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Research article:-* Jahir Alam Khan1 and R. Umesh Shukla 2.
1 R&D division, MRD LifeSciences (P) Ltd., Lucknow, Uttar Pradesh, India.
2 Sai Nath Group of Education, Agra, Uttar Pradesh, India.
Abstract:- Five Bacterial isolates MJU1101, MJU1102, MJU1103, MJU1104 and MJU1105 were isolated from oil contaminated soil and were screened for oil degradation potential in MSM (minimal salt media) supplemented with 5% used engine oil by studying the growth and protein profile. Out of the five three isolates MJU1101, MJU1102 and MJU1105 showed good oil degradation potential, and were identified based on Bergey’s manual. All the three isolates individually and in combination were used to remediate the oil contaminated soil, and the effect of remediation on soil fertility was checked by sowing seeds of chickpea (Cicer arietinum) in treated and non treated soil. It was seen that no germination occurred in untreated soil but chickpea germinated and grew well in soil treated with isolate MJU1101 and MJU1102. Germination was good and faster in MJU1101.
Keywords:- Bioremediation, Oil spills, Oil degradation potential, Cicer arietinum, soil fertility.
Research article:- * Sayak Ganguli, Rahul Banik, Aditi Gangopadhyay and Abhijit Datta .
DBT CENTRE FOR BIOINFORMATICS, PRESIDENCY UNIVERSITY, 86/1 College Street, Kolkata 700073 India.
Abstract :- Machado-Joseph Disease and Alzheimer’s disease both are neurodegenerative disorders. MJD or SCA3 is a movement disorder and AD patients suffer from mental illness, depression, and dementia. MJD belongs to a class of genetic disorder called triplet repeat diseases. The mutant gene possesses increased number of CAG trinucleotide repeat which produces a mutated protein called ATAXIN3 and AD and this is due to hypophosphorylated microtubule associated protein Tau. The two proteins were modeled using modeller and then checked for protein quality. Then herbal lead compounds and their analogs were identified and screened with the target protein and energy values were compared. Results indicate that more than one herbal lead compounds could serve as potent inhibitors of mutated Tau and ATAXIN.
Keywords:- ATAXIN3, Tau, Modeller, Docking, ChemSketch, Herbal Ligands, Analogs
Original research article:-
*EBRU Karaca Umay¹, Alev Cevıkol¹, Ugur Tamkan¹, Serkan Umay², Aytul Cakcı¹
¹Ministry of Health Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Ankara, TURKEY.
² Ministry of Health Department of Administrative and Financial Affairs, Information Technology Coordinator, Ankara, TURKEY.
Abstract:- Introduction: In this study, it was aimed to assess any limitations among housewives with rheumatoid arthritis regarding their ability to conduct their responsibilities as housewives when compared to their healthy counterparts. We also aimed to determine the parameters that ideally evaluate the disability among housewives with Rheumatoid Arthritis as relates to their ability to properly fulfill their roles. Materials and Methods: 258 housewives with Rheumatoid arthritis and 210 healthy volunteer housewives were included in the study. All subjects were queried regarding the period of time that they spent for housework, child care and individual and social activities in one week. The spent time on each activity were compared between the patient and control groups. Results: Disability in all activities with the exception of indoor child care was determined in patients compared with healthy volunteers. The parameters determined to be most correlated were found among the applied scales: The Shortened Disabilities of the Arm, Shoulder and Hand Measure work module for determining disability in the conduct of housework activities and The Shortened Disabilities of the Arm, Shoulder and Hand Measure for disability in child care; grip strength for disability in personal activities; and Modified-Health Assessment Questionnaire for disability in social activities. Conclusion: Housewives with Rheumatoid Arthritis were determined to have disability with respect to their social life. The measurement methods such as grip strength, The Shortened Disabilities of the Arm, Shoulder and Hand Measure and work module of this and Modified-Health Assessment Questionnaire can be effective in the evaluation of disability.
Key words:- Rheumatoid arthritis, housewives, activities of daily living, quality of life, outcome assessment.
Research article:-*Swapna Velivela 1, Sashmitha Samuel.B1, V. Asha Ranjani1, P.Muthuprasanna2.
1MLR Institute of Pharmacy, Dundigal (V), Quthbullapur (M), Hyderabad-43, Andhra Pradesh, India.
2.Hindu college of Pharmacy, Guntur-522002, A.P , India.
Abstract:-Trimetazidine (TMZ) is an effective and well tolerated anti-anginal drug that possesses protective properties against ischemia- induced heart injury. However it has a short coming of a shorter half-life. Hence, in the present investigation extended release pellets of Trimetazidine hydrochloride (TMZ) were prepared using ethyl cellulose polymers to achieve a prolonged therapeutic action by continuously releasing medication over an extended period of time after administration of a single dose. The sustained release formulations were optimized by employing suspension / solution layering technique. The drug release characteristics of all the formulations were evaluated by HPLC technique and stability studies were carried out for about three months at different temperature and humidity conditions.
Key words:- Ethyl cellulose (EC), Sustained release (SR), Trimetazidine (TMZ)
Research article:- *Nagoba Shivappa N.1 , Purushotham Rao K.2, Zakaullah S.3 .
1Karpagam University, Coimbatore (T.N.) India.
2H.K.E.’s College of Pharmacy, Gulbarga (Karnataka) India.
3Al-Badar Rural Dental College & Hospital, Gulbarga (Karnataka) India.
Abstract:- The present investigation aims to design, prepare and evaluate the medicated candy based tablet lozenges of Clotrimazole for paediatric, geriatric and Dysphagic patients and to investigate the suitability of Isomalt and/or liquid glucose as the sugar substitute in the prepared lozenges. The candy based lozenges were prepared by heating and congealing method in a candy based industry on request with sugar base, Acacia, citric acid artificial flavours and colours and other essential excipients. The prepared medicated lozenges were characterized for drug content uniformity, hardness, thickness, weight variation, friability, moisture content, in vitro disintegration and dissolution by pharmaceutical standard methods. Accelerated stability study conducted as per ICH guidelines (zone IV) at 45°C and 75% relative humidity over a period of seven weeks found that there wasn’t any substantial interaction between the drugs, flavor and color and the prepared formulations were stable.
Keywords:- Clotrimazole, lozenges, oral thrush.