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Case Report:- * Dr. Niranjan M R1, Dr. Shetty shivakumar.M2, Dr. Jayasheelan. M. R3.
1MD, (General Medicine), DNB, MNAMS ,Assistant Professor, Dept. Of Medicine, Hassan Institute of Medical Sciences, Hassan 573201, Karnataka, India.
2MD, (General Medicine), Professor of Medicine, Mysore Medical College and Research Institute, Mysore, Karnataka, India.
3MD, (General Medicine), DNB, Senior resident, Dept. Of Medicine, Mysore Medical College and Research Institute, Mysore, Karnataka, India.
Abstract :- Takayasu arteritis is a rare chronic large vessel vasculitis primarily affecting the aorta and its main branches. Pulmonary arteries involvement is well described in Takayasu's arteritis. We report the case of a 40-year old male patient with Takayasu arteritis who presented with features of right heart failure and found to have severe left pulmonary trunk stenosis resulting in pulmonary hypertension and also with focal abdominal aortitis causing narrowing of left common iliac artery and resulted in left lower limb ischemia and gangrene, which made him to undergo above knee amputation. In our case the aortic arch and main branches were spared. Though the involvement of pulmonary artery is known, the presentation of features of right heart failure was the rarity in our case.
Keywords:- Takayasu arteritis, aorta, pulmonary artery, right heart failure.
Research article:- * Sayak Ganguli, Rahul Banik, Aditi Gangopadhyay and Abhijit Datta .
DBT CENTRE FOR BIOINFORMATICS, PRESIDENCY UNIVERSITY, 86/1 College Street, Kolkata 700073 India.
Abstract :- Machado-Joseph Disease and Alzheimer’s disease both are neurodegenerative disorders. MJD or SCA3 is a movement disorder and AD patients suffer from mental illness, depression, and dementia. MJD belongs to a class of genetic disorder called triplet repeat diseases. The mutant gene possesses increased number of CAG trinucleotide repeat which produces a mutated protein called ATAXIN3 and AD and this is due to hypophosphorylated microtubule associated protein Tau. The two proteins were modeled using modeller and then checked for protein quality. Then herbal lead compounds and their analogs were identified and screened with the target protein and energy values were compared. Results indicate that more than one herbal lead compounds could serve as potent inhibitors of mutated Tau and ATAXIN.
Keywords:- ATAXIN3, Tau, Modeller, Docking, ChemSketch, Herbal Ligands, Analogs
Original research article:-
*EBRU Karaca Umay¹, Alev Cevıkol¹, Ugur Tamkan¹, Serkan Umay², Aytul Cakcı¹
¹Ministry of Health Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Ankara, TURKEY.
² Ministry of Health Department of Administrative and Financial Affairs, Information Technology Coordinator, Ankara, TURKEY.
Abstract:- Introduction: In this study, it was aimed to assess any limitations among housewives with rheumatoid arthritis regarding their ability to conduct their responsibilities as housewives when compared to their healthy counterparts. We also aimed to determine the parameters that ideally evaluate the disability among housewives with Rheumatoid Arthritis as relates to their ability to properly fulfill their roles. Materials and Methods: 258 housewives with Rheumatoid arthritis and 210 healthy volunteer housewives were included in the study. All subjects were queried regarding the period of time that they spent for housework, child care and individual and social activities in one week. The spent time on each activity were compared between the patient and control groups. Results: Disability in all activities with the exception of indoor child care was determined in patients compared with healthy volunteers. The parameters determined to be most correlated were found among the applied scales: The Shortened Disabilities of the Arm, Shoulder and Hand Measure work module for determining disability in the conduct of housework activities and The Shortened Disabilities of the Arm, Shoulder and Hand Measure for disability in child care; grip strength for disability in personal activities; and Modified-Health Assessment Questionnaire for disability in social activities. Conclusion: Housewives with Rheumatoid Arthritis were determined to have disability with respect to their social life. The measurement methods such as grip strength, The Shortened Disabilities of the Arm, Shoulder and Hand Measure and work module of this and Modified-Health Assessment Questionnaire can be effective in the evaluation of disability.
Key words:- Rheumatoid arthritis, housewives, activities of daily living, quality of life, outcome assessment.