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Research article:-
*Goswami Dhruba Sankar1, Goyal Sandeep 1, Goyal Deepak1, Sharma Rini1, Mehta Naveen2, Puja Kumari3, Kunwar S Pramod 4
1S.D. College of Pharmacy, Barnala- 148 101, Punjab, India.
2 B.R. nahata college of pharmacy ,Mandsaur (M.P)-458001,India.
3Himalayan Pharmacy Institute, Majhitar, E.Sikkim-737136, India.
4Mandsaur Institute of Pharmacy, Mandsaur (M.P)-458001, India.
Abstract:- Famotidine is a histamine H2-receptor antagonist. It is widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux disease, and erosive esophagitis. The effective treatment of erosive esophagitis requires administration of 20 mg of Famotidine 4 times a day. a conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations; thus a sustained release dosage form of famotidine is desirable. The short biological half-life of drug (2.5-4 hours) also favors development of a sustained release formulation. The present study aims to reduce the dosing frequency by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine synthetic (HPMC-K4M, SCMC and sodium alginate) and natural (tragacanth and acacia) hydrophilic polymers have been made to prepare total eight formulations. Further, these formulations were subjected to different evaluation studies like friability, content uniformity, surface pH, wash-off and dissolution tests. All the tests were performed using standard methods. Results for in vitro drug release and wash-off studies suggest that the formulation (FHT) containing HPMC-K4M and tragacanth has shown better mucoadhesive property. Other studies have shown satisfactory results in all eight formulations. Thus, the present investigation suggests the combination of HPMC-K4M and tragacanth, as hydrophilic polymers for preparation of famotidine mucoadhesive tablets.
Key words:- Famotidine , Mucoadhesive tablets
Research article:-* A Poorsattar Bejeh Mir.
Undergraduate Student, Dentistry Student Research Committee (DSRC), Dentistry School, Babol University of Medical Sciences, Babol, Iran.
Abstract: Since discovery of endothelial-derived relaxing factor EDRF) at 1980, which was named nitric oxide (NO) later, many attempts were done to elucidate the fact and reality of this multi potential molecule. Indeed many controversies are raised when its contrasting role in health and disease status was observed. Up to the current knowledge, this double-edged sword is involved in many pathophysiologic processes with an immunoprotective role to a very potent destructive property. Periodontitis may be reviewed as a localized vasculopathy with possible involvement of the arginine-NO pathway, vascular endothelial growth factor (VEGF) over production and release of reactive oxygen species (ROS) with ultimate tissue damage and bone loss. There is a considerable body of evidence in the medical literature that manipulation of nitric oxide pathway, inhibition of VEGF and reinforcement of antioxidant systems has improved the affected tissue when NO, VEGF or ROS are suspected as causative factors. In this context, possible therapeutic targets to treat periodontitis are discussed with a glance at the current medications for the systemic diseases with somewhat similar underlying pathophysiology to periodontitis.
Keywords: Antioxidant, angiogenesis, arginine, free radical, nitric oxide, periodontitis.
Research article:- *Amit Pandey1, Arti Kaushik2, Sudeep Kumar Tiwari2
1R&D Division, MRD LifeSciences, Lucknow-226010, India.
2 IIMT, Aligarh- 202001, India.
Abstract:- The present study was carried out to find out the antimicrobial activity of ethanolic, methanolic, ethyl acetate & hot water extract of lemon fruit parts like peels & seeds. Antimicrobial analysis was done by using agar well diffusion method against bacterial and fungal pathogens. Methanolic extract of lemon peels exhibited the maximum zone of inhibition against Pseudomonas aeruginosa whereas hot water extract of lemon peels exhibited least zone of inhibition. Ethanolic extract of lemon seeds showed maximum zone of inhibition against Pseudomonas aeruginosa whereas hot water extract showed least zone of inhibition. MIC value was determined by using micro broth dilution method. The least concentration was obtained 2.4 mg/ml for ethanolic and hot water extracts of lemon peels against S. aureus. The MBC value also determined and phytochemical analysis showed the presence of tannins, glycosides, reducing sugars and flavonoids.
