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Review article:- Piplani S1, * Lalit M2, Arora AK3.
1.Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab,India. 2.Chintpurni Medical College,Bungal, Pathankot, Punjab, India.
3.Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.
Abstract-: Glucagonomas an uncommon clinicopathological entity originate from the alpha-2 cells of the pancreas The syndrome goes by the acronym 4D syndrome, which stands for dermatosis, diarrohea, deep vein thrombosis and depression. Necrolytic migratory erythema (NME) is the most characteristic clinical sign of this pathology. It is associated with hyperglucagonemia, diabetes mellitus, hypoaminoacidemia, cheilosis, normochromic, normocytic anemia, and weight loss. NME features a characteristic skin eruption of red patches with irregular borders, intact and ruptured vesicles, and crust formation.The tumor cells are occasionally organized in nests and strands and appear strongly glucagon-positive on immunohistochemical staining. The correct recognition of NME is very important, because it may allow early detection either of glucagonoma or of extrapancreatic, glucagon-secreting tumors. Glucagonoma is a slow growing tumor and good recovery is possible after surgical resection.
Key words:- Glucagonoma, Hyperglucagonemia, Necrolytic migratory erythema (NME), Diabetes mellitus.
Review article:- Munish Garg, *Monika Hooda, Jyoti Solanki, Sandeep Saini, Sneha Das.
Department of Pharmaceutical Sciences, Maharshi Dayanand University Rohtak, 124001, India.
Abstract:- Adulteration of herbal supplements with undeclared synthetic drugs or by mixing the analogues of prescription can cause a significant risk to public hAealth. Consumers of such adulterated products are at risk of developing serious adverse reactions, potentially leading to pulmonary hypertension, moderate aortic regurgitation, a prominent right heart failure, hypokalemia and even death. These analogues are not declared on the labeling and often created by replacing or adding functional groups to the original chemical. Thus, herbal manufacturers have made it more difficult for the analysts to detect these undeclared pharmaceutical analogues into their products. Although DSHEA has given responsibility to the FDA to enforce guidelines for safety and claims, but as per the regulations, FDA can investigate a supplement only after a safety problem has been reported in a particular formulation thus giving the herbal manufacturers enough courage to launch their unscrupulous products into the market. Therefore, a current need arises to check these practices for the proper quality control of these herbal formulations. In this regard, the enforcement of strict manufacturing guidelines, approval process and quality control conditions may well be a step forward towards the safer use of industrially produced herbal products. Moreover, quality and efficacy of medicinal products should be assessed by randomised clinical trials (RCT) before licenses can be issued.
Key words:- Herbal formulations, quality control of herbals, synthetic adulterants in herbals.
Research article:- *Ara N. Patel1, Falguni M. Patel1, Kamal Singh Rathore1 .
1Bhupal Nobles’ Girls’ College of Pharmacy, Department of Pharmaceutics, Udaipur-313002, Rajasthan, India.
Abstract:- The purpose of the present study was to develop an optimized floating drug delivery system of diltiazem hydrochloride. Diltiazem floating tablets were formulated with different concentrations of two grades of HPMC polymers (HPMC K4M and HPMC K100M) by using wet granulation technique and evaluated for the different evaluation parameters such as thickness, diameter, drug content uniformity, friability, floating lag time, in-vitro buoyancy, in-vitro drug release studies and stability studies were performed. All the evaluation parameters results were significant. In-vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow both Higuchi and Korsemeyer and Peppas’ equation. The drug release mechanism was found Fickian type in most of the formulations. The prepared formulation shows better and significant results for all the evaluated parameters. The formulation A4 containing (HPMC K 4 M) shows maximum percentage of drug release (99.87 %) and prolonged release for time period of about 12 h, thereby improves the bioavailability and patient compliance.
Key words :- Floating drug delivery system, Diltiazem HCl, Buoyancy period, Higuchi plots, Accelerated stability studies.