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Original research article:- *Buch Pankaj M1, Parmar Parin2, Doshi Smita K3, Chudasama Rajesh K4.
1M.D. (Pediatrics) ,Professor, Department of Pediatrics, M P Shah Medical College, Jamnagar, Gujarat, India.
2M.D. (Pediatrics) , Assistant Professor, Department of Pediatrics, P D U Medical College, Rajkot, Gujarat, India.
3M.D. (Pediatrics), Professor & Head Department of Pediatrics, P D U Medical College, Rajkot, Gujarat, India.
4M.D. (Community Medicine) , Associate Professor, Department of Community Medicine, M P Shah Medical College, Jamnagar, Gujarat, India.
Abstract:- Objective: To evaluate possible predictors of immediate outcome in non-traumatic coma in children with infective etiology. Method: An observational prospective study was conducted over a period of 15 months from 1st June 2009 to 31st August 2010 at Department of Pediatrics, Government Medical College, Rajkot, Gujarat, India. Children aged 6 months to 12 years presenting with non-traumatic coma with history, clinical features and laboratory studies suggestive of infective etiology were followed upto immediate outcome. A complete history, general and systemic examination at presentation was recorded. Relevant laboratory and radiological investigations were performed and GCS was recorded every 6 hourly until the immediate outcome. The etiology of coma was determined on the basis of history, clinical examination and investigations. Results: CNS infections (n=34), Respiratory tract infections (n=26) and sepsis (n=34) were most common etiology of non traumatic coma. Severe malnutrition and Anemia were comman associated conditions. Thirty Eight (40.4%) survived and Fifty six patients (59.6%) died. survival was better with Meningitis compared to sepsis (p=0.007). GCS <5 on admission, Shock on presentation, Hypothermia, associated severe Malnutrition and significant anemia, Severe dehydration,, abnormal breathing Pattern, Nonreactive Pupils and jaundice correlated significantly with mortality. On logistic regression poor pulse volume, GCS at 24 hrs <5, CNS infection, Jaundice; severe dehydration and significant Anemia were independent significant predictors of death. Conclusion: CNS infections, Respiratory infections and sepsis were most comman cause of non traumatic coma. Shock and Severe Malnutrition contributes to adverse outcome. Simple clinical signs and GCS were good predictors of outcome.
Keywords:- Non-traumatic coma in children, infective etiology, Predictors of mortality.
Research article:-* Jahir Alam Khan1 and R. Umesh Shukla 2.
1 R&D division, MRD LifeSciences (P) Ltd., Lucknow, Uttar Pradesh, India.
2 Sai Nath Group of Education, Agra, Uttar Pradesh, India.
Abstract:- Five Bacterial isolates MJU1101, MJU1102, MJU1103, MJU1104 and MJU1105 were isolated from oil contaminated soil and were screened for oil degradation potential in MSM (minimal salt media) supplemented with 5% used engine oil by studying the growth and protein profile. Out of the five three isolates MJU1101, MJU1102 and MJU1105 showed good oil degradation potential, and were identified based on Bergey’s manual. All the three isolates individually and in combination were used to remediate the oil contaminated soil, and the effect of remediation on soil fertility was checked by sowing seeds of chickpea (Cicer arietinum) in treated and non treated soil. It was seen that no germination occurred in untreated soil but chickpea germinated and grew well in soil treated with isolate MJU1101 and MJU1102. Germination was good and faster in MJU1101.
Keywords:- Bioremediation, Oil spills, Oil degradation potential, Cicer arietinum, soil fertility.
Research article:- *R P Mishra1, Deepak2, Surya Pratap Singh2 & Raheel Anwar2.
1R & D Division, MRD LifeSciences, Lucknow, Uttar Pradesh, India.
2Stani Memorial P. G. College, Jaipur, Rajasthan, India.
Abstract:- Infections caused by drug resistant microorganisms result in significant increase in mortality, morbidity and cost related to prolonged treatments. To check the virulence and sensitivity towards drugs, a brief knowledge of culture conditions and nutritional requirements are needed. This study includes the culture optimization and nutritional evaluation of the Acinetobacter baumannii under different pH, media components and also the effect of different drugs. Intra & extracellular extracts obtained from the culture proved very good response against other virulent pathogens, thus a controlled culturing under strict observations can lead to an innovative antimicrobial components to be used as health care drug in future.
Keywords:- Acinetobacter baumannii, antimicrobial activity, MIC, E. coli, S. aureus, C. albicans MRSRA 1102 MH.