DocumentsDate added
Research article:- *Vijaykumar Nagabandi1, Ramarao Tadikonda2, K.N. Jayaveera3
1.M.Pharmacy, Department of Pharmaceutics, Vaageswari College of Pharmacy, Karimnagar, A.P, India
2.M.Pharm,Ph.D, Blue Birds College of Pharmacy, Hanamkonda, India.
3.Msc.Ph.D, Jawaharlal Nehru Technological University, Ananthapur,India.
Abstract:- Liquisolid technique is novel concept for delivery of drugs through oral route. This approach of delivering drugs is mostly suitable for lipophilic drugs and poorly or water insoluble drugs. It involves dissolving water insoluble drugs in non-volatile solvents and converting into acceptably flowing and compressible powders. The main objective of present investigation was to enhance the dissolution rate of water insoluble drug ketoprofen by using liquisolid technique. Several liquisolid tablets were prepared by using different carrier materials such as microcrystalline cellulose, and dicalcium phosphate, and coating material such as silica gel, respectively. Propylene glycol and tween80 were used as non volatile water miscible liquid vehicle. The ratio of carrier to coating material was kept constant in all formulations at 20 to 1. Before compression, powdered mass were evaluated for various parameters like flow properties, content uniformity etc. All the prepared formulations were compressed using 12mm punch after addition of 5 % Sodium starch glycolate (super disintegrating agent) to each formulation. The formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, friability, drug content uniformity, and disintegration time. The in-vitro release characteristics of the pure drug, drug from marketed tablets (as reference) and liquisolid technique (test sample), were studied. X-Ray Diffraction (XRD) and Fourier-Transform infrared spectroscopy (FT-IR) were performed. The results showed that liquisolid formulations of ketoprofen exhibited good micromeritic properties and higher percentage of drug release than marketed formulation. And it was concluded that there was no interaction between drug and excipients.
Keywords:- Liquisolid compacts, Ketoprofen, Dissolution, content uniformity.
Research article:- Goyal Parveen Kumar*1(M.Pharm.,PGDPL), Mittal Arun2 (M.Pharm.), Kumar Rishi3 (M.Pharm.)
1.Department of Pharmacology, Hindu College of Pharmacy, Sonepat-131001, Haryana,India.
2.Department of Pharmacognosy, Hindu College of Pharmacy, Sonepat-131001, Haryana,India.
3.Department of Pharmacognosy, IIMT College of Pharmacy, Greater Noida, India-201306.
Abstract: The present study was carried out to investigate the effect of ethanolic extract of Tinospora cordifolia (Wild.) Miers (Family: Menispermaceae) on calcium oxalate crystallization in urolithiasis. Calcium oxalate crystallization was induced by the addition of 0.01M sodium oxalate solutions in synthetic urine. The effect of extract (50, 100, 150, 200 and 250 µg/ml) was studied by time course measurement of turbidity in presence or absence of inhibitor (extract) at 620 nm for ten minutes by means of a spectrophotometer. The comparison between turbidimetric slopes with and without inhibitor gave percentage inhibition of crystallization hence the effectiveness of extract, and by comparing the photomicrographs with and without inhibitor, we concluded that T. cordifolia stem extract remarkably inhibited the calcium oxalate crystal formation hence can be stated to have antiurolithiatic potential.
Keywords:- Urolithiasis, Calcium oxalate, Tinospora cordifolia, Ethanolic extract.
Research article:- *Ara N. Patel1, Falguni M. Patel1, Kamal Singh Rathore1 .
1Bhupal Nobles’ Girls’ College of Pharmacy, Department of Pharmaceutics, Udaipur-313002, Rajasthan, India.
Abstract:- The purpose of the present study was to develop an optimized floating drug delivery system of diltiazem hydrochloride. Diltiazem floating tablets were formulated with different concentrations of two grades of HPMC polymers (HPMC K4M and HPMC K100M) by using wet granulation technique and evaluated for the different evaluation parameters such as thickness, diameter, drug content uniformity, friability, floating lag time, in-vitro buoyancy, in-vitro drug release studies and stability studies were performed. All the evaluation parameters results were significant. In-vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow both Higuchi and Korsemeyer and Peppas’ equation. The drug release mechanism was found Fickian type in most of the formulations. The prepared formulation shows better and significant results for all the evaluated parameters. The formulation A4 containing (HPMC K 4 M) shows maximum percentage of drug release (99.87 %) and prolonged release for time period of about 12 h, thereby improves the bioavailability and patient compliance.
Key words :- Floating drug delivery system, Diltiazem HCl, Buoyancy period, Higuchi plots, Accelerated stability studies.
Review article:- *Swapnil L. Patil , Madhavi A. Shivnikar
Pharamceutics department,Padm.Dr.D.Y Patil College of Pharmacy, Akurdi, Pune, Maharastra ,India ,411018.
Abstract:- The oral route remains the perfect route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. Fast disintegrating tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Fast disintegrating tablets are those when put on tongue, disintegrates instantaneously, releasing the drug, which disperses or dissolves in the saliva. Mouth dissolve tablets are also known as orodispersible, quick dissolve, fast melt, fast dissolve, fast disintegrate, rapid-dissolve, rapimelts or orally dissolve tablets. European pharmacopoeia recently adopted the term “Oro-dispersible tablet” as a tablet to be placed in mouth where it disappears rapidly before swallowing. Fast disintegrating tablets have received ever-increasing demand during the last decade and the field has become a rapidly growing area in the pharmaceutical industry.
Keywords:- Fast disintegrating tablets, Lyophilization, Direct compression
Research article:- Shenoy Revathi P, MSc, PhD 1 , * Bakkannavar Shankar M, MD, DCL 2, Vidya Monnappa, MD, Diplomate NB3, Bhat Akshay V,MSc 4, Mukesh Kumar, MSc,4 Nayak Vinod C, MD 5, Pradeep Kumar G, MD, Dip.Cr.L 6.
1.Assistant Professor, Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India.
2.Assistant Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Manipal,India.
3.Associate Professor, Department of Pathology, Kasturba Medical College, Manipal University, Manipal, India.
4.Postgraduate, Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India.
5.Associate Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Manipal, India.
6.Professor & Head, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Manipal, India.
Abstract:- Myocardial infarction is the most common cause of sudden death. However the identification of myocardial infarcts at necropsy is difficult. Various methods are being used to detect it. It has been shown that the use of dyes such as nitroblue tetrazolium and 2,3,5 triphenyl tetrazolium chloride (TTC) that identify the dehydrogenase deficient infracted myocardium are largely used. But the studies have been conducted largely in animal models using these dyes. Establishing the utility of these enzyme histochemical tests at autopsy on human cadavers is the need of the hour. We studied the fourty hearts of sudden death cases staining them with TTC and thereafter confirming with histology to know the efficacy of TTC staining. Our results showed that this histochemical test is a reliable method of investigation in sudden death cases.
Key words:- Myocardial infarction, 2,3,5 triphenyl tetrazolium chloride, histochemical tests.