Keywords:- Antimicrobial analysis, methanolic, ethanolic & hot water plant extract, MIC, MBC, zone of inhibition, phytochemical analysis.
Research article:-Vaiyapuri Anandh1, Ivor Peter D’Sa2 , Jagatheesan Alagesan3, Vandana J. Rathod4.
1 Vaiyapuri Anandh - Professor & Principal, Saveetha College of Physiotherapy, Saveetha University, Chennai, India.
2 Ivor Peter D’Sa - Professor & Head, Department of Medicine, KSHEMA, Nitte University, Mangalore, India.
3 Jagatheesan Alagesan - Associate Professor, KJ Pandya College of Physiotherapy, Sumandeep Vidyapeeth, Vadodara, India.
4Vandana J. Rathod - Lecturer, KJ Pandya College of Physiotherapy, Sumandeep Vidyapeeth, Vadodara, India.
Abstract: Background and Objective: HIV infection is one of the chronic illnesses with an uncertain natural disease history. Exercise is well accepted as an adjunct therapy in the management of HIV. This study is intended to ascertain the effects of Progressive Resistance exercise on cardiovascular fitness and quality of life. Study Design: Pilot study Setting: Sneha Sadan HIV Home, Kaikamba. Outcome Measures: 3 Minute Step Test and MOS - HIV Health Survey Method: Fifteen HIV infected individuals were given Progressive Resistance exercise for 45 minutes, three days per week for three months after obtaining informed consent. Cardiovascular fitness and quality of life were assessed at the beginning and after three months of exercises. Result: The Mean ± SD before and after intervention for 3 minute step test is 3.60 ± 0.63 and 4.33 ± 0.72, for MOS-HIV Health Survey is 54.53 ± 8.44 and 62.40 ± 7.28 with p value equal to 0.001 for both outcome measures. Conclusion: This study concludes that Progressive Resistance exercises are effective for improving cardiovascular fitness and quality of life in HIV infected individuals.
Key Words: HIV, Progressive Resistance Exercises, Cardiovascular Fitness, Quality Of Life
Research article:- S.Prathap1, Arun Maiya2 , Saraswathi3, Jayachandran Dare4
1 Assistant Professor, College of Physiotherapy, Saveetha University, Chennai, India.
2 Associate Dean & head, Department of Physiotherapy, Manipal University, Manipal, India. 3Head of department, Dept of Anatomy, Saveetha Medical College, Chennai, India.
4 Director, Biomedical Research Unit & Laboratory Animal Centre, Saveetha University, Chennai, India.
Abstract:- Peripheral neuropathies have been described in patients with primary and secondary diabetes of diverse causes suggesting a common etiologic mechanism based on chronic hyperglycemia. The extensive review of literature reveals that there is paucity of studies on scope of management for this particular complication, this urges to do a study on this problem with low level laser irradiation which is recognized worldwide for its tissue healing properties. The Effect of various dosages of low level Laser Therapy in Experimental Diabetic Neuropathy was evaluated with 42 Healthy adult male albino wistar rats. The animals were induced with Alloxan intraperitonealy and blood glucose status was examined with Glucometer. Diabetic neuropathy status was measured with EMG-NCV for MNCV. The rats were than divided into 7 groups and irradiated with laser dosages ranging from 3j/cm2 to 8j/cm2 and one group was kept as control. On analyzing pre and post MNCV values, dosages of 3-4j/ cm2 showed extremely significant p values 5-6j/cm2 showed satisfactorily significant results and 7-8j/cm2 and control groups did not show any significant effect. This MNCV results are important finding of the study that the calculation of correct dosage of laser is very important, like higher dosage can have photo bio-inhibitory effect.
Key Words:- Low Level Laser Irradiation, Diabetic Neuropathy, Motor Nerve Conduction Velocity