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Review article:- *Goyal Parveen Kumar1(M.Pharm.,PGDPL), Sharma Shekhar2 (M.Pharm, DIPL), Kumar Rishi3 (M.Pharm.)
1.Department of Pharmacology, Hindu College of Pharmacy, Sonepat-131001, Haryana ,India.
2.Department of Pharmaceutical Biotechnology, Hindu College of Pharmacy, Sonepat-131001, Haryana ,India.
3.Department of Pharmacognosy, IIMT College of Pharmacy, Greater Noida, India-201306.
Abstract:- The prescription drugs are generally either branded/innovator or generic drugs. The process of drug discovery and development, including FDA approval and clinical trials, is quite expensive and consumes many years to bring any innovator drug in market thereby branded drugs are of fairly high cost which are beyond the reach of general public. To achieve the goal of health care system, promotion and preservation of health at the level of general public, only branded drugs are not sufficient hence generic drugs, that contain same active ingredients, as of innovator drug, comparable in terms of strength, quality and therapeutic effectiveness, sold at low cost, are required. The Hatch Waxman Act support generic companies, procure generic drugs to common people at reasonable price, and also maintained the balance between innovator and generics. This manuscript describes how Hatch-Waxman Act provide the generics at lower cost in the reach of general public as well as rejuvenate the drying pipeline of patented drugs.
Keywords: Hatch Waxman, Generic, Innovator, Exclusivity, ANDA, Paragraph IV Certification.
*Soumendra Sahoo 1, Rashmirekha Sahoo 2, , and Padma Lochan. Nayak 3 .
1.Associate Professor, Ophthalmology, Melaka Manipal Medical College,Malaysia.
2Senior Lecturer, Faculty of Science & Technology, Nilai University College, Nilai, Malaysia. 3.P.L.Nayak,Chairman PL Nayak Research Foundation & Institute of Nanobiotechnology, Neelachal Bhavan, Bidyadharpur, Cuttack- 753004, Odisha, India.
Abstract:- Polysaccharide based biomaterials are an emerging class in several biomedical fields such as tissue regeneration, particularly for cartilage, drug delivery devices and gel entrapment systems for the immobilization of cells. Important properties of the polysaccharides include controllable biological activity, biodegradability, and their ability to form hydrogels. Most of the polysaccharides used derived from natural sources; particularly, tamarind seed polysaccharide (TSP), alginate and chitin, three polysaccharides which have an extensive history of use in medicine, pharmacy and basic sciences, and can be easily extracted from tamarind kernel powder, marine plants (algae kelp) and crab shells, respectively. The recent rediscovery of poly-saccharide based materials is also attributable to new synthetic routes for their chemical modification, with the aim of promoting new biological activities and/or to modify the final properties of the biomaterials for specific purposes. These synthetic strategies also involve the combination of polysaccharides with other polymers.
Key words:- Polysaccharides; TSP, Ocular, Mucoadhesive, Drug Delivery.
Original research article:- 1 Dr. Chanchal Garg, 2 Prof. S. H. Ansari, 2 Prof. S. A. Khan, 3Dr. Munish Garg.
1.Vaish Institute of Pharmaceutical Education and Research, Rohtak-124001, Haryana, India 2.Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India.
3.Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India.
Abstract:- Present work is based on screening of Foeniculum vulgare Mill. Fruit extracts in high fat diet fed albino rats for their possible role in obesity and associated cardiovascular disorders. Three fractions prepared by successive solvent technique from methanol extract of Foeniculum vulgare Mill. fruits were administered at a dose of 300 mg/body weight by oral gavage and volatile oil obtained by hydrodistillation at a dose of 0.2 ml/body weight intraperitoneally once daily along with high fat diet to the female albino rats for six weeks (0-42 days). Normal control and high fat diet fed control groups were maintained simultaneously. Body weight of the experimental animals was estimated every week while lipid parameters and fat pad weights were estimated after 42 days after sacrificing the animals by euthanasia. Phytochemical studies were carried out of the above mentioned extracts. Results revealed that body weight and fat pad weights were reduced in drug fed animals in a variable pattern. Cholesterol and triglycerides levels, which were disturbed in high fat diet fed animals, improved in a significant manner. Maximum activity was observed with methanol fraction of the drug which contained maximum amount of phenolic (48.37 mg/g) and flavonoidal contents (21.44 mg/g). Based on the scientific reports, that antioxidant compounds play a vital role in the management and control of obesity via improvement in natural antioxidant defense and lipid metabolism, it is predicted that the observed activity may be due to this or more of these mechanisms. In conclusion, Foeniculum vulgare, a well known herb in Indian system of medicines has demonstrated to be effective in obesity and associated cardiovascular disorders.
