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Research article:- * Vidyadhar B. Bangal1, Purushottam A. Giri2, Bhushan M. Sali3.
1Professor and Head, Dept. of Obstetrics and Gynaecology (OBGY), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni, Dist. Ahmednagar, Maharashtra, India.
2Assistant Professor, Dept. of Community Medicine (PSM), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni Dist. Ahmednagar, Maharashtra, India.
3Postgraduate student, Dept. of Obstetrics and Gynaecology (OBGY), Rural Medical College & Pravara Rural Hospital of Pravara Institute of Medical Sciences (Deemed University), Loni Dist. Ahmednagar, Maharashtra, India.
Abstract:- Oligohydramnios or reduced amount of amniotic fluid volume is a commonly observed obstetric problem during third trimester of pregnancy. It accompanies a broad range of reproductive disorders including anomalies of fetus and functional disorders of mother, fetus and placenta. Reduced amniotic fluid volume is associated with adverse perinatal outcome. A prospective hospital based study of total 100 cases of oligohydramnios coming for delivery to Pravara Rural Hospital, Loni was undertaken over a period of two years from October 2007 to September 2009. The information regarding bio-social characteristics, maternal and perinatal outcome were collected and results were analyzed by using percentage and proportion. In the present study, the majority of the cases( 78%) were unbooked and belonged to the age group of 20-30 years and had associated maternal or fetal complications. Postdated pregnancy, pregnancy induced hypertension and fetal congenital anomalies were the commonest complications associated with oligohydramnios. Forty four percent cases were delivered by caesarean section. Overall perinatal mortality was 24%. Cases with severe oligohydramnios and anhydramnios were associated with intrapartum fetal heart rate abnormalities, (16%) low Apgar score and (8%) meconium aspiration syndrome. Every case of oligohydramnios needs careful evaluation, parental counseling and individualized decision regarding timing and mode of delivery. Continuous intrapartum fetal monitoring and good neonatal care support is essential for optimum perinatal outcome.
Keywords:- Maternal outcome, perinatal outcome, Oligohydramnios.
Research article:- *Kunal Madhav1, Satish Verma2, Ritu Tanta3 .
1Lecturer, Department of Microbiology, Sai Institute of Paramedical And Allied Sciences, Dehradun, Uttarakhand, India.
2Lecturer, Department of Biotechnology, Sai Institute of Paramedical And Allied Sciences, Uttarakhand ,India.
3Department of Microbiology , Sai Institute of Paramedical And Allied Sciences, Dehradun, Uttarakhand, India.
Abstract:- The present work is focused on the isolation of Bacillus spp. from the soil sample of industrial, city and agricultural land in Dehradun (Uttarakhand). The collected samples were labeled as Agricultural soil sample (ASB), Industrial soil sample (ISB) and city soil sample (CSB). Soil samples were then serially diluted in normal saline and plated on sterile nutrient agar plates. The colonies obtained from higher dilutions were subjected to Gram staining, biochemical reactions and starch hydrolysis test. Bacterial colony yielding positive starch hydrolysis test were subjected to Amylase activity test. The amylase activity was also carried on the isolated bacteria with respect to time, temperature and pH of the media in which it was inoculated. The result showed that the maximum amylase activity in case of Agricultural soil (34.2%) followed by city sample (26.07%) and industrial sample (21.79%). Amylase activity was also checked with respect to temperature, time and pH. The activity of amylase was seen to increase with respect to time, pH and temperature which was found to be 18.33 IU, 6.89 IU and 6.85 IU in case of Agricultural soil bacilli respectively; whereas both city and industrial soil sample yielded comparatively low results.
Keywords:- Amylase activity, Bacilli, Soil, pH effect.
Review article:- *Srujan Reddy1, Palash Das1, Harika Das1, Arpita Ghosh2.
*1Department of Pharmaceutics, SRM University, Chennai, India.
1Department of Pharmaceutics, MLR Institute of Pharmacy, Dundigal, Hyderabad, India.
2Department of Pharmaceutics, Bojjam Narsimhulu College for Women, Hyderabad , India.
Abstract:-Compaction of multiparticulates, commonly called MUPS, is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. This article reviews the advantages and drawbacks of MUPS, properties of an ideal MUPS dosage form, mechanisms involved in their compaction, their disintegration and dissolution behavior, objectives/rationale involved in the design of MUPS dosage form, challenges in their compaction and key variables to be considered in successful production of MUPS.
Key words:- MUPS, multiparticulates, pellets, tablets, compaction, compression, tabletting.
Original research article:- *Buch Pankaj M1, Parmar Parin2, Doshi Smita K3, Chudasama Rajesh K4.
1M.D. (Pediatrics) ,Professor, Department of Pediatrics, M P Shah Medical College, Jamnagar, Gujarat, India.
2M.D. (Pediatrics) , Assistant Professor, Department of Pediatrics, P D U Medical College, Rajkot, Gujarat, India.
3M.D. (Pediatrics), Professor & Head Department of Pediatrics, P D U Medical College, Rajkot, Gujarat, India.
4M.D. (Community Medicine) , Associate Professor, Department of Community Medicine, M P Shah Medical College, Jamnagar, Gujarat, India.
Abstract:- Objective: To evaluate possible predictors of immediate outcome in non-traumatic coma in children with infective etiology. Method: An observational prospective study was conducted over a period of 15 months from 1st June 2009 to 31st August 2010 at Department of Pediatrics, Government Medical College, Rajkot, Gujarat, India. Children aged 6 months to 12 years presenting with non-traumatic coma with history, clinical features and laboratory studies suggestive of infective etiology were followed upto immediate outcome. A complete history, general and systemic examination at presentation was recorded. Relevant laboratory and radiological investigations were performed and GCS was recorded every 6 hourly until the immediate outcome. The etiology of coma was determined on the basis of history, clinical examination and investigations. Results: CNS infections (n=34), Respiratory tract infections (n=26) and sepsis (n=34) were most common etiology of non traumatic coma. Severe malnutrition and Anemia were comman associated conditions. Thirty Eight (40.4%) survived and Fifty six patients (59.6%) died. survival was better with Meningitis compared to sepsis (p=0.007). GCS <5 on admission, Shock on presentation, Hypothermia, associated severe Malnutrition and significant anemia, Severe dehydration,, abnormal breathing Pattern, Nonreactive Pupils and jaundice correlated significantly with mortality. On logistic regression poor pulse volume, GCS at 24 hrs <5, CNS infection, Jaundice; severe dehydration and significant Anemia were independent significant predictors of death. Conclusion: CNS infections, Respiratory infections and sepsis were most comman cause of non traumatic coma. Shock and Severe Malnutrition contributes to adverse outcome. Simple clinical signs and GCS were good predictors of outcome.
Keywords:- Non-traumatic coma in children, infective etiology, Predictors of mortality.
Letter to the editor:-
*Dr. M. Dheepa1, Dr. B. Appalaraju2, Ms. S. Chithra 3.
1Associate Professor, Department of Microbiology, PSG Institute of Medical Sciences & Research , Peelamedu, Coimbatore- 641004, Tamil Nadu, India.
2Professor and Head, Department of Microbiology, PSG Institute of Medical Sciences & Research , Peelamedu, Coimbatore- 641004, Tamil Nadu, India.
3PSG Institute of Medical Sciences & Research, Peelamedu, Coimbatore- 641004, Tamil Nadu, India.