DocumentsDate added
Review article:- *Swapnil L. Patil , Madhavi A. Shivnikar
Pharamceutics department,Padm.Dr.D.Y Patil College of Pharmacy, Akurdi, Pune, Maharastra ,India ,411018.
Abstract:- The oral route remains the perfect route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. Fast disintegrating tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Fast disintegrating tablets are those when put on tongue, disintegrates instantaneously, releasing the drug, which disperses or dissolves in the saliva. Mouth dissolve tablets are also known as orodispersible, quick dissolve, fast melt, fast dissolve, fast disintegrate, rapid-dissolve, rapimelts or orally dissolve tablets. European pharmacopoeia recently adopted the term “Oro-dispersible tablet” as a tablet to be placed in mouth where it disappears rapidly before swallowing. Fast disintegrating tablets have received ever-increasing demand during the last decade and the field has become a rapidly growing area in the pharmaceutical industry.
Keywords:- Fast disintegrating tablets, Lyophilization, Direct compression
Research article:- *Vijaykumar Nagabandi1, Ramarao Tadikonda2, K.N. Jayaveera3
1.M.Pharmacy, Department of Pharmaceutics, Vaageswari College of Pharmacy, Karimnagar, A.P, India
2.M.Pharm,Ph.D, Blue Birds College of Pharmacy, Hanamkonda, India.
3.Msc.Ph.D, Jawaharlal Nehru Technological University, Ananthapur,India.
Abstract:- Liquisolid technique is novel concept for delivery of drugs through oral route. This approach of delivering drugs is mostly suitable for lipophilic drugs and poorly or water insoluble drugs. It involves dissolving water insoluble drugs in non-volatile solvents and converting into acceptably flowing and compressible powders. The main objective of present investigation was to enhance the dissolution rate of water insoluble drug ketoprofen by using liquisolid technique. Several liquisolid tablets were prepared by using different carrier materials such as microcrystalline cellulose, and dicalcium phosphate, and coating material such as silica gel, respectively. Propylene glycol and tween80 were used as non volatile water miscible liquid vehicle. The ratio of carrier to coating material was kept constant in all formulations at 20 to 1. Before compression, powdered mass were evaluated for various parameters like flow properties, content uniformity etc. All the prepared formulations were compressed using 12mm punch after addition of 5 % Sodium starch glycolate (super disintegrating agent) to each formulation. The formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, friability, drug content uniformity, and disintegration time. The in-vitro release characteristics of the pure drug, drug from marketed tablets (as reference) and liquisolid technique (test sample), were studied. X-Ray Diffraction (XRD) and Fourier-Transform infrared spectroscopy (FT-IR) were performed. The results showed that liquisolid formulations of ketoprofen exhibited good micromeritic properties and higher percentage of drug release than marketed formulation. And it was concluded that there was no interaction between drug and excipients.
Keywords:- Liquisolid compacts, Ketoprofen, Dissolution, content uniformity.
Original research article:- Dr.S.Swaminathan Ph.D1, Ms.Priya Gangadaran M.Sc, M.Phil1, Mr.T.Venkatesh2 Dr.Mitra Ghosh M.D3
1.Biochemistry department, Apollo Speciality Hospital, Chennai -35, India.
2.B.Tech , M.G.R University,Chennai -84, India.
3.Chief of Lab Services, Apollo Speciality Hospital, Chennai -35, India.
Abstract:- Copper is believed to be the switch that turns on the angiogenesis process in tumor cells, by activating the growth factor. Copper is necessary for fetal growth as well as in the production of hemoglobin . This study was undertaken on 40 female patients. in the age group of 16 to 62 years to establish the diagnostics utility of serum copper measurement along with the two tumor markers CEA and CA125. While copper measurement was done using a manual method, CEA and CA125 assays were carried out is fully automatic Roche diagnostic Elecsys 2010 which uses electrochemiluminescence technology. Appropriate quality controls were used to validate the accuracy of the results obtained. Excellent correlation (p<0.0001) between Cu and both the tumor markers were obtained thereby showing a very strong association between serum copper and the two tumor markers. This study concludes that measurement of serum copper along with the two tumor markers will be diagnostically useful in cancer screening / remission.
Key Words:- Copper, CEA, CA 125.
Health and Safety Survey:- *Javed Akhter, PhD, Sameera Al Johani, MD, Loulwah Hammad, BSc, Khalid Al Zahrani, MSc.
*Director, Quality Management and Laboratory Safety,Pathology and Laboratory Medicine, Mail Code 1122,P.O. Box 22490,King Abdulaziz Medical City,Riyadh 11426,Saudi Arabia.
Abstract:- A Health and Safety survey was conducted among Laboratory workers in the Pathology Laboratory at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Analysis of 154 completed questionnaires showed that the majority of respondents were female (61%) with most participants under the age of 30 years (49%). 88% of respondents regularly worked with blood and blood products. It was found that 14% had suffered a needle stick injury and 8% had received splashes to the eyes or mouth; 2% had not reported these exposures. Full compliance of wearing gloves at all times when working with blood and blood products was 92%. Only 61% of respondents washed their hands after removing gloves. There was also a low compliance of using goggles/face shields when handling body fluids outside of a biological safety cabinet (17%). Reasons given were lack of availability (30%), not thought necessary (18%) and interfered with job (8%). Total compliance for safe disposal of sharps in a sharps container was 92%. This first report in Saudi Arabia identified several deficiencies and strategies for improvement. These results are essential in formulating effective health and safety measures and provide relevant and focused education to reduce occupational related hazards and injuries.
Keywords:- Occupational hazards, laboratory workers, laboratory hazards.
Original research article:- *M.P.Saraswathy1, U.M. Dhanalekshmi2
1.M.D Microbiology, Assistant Professor of Microbiology, Melmaruvathur Adiparasakthi Institute of Medical sciences & RI, Melmaruvathur,Tamilnadu- 603319 ,India.
2.M .Pharm PhD, SRF, Dept of Bio-organic, CLRI, Chennai,Tamilnadu, India.
Abstract:- Plants are among the most important and common sources of potentially valuable new drugs. Use of herbal products as antimicrobial agents may provide the best alternative to the wide and injudicious use of synthetic antibiotics. The aim of this study was to determine the level of antimicrobial activity of aqueous and methanolic extract of Evolvulus alsinoides (EA) towards 9 bacterial isolates and 5 fungal isolates. The study was conducted at department of Microbiology, Melmaruvathur AdhiParasakthi Institute of Medical Sciences and Research. The assays were performed using disc diffusion method and MIC was calculated by agar dilution method. Ciprofloxacin was used as a standard reference drug. In our study, aqueous extract displayed strong antimicrobial activity against Staphylococcus aureus, S.epidermidis, Klebsiella pneumoniae and Vibrio cholera. The MIC value 133µg/ml of methanolic extract was inhibitory to most of the gram negative organisms tested, except E.coli. The aqueous extract was effective against all the fungal isolates tested at MIC of ≥166 µg/ml. The identified phytochemical compounds viz., flavonoids and alkaloids may be responsible for the antimicrobial activity of EA. The study shows that plant extract has wide antimicrobial as well as antifungal activity. Therefore, it supports the traditional use of the plant in the treatment of infectious diseases like Enteric fever, Cholera and fungal skin diseases caused by candida and dermatophyte.
Key words:- Aqueous extract, Antimicrobial activity, Antifungal activity, Evolvulus alsinoides, Methanolic extract, MIC.