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Research article:- Harison Masih1, Ajay Kumar Singh1, Yashab Kumar1, Aviral Srivastava1, Ravi Kant Singh*2, Santosh Kumar Mishra2, Kumar Shivam2.
*1.Dept. of Microbiology & Fermentation Technology, Sam Higginbottom Institute of Agriculture Technology & Sciences, Allahabad, U.P., India.
2.Department of Biotechnology, IMS Engineering College, Ghaziabad, U.P., India.
Abstract:- Production of a family of lipopetide antibiotic by using mutated strain B. subtilis in submerged fermentation system was investigated. The mutated strain M40 showed a higher antagonistic activity than wild strain of B. subtillus against the plant pathogens Erwinia carotovora var. carotovora. The mutated strain was inoculated in three different liquid culture media CPG, CPM, CPMCa++ to study the level of production of inhibitory substances & CPMCa++ was found best culture medium against plant pathogens. The antagonistic strain M40 was more active than wild strain and obtained metabolite was thermostable, protease resistance and classified as producer of antibiotic of metabolite group.
Key words:- Lipopetide antibiotic, B. subtilis, Mutated strain, Erwinia carotovora var. carotovora, Plant pathogens
Research article:- 1*Gohel Salim D., 2Patel KS, 3Harisha C.R. 4Shukla VJ,
1.*Ph.D. Scholar, Department of Kaumarabhritya, IPGT & RA, Gujarat Ayurved University, Jamnagar, Gujarat, India – 361 008.
2.Associate Professor and Head, Department of Kaumarabhritya, IPGT & RA, Gujarat Ayurved University, Jamnagar, Gujarat, India – 361 008.
3.Head, Pharmacognosy Laboratory, IPGT & RA, Gujarat Ayurved University, Jamnagar, Gujarat, India – 361 008.
4.Head, Pharmaceutical Chemistry laboratory, IPGT&RA, Gujarat Ayurved University, Jamnagar, Gujarat, India – 361 008.
Abstract:-Tuberculosis (TB) remains a major public health problem in India. Every year approximately 18 lakh people develop TB and about 4 lakh die from it. About one million children develop tuberculosis (TB) annually worldwide, accounting for about 11% of all TB cases. Lots of single and compound drugs have been described in Ayurvedic classics for the management of Rajayakshma (Tuberculosis). Ikshvadi Avaleha is one among them and is very safe to be used in children. The objective of this work is to standardize Ikshvadi Avaleha by means of pharmacognostical and pharmaceutical analysis. Pharmacognostical study that consists of both macroscopic and microscopic features of raw drug exposed to the quality and genuineness of all the constituents of Ikshvadi Avaleha, Specific gravity of prepared Avaleha was 1.245 and pH was 8.2. TLC and HPTLC were carried out after organizing appropriate solvent system in which maximum 4 spots were distinguished in TLC and 3 spots in HPTLC and most of the Rf values were identical when done with different sample extractive methods. It is inferred that the formulation meets the minimum qualitative standards as reported in the API at a preliminary level. The inference from this study may be used as reference standard in the further quality control researches.
Key Words:- Rajayakshma (Tuberculosis) Ikshvadi Avaleha, Pharmacognosy, Physico-chemical Analysis.
Research article:- * Salah I. Kheder
Ph.D Pharmacology - National college of Medical & Techenical sciencies National college of Medical & Techenical sciencies– Pharmacy program , Khartoum – Sudan,3783 Khartoum.
Abstract:-Most hospitals in Sudan consumed large amount of cephalosporin antibiotics, particularly in surgical departments as the preferred choice for prophylaxis. The present study audited the use of cephalosporin in a general hospital surgical setting and investigated the resistance rates to the different cephalosporin antibiotics used. Consumption of cephalosporin antibiotics calculated, and surveillance susceptibility results was obtained on a daily base for 2 years from May 2008 to May 2010, from hospital microbiology laboratory and analyzed every 3-4 months. Consumption was significantly decreased from 270 DDDs/1000 patient-days at the beginning of observational periods to 104 DDDs/1000 patient-days for the last 3 months of intervention period (representing a 61.6% decrease), but high resistance rates remained almost unchanged. Appropriate infection control and antibiotic management strategies are needed to stem the spread of this emerging of resistance.
Key words :- Antibiotic resistance, Antibiotic policy, Extended-Spectrum β-Lactamases, ESBLs.
Research article:- *Cheraladhan E. Sambandam1 Sejal N. Sailor2 Jagatheesan Alagesan3
*1.Cheraladhan E. Sambandam, Assistant Professor, College of Physiotherapy, Sumandeep Vidyapeeth, Vadodara, India.
2.Sejal N. Sailor, PG Student, College of Physiotherapy, Sumandeep Vidyapeeth, Vadodara, India.
3.Jagatheesan Alagesan, Associate Professor, College of Physiotherapy, Sumandeep Vidyapeeth, Vadodara, India.
Abstract:- Background & Objective: Osteoarthritis (OA) is the most common joint disease causing disability. Current physical therapy management for knee OA is aiming to increase range of motion and improve functional performance. The purpose of this study is to find out the effectiveness of mobilization technique either Mulligan’s Mobilization or Maitland Mobilization for improving the unilateral tibiofemoral joint ROM and functional performance in of unilateral osteoarthritis. Methods: Sixty subjects with osteoarthritis of Tibiofemoral joint were selected for the study and randomly divided in to three groups of 20 subjects. Group A received Mulligan mobilization, Group B received Maitland Mobilization and Group C received conventional treatment. ROM was measured by Goniometry and functional performance was measured by WOMAC scale pre and post treatment by blinded tester. Results: Intragroup comparison of ROM showed significant improvement in three group but Mulligan group showed very highly significant (p< 0.001) improvement. WOMAC score showed significant (p=0.005) improvement in all three groups. Conclusion: In this study all groups have shown significant difference in improving ROM, and improving functional performance but mulligan group showed more improvement than Maitland group and control group.
Keywords:- Tibiofemoral Osteoarthritis, Mulligan Mobilization, Maitland Mobilization.
Review article:- * Yerram Raju Behara
*B.Pharm, Department of Pharmacology, Sri Indu Institute of Pharmacy, affiliated to Jawaharlal Nehru Technological University, Hyderabad ,India.
Abstract:-Artichoke leaf consists of the fresh or dried leaf of Cynara scolymus Artichoke leaf extract is made from the long, serrated basal leaves of the plant in which is found the highest concentration of biologically active compounds .Artichoke extract is one of the few herbal remedies where the clinical and experimental trials have complemented each other. Both experimental and clinical effects have been verified through extensive biomedical herbal remedy research. Specifically, antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering effects have been demonstrated, which correspond with its historical use. Ongoing research seems to indicate that artichoke does indeed have medicinal qualities. Most significant appears to be its beneficial effect on the liver. In animal studies, liquid extracts of the roots and leaves of artichoke have demonstrated an ability to protect the liver, and possibly even to help liver cells regenerate. Although research is not yet conclusive, scientists are optimistic that its long-standing use in humans for digestive and bowel problems is indeed justified. It may also play a role in lowering cholesterol and thus help to prevent heart disease. Boiled wild artichoke reduces postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients. This article intends to review the wide ranging pharmacological effects of artichoke.
Key words :- Artichoke, Cynara scolymus , antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering, postprandial glycemic and insulinemic responses, metabolic syndrome, HIVinhibitor.