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Original research article:- Abdul Bari Mohd1, P.Swathimutyam1, A.Padmanabha Rao1, *Nalini Shastri2, and Prakash V Diwan1
1.Department of Pharmaceutics, School of Pharmacy (formerly Lalitha College of Pharmacy),Venkatapur, Ghatkesar,Hyderabad, AP ,India.
2.Department of Pharmaceutics, NIPER, Hyderabad, AP , India.
Abstract:-The present study was designed to develop a newer method for nano emulsions with glibenclamide as a anti diabetic drug. The method was carried out using (Gemini5µ C18 110A 100×4.60mm 5micron) with mobile phase comprised of methanol: 0.2M phosphate buffer PH 7.0 in the ratio (70:30). The flow rate at 1.0 ml/min and effluent was detected at 228nm. The retention time of glibenclamide was observed at 3.2 minutes. The method was validated for specificity, accuracy, precision, linearity, and limit of detection, limit of quantification, robustness and solubility. LOD and LOQ were 200 and 800 ng/ml respectively. The calibration curve was linear in the concentration range of 1- 2 µg/ml with coefficient correlation of 0.999. The percentage recovery for the glibenclamide was 99.8% and % RSD was less than 1 %. There are scanty reports with relation to determination of gliblencamide in nanoemulsion formulation. The proposed method was used for quantitative determination of glibenclamide in nano emulsion and is authenticated using various parameters.
Key words:- Glibenclamide, Anti diabetic drug, methanol, phosphate buffer, HPLC, Validation.
Research article:- * Panwar Mangal Singh1, Goyal Anju2
1.Mandsaur Institute of Pharmacy, Mandsaur, M.P -458001, India.
2.B.N. Girls College of Pharmacy, Udaipur , Rajashthan , India.
Abstract:- A simple, Precise, accurate, fast and economical methods have been developed for the quantitative estimation of Tenoxicam from tablet formulation using Erichrom black T. Tenoxicam forms a Blue colored chromogen with the reagent, which shows absorbance maxima at 421.5 nm and linearity in the concentration range of 5-25 µg/ml of drug. The results of analysis for the methods were validated statistically and by recovery studies.
Key Words:- Erichrom black T, Tenoxicam.
Original research article:- N. G. Raghavendra Rao*, M. Subhan
PG. Department of Pharmaceutics, Luqman College of Pharmacy Gulbarga- 585 102. Karnataka, India.
Abstract:- An attempt has been made for the development of fast dissolving tablets of the nimodipine by solid dispersion methods, using different concentrations of croscarmellose sodium as super disintegrating agent and study the effect of various carriers on solid dispersion technique. Nimodipine is used in the treatment of various cardiovascular disorders such as angina pectoris, cardiac arrhythmia and hypertension. The major problem of this drug is very low solubility in biological fluids and poor bioavailability after oral administration. The prepared tablets were evaluated for post-compressional parameters like hardness, friability, drug content, disintegrating time, wetting time, In-vitro dissolution studies and stability studies. The prepared tablets were characterized by DSC and FTIR Studies. No chemical interaction between drug and excipients was confirmed by DSC and IR studies. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The formulations prepared with mannitol solid dispersion were showed disintegration time between the ranges of 15.12 - 21.92 sec and drug release showed between the ranges of 09 - 11 min. However the formulations prepared with PEG‐6000 and PVP solid dispersions did not disintegrate in specified limit of time for fast dissolving tablet. Among all formulations SM4 prepared with mannitol as carrier showed 99.63 % drug release within 9 minutes. The results concluded that fast dissolving tablets of poorly soluble drug, Nimodipine showing enhanced dissolution will lead to improved bioavailability, improved effectiveness and hence better patient compliance. Finally it is concluded that effect of mannitol as a carrier on solid dispersion technique is excellent and shows best result.
Keywords:- Fast dissolving tablets, Nimodipine, croscarmellose sodium, Solid dispersion.
Original research article:- * Geetha RL 1, Manjunath BK 2, Vijayanath.V 3
1.Specialist(Dept of Pathology), No 12, 1 R Block, Rajajinagar, ESIC Model Hospital, Bangalore-10,India.
2.IMO,ESIC Model Hospital, 263/N, 6th c main,RPC layout, Bangalore, India.
3.Associate Professor, Department of Forensic Medicine & Toxicology, S.S.Institute of Medical Sciences & Research centre, Davangere-577005, Karnataka, India.
Abstract:- The distribution of ABO and Rh-D blood groups was studied among 26,288 subjects. They included blood donors, transfusion recipients and patients attending Employees State Insurance Corporation(ESIC) Model Hospital for medical interventions. The most common blood group was found to be group O [10,645, (40.5%)] followed by group B [7734(29.4%)],group A [6243,(23.7%)]and group AB [1,666(6.3%)]. The prevalence of Rh-D positivity and negativity was [24955 (94.9%)] and 1333 (5.01%) respectively.
Key Words:- ABO, blood group, Rh typing.
Research Article:-
*S.Durgaprasad1, Rai Reetesh2 , Kumar Hareesh2, Ravindrasingh Rajput2
1.Dept. of Pharmacology, American university of Antigua, College of medicine, Antigua. 2.Department of pharmacology, Kasturba Medical College, Manipal University, Manipal,India.
Abstract :- Back ground: Curcumin, a naturally occurring o-methoxyphenol derivative, has been shown to possess several biological properties including antioxidant (free radical scavenging activity), induction of detoxification enzymes and provides protection against degenerative diseases. Topical applications of compounds with free radical scavenging properties in patients have shown to improve significantly wound healing and protect tissues from oxidative damage. Objectives: To assess the effect of a topical curcumin preparation on healing of partial thickness burn wounds in rats. Methods: The rats are randomly divided into four groups, comprising of six rats in each group. Partial thickness burn wounds are created by pouring hot molten wax at 80ºC. Group I acts a control, Group 2 receives the standard silver sulphadiazine cream, Group 3 gets 20% curcumin cream, and Group 4 receives the combination of the dexamethasone and curcumin cream. Parameters observed are epithelialization period and wound contraction. Results & Discussion: The percentage of wound contraction was significantly increased in the topical curcumin preparation (20%) and silver sulfadiazine group compared to control group. The mean period of epithelization was significantly reduced in topical curcumin preparation (20%) group and silver sulfadiazine group as compared to the control. Conclusion: Topical curcumin preparation is effective in healing burn wound and the effect was comparable to that of standard drug i.e. silver sulfadiazine.
Keywords:- Topical curcumin, burn wound, epithelization period, wound contraction.