Key words:- Foeniculum vulgare, obesity, cardiovascular disorders, hyperlipidemia.
Research article:- * Panwar Mangal Singh1, Goyal Anju2
1.Mandsaur Institute of Pharmacy, Mandsaur, M.P -458001, India.
2.B.N. Girls College of Pharmacy, Udaipur , Rajashthan , India.
Abstract:- A simple, Precise, accurate, fast and economical methods have been developed for the quantitative estimation of Tenoxicam from tablet formulation using Erichrom black T. Tenoxicam forms a Blue colored chromogen with the reagent, which shows absorbance maxima at 421.5 nm and linearity in the concentration range of 5-25 µg/ml of drug. The results of analysis for the methods were validated statistically and by recovery studies.
Key Words:- Erichrom black T, Tenoxicam.
Original research article:- Dr. Goornavar. S.M. MD1 , Dr.Pramiladevi.R. MD2, Dr. Biradar.Satish.B. MD3 , Dr. Malaji Sangamesh MD 4 ,Dr. Kora .S.A. MD5, Dr.Narayan.M MS. 6
1.Asst- Professor , Dept. of Medicine, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India.
2.Associate Professor, Dept. of Medicine, S.Nijalingappa Medical College Bagalkot-587102 Karnataka India.
3.Asst- Professor , Dept. of Medicine, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India.
4.Asst- Professor , Dept. of Microbiology, S.Nijalingappa Medical ,College Bagalkot-587102 Karnataka India .
5.Associate Professor , Dept. of Medicine, S.Nijalingappa Medical ,College Bagalkot-587102 Karnataka India.
6.Senior Resident , Dept. of Surgery, S.Nijalingappa Medical College ,Bagalkot-587102 Karnataka India.
Abstract:- Context: Myocardial infarction is being recognized in younger age group in recent years. Myocardial infarction in the young adult may differ from that in the elderly by virtue of its greater incidence of risk factors and atherosclerotic etiology, the heavy preponderance of male patients and better prognosis. 6% of all acute myocardial infarction and perhaps 4 times the percentage of patients with this diagnosis younger than 40 years do not have coronary atherosclerotic demonstrated by coronary angiography. They have relatively few coronary risk factors often have a history of cigarette smoking. Aim: This study was therefore carried out 1. To study the etiological profile of acute Ml in young (at or below the age of 40 years) and 2. To study the Electrocardiographic, Echocardiographic, Angiographic Correlation in patients with acute Ml in young (at or below the age of 40 years). Materials and Methods: This study was carried out at the ICCU SNMC & HSK hospital and Research Centre Bagalkot during the period from 1st 2008 to 1st 2009. Results and Conclusions: There were 350 patients of acute myocardial infarction. There were 38 patients below the age of 40 years forming 10.8% of all acute Ml’s. There were 36 males (94.7%) and 2 female (5.3%). There was no mortality seen. Coronary atherosclerosis (73%) was the most common etiology observed in 22 patients out of 30 patients. Normal coronaries (26.6%) were seen in 8 patients out of 30 patients. Smoking was the major modifiable risk factor seen in both the groups, followed by dyslipidemia hypertension. Coronary angiographic analysis revealed SVD in (68%), DVD (22.5%) and TVD (9%). Proximal LAD was the most common site involved (68.7%). In the Normal Coronaries group, the coronary risk factors included smoking (62.5%), dyslipidemia (37.5%), hypertension (25%) and diabetes (12.5%) and family history of CAD (37.5%).
Key Words:- Hypertension, Dyslipidemia, Myocardial Infarcation, Angiography, Single vessel disease, Double vessel disease, Triple vessel disease.