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Research article:- Jahir Alam Khan1 , * Krishna Pratap Yadav2
1.R &D Division, MRD LifeSciences (P) Ltd., Lucknow (U.P), India.
2.Department of Biotechnology, R.M.L. Awadh University, Faizabad (U.P). India.
Abstract:-Cold and hot water, methanol, ethanol, ethyl acetate, acetone, and hexane extracts of leaves, stem and roots of Ricinus communis in a final concentration of 500mg/ml were evaluated for their antifungal properties against pathogenic microorganisms such as Trycophyton rubrum, Candida albicans, Microsporum Spp. using agar well diffusion method. In case of leaf cold aqueous, methanolic and acetone extracts were effective. Only cold aqueous extract of stem was effective. Cold aqueous extract of root was most effective followed by acetone, ethyl acetate and hexane extracts. MIC was also calculated for the most effective extracts and it was found to be 31.25mg/ml.
Key words :- Antifungal properties, Ricinus communis, Pathogens, Solvent extraction, Agar well diffusion
Research article:- *Ashish Jain1, Satish Nayak2, Vandana Soni3 *
1 M.Pharm, Assistant Professor, Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India.
2.Ph.D., Director, Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, India.
3.Ph.D., Professor, Department of Pharmaceutical Sciences, Dr H.S.Gour Vishwavidyalaya, Sagar 470003, M.P. India.
Abstract:- The pupose of the present work was to assess iontophoretic transdermal delivery of Captopril across pigskin for its transdermal development. In vitro iontophoretic transdermal delivery of Captopril across the pigskin was investigated at three different drug concentrations and tree different current densities (0.25- 075 mA/cm2 ) in the donor cell of the diffusion apparatus, using cathodal iontophoresis along with the passive controls. For passive permeation, the steady state flux significantly increased with the donor drug concentration. At all concentration levels, iontophoresis considerably increased the permeation rate compared to passive controls. Iontophoretic transport of Captopril was to be found with current densities. Flux enhancement was highest at the lowest drug load and lowest at the highest drug load. We concluded permeation rate of drugs across the pigskin can be considerably enhanced by the use of Iontophoresis.
Keywords: Captopril; Iontophoresis; Pigskin; Transdermal drug delivery.
Review article:- Arun Mittal*1 (M.Pharm.), Satish Sardana1 (M.Pharm., Ph.D.), Anima Pandey2 (M.Pharm., Ph.D.) .
1.Department of Pharmacognosy, Hindu College of Pharmacy, Sonepat-131001, Haryana , India.
2.Department of Pharmaceutical Sciences, Birla Instiute of Technology, Mesra, Ranchi-835215, Jharkhand ,India.
Abstract:- Jasminum sambac Ait. commonly known as ‘Motia’ is an evergreen plant, belongs to family Oleaceae and has been extensively used in traditional medicine. It possesses immense medicinal applications such as to cure insanity, weakness of sight, affections of mouth, skin diseases, leprosy, ulcers and in suppression of puerperal lactation. It also possesses antidiabetic, antitumour, antimicrobial, antioxidant, antiacne, woundhealing properties and has A.N.S stimulating effect. The plant contains sambacin, jasminin, sambacoside A, sambacolignoside, quercitin, isoquercitin, rutin, kaempferol, luteolin, phenyl methanol, linalool, alpha-terpineol, friedelin, lupeol, betulin, alpha amyrin, ursolic acid, and Seco-irridoid glucoside- sambacoside A-G along with oleoside 11-methylester. Present review summarizes phytochemistry, pharmacology, traditional claims, substantiated medicinal properties and biological activities of J. sambac and its usage in different ailments.
Keywords:- Jasminum sambac, Ethnobotany, Phytochemistry, Pharmacological activities.
Research article:- *Amit Pandey1, Rajesh Kumar2
1.R&D Division, MRD LifeSciences, Lucknow-226010, India.
2.Institute of Biosciences & Biotechnology, CSJM University, Kanpur -802024, India.
Abstract :-The antibacterial properties of “Lawsonia inermis” commonly known as “Henna or Mehandi” tested against bacterial pathogens (S. aureus, P. aeruginosa and E. coli). Agar diffusion susceptibility test revealed inhibition zone of Henna sample. The Henna leaves were exhibiting best result followed by fruits, bark root and stems. The solvents were used ethanol, methanol, ethyl acetate and hot water, compare to all, ethanolic extract and ethyl acetate extract were showing best result against one gram positive culture Staphylococcus aureus (MTCC 2940) and two gram negative cultures Pseudomonas aeruginosa (MTCC 2453) and E. coli (MTCC 739). The MIC value was determined by using broth dilution methods. Ethanolic extract of Henna was subjected to get the MIC against test organisms and it was found to be 1.45 mg/ml for E. coli and Pseudomonas aeruginosa.
Keywords:- Antibacterial properties, ethanolic and ethyl acetate plant extract, MIC, zone of inhibition.
Review article:- * Nahida Tabassum1, Andleeb Bashir2, Amreen Naqash3, Saima Rasool 4, Mubashir H Masoodi 5
Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006.India.
Abstract:-Immunodeficiency disorders involve malfunction of the immune system, resulting in infections that develop and recur more frequently, are more severe, and last longer than usual. AIDS is an immunodeficiency disease caused by HIV (human immunodeficiency virus). People with HIV have what is called HIV infection. Most of these people will develop AIDS as a result of their HIV infection and symptoms they develop are known as AIDS defining condition. The latest statistics of the global HIV and AIDS epidemic, published by UNAIDS in 2008 reported that 31.1-35.8 million people were living with HIV/AIDS. Although newer advances have been introduced in the treatment of HIV, still research is going on. Several recent major developments in human immunodeficiency virus treatment, prevention, outcome, and social policy changes have taken place. Updated international guidelines endorse more aggressive treatment strategies, safer antiretroviral drugs and gene therapies in treatment of HIV syndrome. New antiretroviral options are being tested. Vaccines and microbicide gels are under trials, and additional trials in prevention, especially pre-exposure prophylaxis, are nearing completion. Insight into the role of the virus in the pathogenesis of diseases, traditionally thought to be unrelated to acquired immunodeficiency syndrome, has become a driving force for earlier and universal therapy.
Key words :- AIDS; Antiretroviral therapy, HIV vaccine, Human immunodeficiency virus, Multitalented protein sheds.