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Research article:-* Dr. Yadavalli Guruprasad MDS1, Dr. Dinesh Singh Chauhan MDS, DNB 2
1 Assistant Professor ,Department of Oral & Maxillofacial Surgery AME’S Dental College Hospital & Research Centre, Raichur-584103, Karnataka, India.
2 Reader ,Department of Oral & Maxillofacial Surgery AME’S Dental College Hospital & Research Centre, Raichur-584103, Karnataka, India.
Abstract:- Solitary bone cyst (SBC) is an uncommon disorder of the jaw bones, as well as other skeletal bones, particularly the long bones. It usually occurs in the metaphyseal region of long bones comprising only around 2% of all bone cysts affecting this area. Solitary bone cyst is an asymptomatic, slow growing lesion commonly diagnosed incidentally during routine radiographic examination of the jaw bones. Its etiology is not clear and trauma has not been definitely determined to be the cause. It occurs mainly in children and young adults, and the body of the mandible is the most common site. We report a case of solitary bone cyst of the mandible in a 7 year old female child.
Keywords:- Solitary bone cyst, trauma, mandible.
Research article:- * C.Venkatramaniah¹, A.Mary Antony Praba².
¹ Assistant Professor, Department of Anatomy, Sri Lakshmi Narayana Institute of Basic Medical Sciences, Pondy, India.
² Assistant Professor, Department of Anatomy, Tagore Medical College, Chennai, India
Abstract:- The skull is the ossified, bony structure that encloses and protects the brain, internal extensions of sensory organs, and some facial structures. When a complete skeleton is available, the level of reliability in establishing sex, age, and race through anthropometrics is almost 100%. Pelvic bones alone offer a 95% reliability , while pelvic bones plus the skull - 98%. By adulthood all the features in the skull are prominent and so identification of sex of a person is easy with in 30 years age. The smoother the skull, the older the person. So it is bit difficult to identify the sex above 30. So it is difficult to identify the sex of the person by using these three prominences alone. But there are certain points on the median plane of the skull which are helpful in finding the sex of a person. Though a number of median points are available with skull, we have selected only 9 prominent points were taken for the study they are the- Vertex, Glabella, Nasion, Akanthion, Bregma, Lambda, Inion, Basion And Opisthion(3,14). All the points are measured from the vertex. The result shows a considerable variation between the mean values of male and female skulls. The female skull shows a relatively low value in average than the male skulls. So this can be utilized in differenciating the sex of a person.
Keywords:- Vertex, glabella, nasion, akanthion, bregma, lambda, inion, basion, opisthion.
Research article:-
*Shirode Abhay R, Khanvilkar Vineeta V, Shah Jignesh M, Chitnis Aditi P, Kotadia Bhargav V, Kadam Vilasrao J.
Department of Pharmaceutical Chemistry and Pharmaceutical Analysis,Bharati Vidyapeeth’s College of Pharmacy, Navi Mumbai, Sector -8, CBD, Belapur, Navi Mumbai-400 614.
Abstract: Bioanalysis plays a key role in drug discovery process. When medicinal chemists are in the lead optimization phase of new drug discovery it is needed to know if their latest NCEs pass various drug metabolism and pharmacokinetics (DMPK) screens that check for their suitability in terms of pharmacokinetics and drug metabolism (e.g., in vitro stability, p450 inhibition and absorption potential). Bioanalytical processes can significantly enhance the drug discovery and development process. Bioanalysis helps a formulation scientists and clinical research team for the study of Bioavailability (BA) and bioequivalence (BE) of a developed dosage form of a particular drug. The use of high performance liquid chromatography (HPLC) has been the state-of-the-art analytical tool for drug-discovery bioanalysis and BA-BE studies for many decades. Over the time, the HPLC systems have improved and coupled with mass spectrometry (MS) and evolved as LC-MS then it is modified as LC-MS/MS. HPTLC is also used for the analysis of biological samples. In recent years when UPLC became commercially available, this brought biggest change. While MS/MS systems have also improved over last two decades, the basic principle of using selected reaction monitoring (SRM) for the analytical detection of the analyte of interest has remained the same. Thus we have been well served by the HPLC–MS/MS paradigm as our pre-eminent tool of choice for assaying both in vitro and in vivo samples of various types. Bioanlytical method development is a very crucial step to quantitate drug from biological matrix. Method must be established and validated to demonstrate total recovery, accuracy, precision, and robustness to determine the amount of drug present in the given biological matrix. This review will explore the approaches, chromatographic methods, and extraction techniques which are used and reported by different researchers for estimation of drug from various biological samples. This will also give valuable inputs to design a protocol for validation of a developed bioanalytical method. We predict that this review will provide significant ‘value-added’ data to many analysts and will certainly shorten the timelines of referencing for method development task.
Keywords: High performance liquid chromatography, Bioanalysis, reference.
Research article:- *Amit Pandey1, Afsheen2, Firdous Ara2, Sudeep Kumar Tiwari2
1R&D Division, MRD LifeSciences, Lucknow-226010, India.
2 IIMT, Aligarh- 202001, India.
Abstract:- The antibiotic sensitivity tests were performed for the isolated cultures obtained from hospital waste and laundry water in Lucknow. During the study, out of 16 cultures, 3 bacterial isolates were identified with the help of Bergey’s manual. They included; Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus species. The 6 antibiotics were used Amoxicillin, Ampicillin, Tetracycline, Ofloxacin, Chloramphenicol, Ciprofloxacin at lower to higher conc. (10µg- 10mg). The best results obtained for Ofloxacin, Ampicillin, Chloramphenicol antibiotics (10µg-1mg). The resistance of the 3 bacterial isolates to the commonly used antibiotics revealed that for all antibiotics, all the cultures were showing resistance and against Ofloxacin, it was 100% and for Chloramphenicol, the resistance activity was measured 80%. The MIC and MBC were also performed for identified cultures.
Key words:- Antibiotic sensitivity test, Resistance, MIC and MBC.
Research article:- *Dr. Sriram Raghavendran, M.B.B.S 1 and Dr. S.Swaminathan, , Ph.D., FACBI.,2
1 J-9, Sreyas “Yadugiri” Apts.,30/A, C.P. Ramasamy Road, Alwarpet, Chennai – 600018, Tamil Nadu, India.
2 Senior Consultant and Head, Biochemistry Department, Apollo Specialty Hospital, 3rd Floor, Laboratory wing, No.320, Padma Complex, Anna Salai, Chennai – 600035, