DocumentsDate added
Review article:- *Huma Noor1, P. K. Sharma1, V. K. Garg, A. K. Singh1, S. C. Mondal1
1.Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:- Hypoglycemia, a condition characterized by low blood sugar, is the most feared complication and a fact of life for those patients which are suffering from diabetes mellitus. Hypoglycemia may occur due to a variety of circumstances such as decrease calorie intake due to illness or hospital routine but usually it is iatrogenic. It is mainly responsible for recurrent morbidities in most of the diabetic patients and act as a barrier to maintain euglycemia for the lifetime. Typically it is the result of absolute or relative insulin excess as well as compromised glucose counterregulation in diabetes which provides the ground for long term morbidities like hypoglycemia unawareness; hypoglycemia associated autonomic failure (HAAF), counterregulatory hormonal deficiencies and in rare cases permanent impairment of cognitive functions. The frequency of hypoglycemic episodes further increase when these clinical syndromes segregate together and a vicious cycle of hypoglycemia start. Hypoglycemia may develop in both type of diabetes mellitus but patients having type 2 diabetes are at low risk in comparison to those suffering from type 1 diabetes. Some counterregulatory factors which are important for prevention of hypoglycemia are glucagon, epinephrine, cortisol, growth hormone. It has been observed that glucose counterregulatory mechanism generally remains intact in patients having type 2 diabetes, although it can be more dangerous because they are generally older and may have co morbidities. In this review article, we focus on frequencies of episodes, clinical manifestations, possible pathophysiological mechanisms related with hypoglycemia and also discuss about hypoglycemia associated risk factors, treatment and preventive strategies.
Keywords:- Hypoglycemia, Iatrogenic, Euglycemia, Glucose counterregulation, Hypoglycemia unawareness, Hypoglycemia associated autonomic failure.
Original research article:- 1N. Rathankar*, 2Kuldeep. D. Raju, , and 3H. G. Nagendra
1.Asst. Professor, Department of Bioinformatics, School of Bioengineering, SRM University, Kattankulathur, Tamilnadu, India.
2.Associate clinical data coordinator, Quintiles, Bangalore 560 001,India.
3.Professor and Head, Department of Biotechnology, Sir M. Visvesvaraya Institute of Technology, Near Hunasamaranahalli, Via Yelahanka, Bangalore 560 001,India.
Abstract:- Low Complexity regions (LCRs) in proteins are sequences containing regular repeats, cryptic repeats and single amino acid repetitions, recognized by their compositional bias , Some of these regions are highly conserved between species in both composition and sequence. These low complexity sequences are simple sequences and contain sequence segments that are entropically low. Some of these sequences do not contain a structurally homolog and are considered as information less. The SEG program originally designed by Wootton and Federhen (1993) was the first program to predict these LCRs in protein sequences. For nearly a decade, this program was used by various database search tools such as NCBI-Blastp , megablast , etc to avoid spurious hits during sequence searches by masking the low complexity regions and it is really unfortunate to note that, such fragments did not receive wide attention for a long time despite its crucial role in diseases . In this paper, an attempt to mark the importance of LCRs in drug targets related to cancer has been catalogued by us. Key Words:-Low complexity regions, SEG, cancer targets, simple sequences, polyglutamine runs.
Review article:- *Gunjan Mahendru1, P. K. Sharma1, V. K. Garg1, A. K. Singh1, S. C. Mondal
1. Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Bypass, NH-58, Meerut-250005, Uttar Pradesh, India.
Abstract:- Dengue has become a major health problem in India. It is mainly transmitted to humans by Aedes aegypti mosquito, which constitutes the etiological agents of the disease. So, for treating this disease goat milk and milk products are mostly preferred. Selenium (Se) is the main component of goat milk. Deficiency of Selenium and decrease in platelet count are the main complications of dengue fever. Goat milk as well as milk products are richest source of Selenium (Se) as comparison to cow and sheep milk. Goat milk also found to help with the digestive and metabolic utilization of various minerals.
Keywords:-Dengue fever, Goat Milk, Milk Products, Selenium, Platelet Count.
Original research article:- *Pradhan Kishanta Kumar1, Mishra Uma Shankar1, Pattnaik Subasini2, Panigrahi Ghanshyam1, Pasa Gourishyam1, Sahu Kanhu Charana1.
1.Department of Pharmaceutical Analysis and Quality Assurance, Royal college of Pharmacy and Health Sciences, Andhapasara Road, Berhampur, Odisha, India.
2.Department of Zoology, Berhampur University, Bhanja Bihar, Berhampur, India.
Abstract:- A simple method for the estimation for the estimation of Valsartan in bulk and pharmaceutical dosage forms has been developed. Methanol was chosen as the solvent system.The λmax was found to be 249nm and all absorbance values were carried out at 249nm.The responses were linear in the range of 5-100µg/ml.The regression equation of the calibration graph and correlation coefficient were found to be y = 0.028x - 0.001 and 0.999 respectively. The %RSD values for both intraday and interday precision were less than 1%. The recovery of the drug from the sample was ranged between 97.77% and 101.4%. The proposed method was validated for accuracy, precision, robustness, ruggedness,LOD and LOQ.Commercial tablets containing 40mg and 80mg of valsartan were analysed by the proposed method and the results were well within the claimed limits.Furthermore stability studies of Valsartan were carried out under acidic, alkaline, hydrolytic, thermolytic, oxidation, photolytic and UV degradation conitions as per SIAM (Stability Indicating Assay Methods).
Key Words:- Analytical method validation, Beer’s law, Forced degradation, UV- spectrophotometry, Valsartan.
*Soumendra Sahoo 1, Rashmirekha Sahoo 2, , and Padma Lochan. Nayak 3 .
1.Associate Professor, Ophthalmology, Melaka Manipal Medical College,Malaysia.
2Senior Lecturer, Faculty of Science & Technology, Nilai University College, Nilai, Malaysia. 3.P.L.Nayak,Chairman PL Nayak Research Foundation & Institute of Nanobiotechnology, Neelachal Bhavan, Bidyadharpur, Cuttack- 753004, Odisha, India.
Abstract:- Polysaccharide based biomaterials are an emerging class in several biomedical fields such as tissue regeneration, particularly for cartilage, drug delivery devices and gel entrapment systems for the immobilization of cells. Important properties of the polysaccharides include controllable biological activity, biodegradability, and their ability to form hydrogels. Most of the polysaccharides used derived from natural sources; particularly, tamarind seed polysaccharide (TSP), alginate and chitin, three polysaccharides which have an extensive history of use in medicine, pharmacy and basic sciences, and can be easily extracted from tamarind kernel powder, marine plants (algae kelp) and crab shells, respectively. The recent rediscovery of poly-saccharide based materials is also attributable to new synthetic routes for their chemical modification, with the aim of promoting new biological activities and/or to modify the final properties of the biomaterials for specific purposes. These synthetic strategies also involve the combination of polysaccharides with other polymers.
Key words:- Polysaccharides; TSP, Ocular, Mucoadhesive, Drug Delivery.