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Research article:- *R P Mishra1, Deepak2, Surya Pratap Singh2 & Raheel Anwar2.
1R & D Division, MRD LifeSciences, Lucknow, Uttar Pradesh, India.
2Stani Memorial P. G. College, Jaipur, Rajasthan, India.
Abstract:- Infections caused by drug resistant microorganisms result in significant increase in mortality, morbidity and cost related to prolonged treatments. To check the virulence and sensitivity towards drugs, a brief knowledge of culture conditions and nutritional requirements are needed. This study includes the culture optimization and nutritional evaluation of the Acinetobacter baumannii under different pH, media components and also the effect of different drugs. Intra & extracellular extracts obtained from the culture proved very good response against other virulent pathogens, thus a controlled culturing under strict observations can lead to an innovative antimicrobial components to be used as health care drug in future.
Keywords:- Acinetobacter baumannii, antimicrobial activity, MIC, E. coli, S. aureus, C. albicans MRSRA 1102 MH.
Research article:- *Nagdeote A.N.1, Dange N. S.2, Deshpande K. A.3 and Pawade Y. R. 4.
1Associate professor in Biochemistry, Department of Biochemistry, ESI Post Graduate Institute of Medical Sciences and Research, Andheri east, Mumbai , Maharashtra, India. 2Associate professor in Biochemistry, Government Medical College, Jagdalpur, Chhattisgarh, India.
3Assistant Professor in Biochemistry, Government Medical College, Nagpur, Maharashtra, India.
4Assistant Professor in Biochemistry and clinical nutrition Seth G S Medical College & KEM Hospital, Parel, Mumbai, Maharashtra, India.
Abstract:- Calcium and magnesium exert a major role upon diverse physiological process. Defect in calcium homeostasis have been seen in the asthma process. Antagonism of calcium and magnesium in the asthma and the beneficial effect of magnesium therapy in asthma have also been found in many studies. Children being the major target of asthma, we studied the blood levels of ionized calcium, total calcium, magnesium, sodium and potassium in 50 asthmatic children attending the pediatric OPD and compared with similar number of age and sex matched control. It was found that there was significant decrease in the levels of serum ionized calcium (1.15 ± 0.01 mmol/L), total calcium (8.93 ± 0.96mg/dl) and serum magnesium (1.91 ± 0.23 mg/dl)in asthmatic children as compare to the normal controls (1.24 ± 0.01 mmol/L), (9.35 ± 0.90 mg/dl) and (2.05 ± 0.23 mg/dl) respectively. The significant decrease was irrespective with the age, gender of patients and the severity of disease. In study group serum sodium (138 ± 3.4 mmol/L) and potassium (4.13 ± 0.46 mmol/L) showed no significant difference as compared to normal control group (139 ± 3.4 mmol/L) and (4.2 ± 0.53 mmol/L) respectively. A defect in calcium homeostasis may lead to increased utilization and translocation i.e. higher influx of calcium ions in bronchial smooth muscle cells and variety of other cells for e.g. mast cells which might have caused its lowering in plasma, ionized calcium being a physically active fraction which account for nearly half of the total calcium levels. These results suggest that airway hyper-responsiveness may be associated with altered calcium mobilization in airway smooth muscles. Utilization of magnesium for antagonism of calcium in the asthma process might have caused significant lowering in serum magnesium levels in asthmatic children as compare to normal controls.
Key words:- asthma, hyper-reactivity, ionized calcium, magnesium.
Review article:- *Amartya De, Prof. (Dr.) N.N Bala, Abhijit Bhattacharjee.
Department of Pharmacology, B.C.D.A College OF Pharmacy & Technology, 78 Jessore road (s), Hridaypur, Barasat, Kolkata-700127, West Bengal, India.
Abstract:- Glioblastoma multiforme is an aggressive disabling and deadly disease of the central nervous system. Early detection and treatment improve the prognosis for adults with glioblastoma. Advance practice nurses can help identify patients with glioblastoma multiforme early in the disease process and provide these patients with comprehensive nursing care.In this article we discuss the clinical presentation, diagnosis, postoperative care, treatment, symptom management, health promotion and physicochemical care for patients with glioblastoma multiforme.
Keywords:- Brain tumor, Glioblastoma Multiforme, Glial Cells, Pharmacological Treatment.