CNS disorders. Despite a long tradition of use, no systematic phytochemical and pharmacological work has been carried out on this potential plant. The present study has been designed to evaluate the anxiolytic activity of different fractions of bioactive methanol extract of the aerial parts of M. sativa using widely accepted elevated plus-maze model of anxiety in mice. An attempt has been made to isolate the bioactive fraction by resorting to bioactivity directed fractionation and column chromatographic technique. Sub-fraction F4 of bioactive ethyl acetate fraction which was derived from the methanol extract of the plant showed significant anxiolytic activity at a dose of 20 mg/kg, p.o., as compared to the standard drug, diazepam (2 mg/kg p.o.). TLC profile of this sub-fraction comprises of four spots indicating presence of flavonoid components. The study validates the traditional use of M. sativa for the treatment of CNS disorders like anxiety.
Key Words:- Anti-anxiety, Ethyl acetate fraction, Flavonoids, Medicago sativa.