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Original research article:- * Geetha RL 1, Manjunath BK 2, Vijayanath.V 3
1.Specialist(Dept of Pathology), No 12, 1 R Block, Rajajinagar, ESIC Model Hospital, Bangalore-10,India.
2.IMO,ESIC Model Hospital, 263/N, 6th c main,RPC layout, Bangalore, India.
3.Associate Professor, Department of Forensic Medicine & Toxicology, S.S.Institute of Medical Sciences & Research centre, Davangere-577005, Karnataka, India.
Abstract:- The distribution of ABO and Rh-D blood groups was studied among 26,288 subjects. They included blood donors, transfusion recipients and patients attending Employees State Insurance Corporation(ESIC) Model Hospital for medical interventions. The most common blood group was found to be group O [10,645, (40.5%)] followed by group B [7734(29.4%)],group A [6243,(23.7%)]and group AB [1,666(6.3%)]. The prevalence of Rh-D positivity and negativity was [24955 (94.9%)] and 1333 (5.01%) respectively.
Key Words:- ABO, blood group, Rh typing.
Original research article:- 1N. Rathankar*, 2Kuldeep. D. Raju, , and 3H. G. Nagendra
1.Asst. Professor, Department of Bioinformatics, School of Bioengineering, SRM University, Kattankulathur, Tamilnadu, India.
2.Associate clinical data coordinator, Quintiles, Bangalore 560 001,India.
3.Professor and Head, Department of Biotechnology, Sir M. Visvesvaraya Institute of Technology, Near Hunasamaranahalli, Via Yelahanka, Bangalore 560 001,India.
Abstract:- Low Complexity regions (LCRs) in proteins are sequences containing regular repeats, cryptic repeats and single amino acid repetitions, recognized by their compositional bias , Some of these regions are highly conserved between species in both composition and sequence. These low complexity sequences are simple sequences and contain sequence segments that are entropically low. Some of these sequences do not contain a structurally homolog and are considered as information less. The SEG program originally designed by Wootton and Federhen (1993) was the first program to predict these LCRs in protein sequences. For nearly a decade, this program was used by various database search tools such as NCBI-Blastp , megablast , etc to avoid spurious hits during sequence searches by masking the low complexity regions and it is really unfortunate to note that, such fragments did not receive wide attention for a long time despite its crucial role in diseases . In this paper, an attempt to mark the importance of LCRs in drug targets related to cancer has been catalogued by us. Key Words:-Low complexity regions, SEG, cancer targets, simple sequences, polyglutamine runs.
Original research article:-* Kavita G.U1, Shashikala P2, Manjula. A 3, Vijayanath.V4 , Anitha.M.R5
1.Associate Professor, Department of Pathology,S.S.Institute of Medical Sciences & Research Centre ,Davangere, Karnataka,India.
2.Professor and Head, Department of Pathology, S.S.Institute of Medical Sciences & Research Centre, Davangere, Karnataka,India.
3.Assistant Professor, Department of Pathology,S.S.Institute of Medical Sciences & Research Centre ,Davangere, Karnataka,India.
4.Associate Professor,Department of Forensic Medicine & Toxicology,S.S.Institute of Medical Sciences & Research Centre,Davangere, Karnataka,India.
5.Assistant Professor,Department of Anatomy, S.S.Institute of Medical Sciences & Research Centre,Davangere, Karnataka,India.
Abstract:- Anal tumors are rare and are 20-30 times less common than colonic cancers. Tumors of the anus occur throughout the world but are particularly common in Brazil and India. The present study was undertaken to know the histomorphological patterns and incidence of anal cancers in and around Davangere, a district in central Karnataka. Anal cancers constituted 0.17% of the total specimen received for histopathology. Females (72.22%) were more commonly affected than males(27.77%). Squamous cell carcinoma was the commonest histomorphologic type of malignancy.(50%).Since symptoms of anal cancer are mostly attributed to benign conditions by most patients as well as doctors, proper identification, diagnosis and typing of the anal cancers is necessary for appropriate treatment of the same.
Key Words:- Carcinoma, cancer.