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Research article(Case Report):- * Balachandra S. Ankad 1, Sharada S. Patil 2, Vijay D. Dombale 3, Yamanur P Lamani.4
1.Department of Dermatology, S. Nijalingappa Medical College, Bagalkot , India.
2.Department of Pathology, S. Nijalingappa Medical College, Bagalkot , India.
3.Department of Pathology, S. Nijalingappa Medical College, Bagalkot , India.
4.Department of Surgery, S. Nijalingappa Medical College, Bagalkot , India.
Abstract:- Background: Liposarcoma is one of the most common soft tissue sarcoma in adulthood. Most frequently it arises in the retroperitonium, lower extremities and less often in the head and neck area. Only a few cases of scalp liposarcoma have been previously reported. Main observations: We report a case of lipomatous tumour of scalp in a 30 year old female. Wide surgical excision of the lesion was done under local anaesthesia and sent for histopathological examination. Microscopic picture revealed features suggestive of sclerosing atypical lipomatous tumour, dermis showed small clusters and isolated adipocytes with atypical features surrounded by hyalinizing fibrous stroma. After one year of follow up, the patient remained free of disease. Conclusions: Liposarcoma of head and neck is very rare, with only a handful of cases reported on scalp. Patients with cutaneous and subcutaneous atypical lipomatous tumour or well differentiated liposarcoma have a good prognosis, but there are reports of local recurrences after a long period, as well as high grade change and dedifferentiation. Hence careful follow up is required.
Key words:- Atypical lipomatous tumour, liposarcoma- scalp, sclerosing variant.
Research article:-
* I.O.George, A.I.Frank-Briggs Department of Paediatrics, University of Port Harcourt Teaching Hospital, Nigeria.
Abstract:-
Background: Children with sickle cell anaemia are often treated with blood transfusion which is an important route of transmission of the Human Immunodeficiency Virus (HIV).The aim of this study was to determine the prevalence of HIV infection among previously transfused children with sickle cell anaemia at the University of Port Harcourt Teaching Hospital(UPTH), Port Harcourt, Nigeria Methods: This was a prospective study of sickle cell anaemia patients with previous blood transfusion (aged 6 months to 16 years) attending the paediatric haematology clinic of UPTH, Port Harcourt, Nigeria from January 2008 to December 2009. Results: There were a total of 118 patients with previous blood transfusion from January 2008 to December 2009. Out of these, 66 (55.9 %%) were males while 52 (44.1%) were females .The Mean age (± 1 standard deviation) was 2.7 ±2.6 years (range 0.5-16 years). Five (4.2%) of 118 patients were HIV-seropositive. The parents of these patients were HIV-seronegative. However, the HIV-seropositive patients are being followed up at the paediatric HIV clinic of our hospital after post-test counseling. Conclusion: The HIV-seropositive rate in this study is comparable with national estimates thus highlighting the continued risks of inadequate blood banking systems in Nigeria.
Keywords:- HIV INFECTION, Sickle Cell Anaemia, Blood Transfusion, Port Harcourt, Nigeria.
Research article:- Bansal S. C.1,2 , Goswami N.1, Rai D. V.2,3, Sen R.4, Khandelwal N.1
1.Department of Radio-diagnosis and Imaging, PGIMER, Chandigarh, India.
2.Department of Biophysics, Panjab University, Chandigarh,India.
3.Department of Biomedical Engineering, Shobhit University, Meerut, U. P.,India. 4.Department of orthopedics, PGIMER, Chandigarh, India.
Abstract:- Objective:To design a reference phantom for both QCT and DEXA scanners to check their cross calibration and equipment stability as a part of daily quality control program. Materials and Methods: The specially designed phantom simulating lumbar spine consisting of three sections of femoral head (excised from patients who suffered from fracture neck of femur and underwent hip replacement) was scanned for Bone Mineral Density study both with Quantitative computed tomography (Light Speed plus CT Scanner of GE) and Dual energy X-ray absorptiometry (Norland XR46) scanner simultaneously for a period of 30 days and the results were analyzed. Results: During this study the mean BMD reading in QCT was 153.287 (mg/cc) with Std. Deviation of 2.2708 and coefficient of variation 1.48% whereas, the mean BMD reading in DEXA was 0.516 (g/cm2) with Std. Deviation of 0.0026 and coefficient of variation 0.50 . Both Std. Deviation and coefficient of variation in QCT and DEXA are within acceptable limits. Conclusion: Consistency in BMD readings of both QCT and DEXA scanners confirmed that this type of single phantom which is simple in design could be easily used to check the cross calibration and equipment stability as a part of daily quality control program. It has proved very simple, easy to perform and cost effective reference phantom for checking precision and accuracy in BMD measurements prior to examining a patient.
Key words:- BMD, calibration, DEXA, QCT, phantom.
Research article:-
Arvind K. Srivastava*, Savita Srivastava, Swayam Prakash Srivastava, Deepak Raina, Rehan Ahmad, M.N.Srivastava, Ram Raghubir and Vijai Lakshmi.
Divisions of Biochemistry, Medicinal and Process Chemistry, Botany and Pharmacology CSIR-Central Drug Research Institute, Lucknow-226001,India.
Abstract: The standardized ethanolic extract of the epicarp of the fruits of a marine mangroove Xylocarpus granatum have been found antihyperglycaemic and antidyslipidemic in nature. The yield of the extract by percolation method at room temperature varies between 8 to 14 % depending upon the season of collection. Studies in normal as well as streptozotocin-induced diabetic rats showed that the extract is effective in the improvement oral glucose tolerance post sucrose load. The extract was also found efficient in declining blood glucose profile of STZ-induced diabetic rats and both glucose as well as cholesterol and triglycerides levels in low dosed streptozotocin- high fructose fed rats and dyslipidemic hamsters. In neonatlly STZ-treated and fructose fed rats, the extract completely controlled their abnormal oral glucose tolerance and improved insulin resistance. The altered biochemical markers i.e. glucose-6-phosphatase, phosphofructokinase, phosphoenolpyruvate carboxykinase, pyruvate kinase, lactate dehydrogenase and glycogen phosphorylase in liver and kidney and except glucose-6-phosphatase, all the other markers in muscles of fructose fed as well as neonatally STZ-treated were also found towards normalization after the oral treatment of CDR-134 D123 at 250 mg/kg dose for three weeks. Controlled clinical trials are going on with this preparation for its usage in the management of type 2 diabetes mellitus.
Key words :-Xylocarpus granatum, Streptozotocin-induced diabetic rats, Neonatally STZ-treated rats, Low dosed STZ treated- high fructose fed rats, Dyslipidemia, hyperglycaemia, hypertriglyceridemia, db/db mice, hamsters, antidiabetic activity, antidyslipidemic activity.
Original research article:- *Dr. S. Swaminathan1, Dr. M. S. Seshadri2, Dr. A. S. Kanagasabapathy3
1.Sr. Consultant & Head, Biochemistry Department Apollo Speciality Hospital, Chennai -600 035, India.
2.Prof & Head, Endocrinology, Christian Medical College, Vellore-632004, India.
3.Former Prof of Clinical Biochemistry Christian Medical College, Vellore -632004 ,India.
Abstract:- Recently there has been considerable interest in the use of hair as an index to the status of essential trace metal metabolism in the body particularly zinc. In many respects hair is ideal for such use. The sample can be readily obtained without pain or trauma for the patient, is easily collected and requires no special equipment or storage. The concentration of the metal in the hair is high and large quantities of samples are easily available, making the task of the analyst easier. Further, hair does not readily deteriorate, and can be stored until it is convenient to perform the analysis. In this study we have established a Quality Control (QC) method for the day to day measurement of zinc in human hair making use of a pool of human hair collected from both men and women. The QC thus prepared shows good stability for a period of six months. The intra and inter assay precision (%CV) using such a hair QC were 3.6 and 5.9 respectively and both values are within acceptable limits.
Keywords:-Quality Control, Hair zinc, SD, %CV, Atomic Absorption Spectrophotometer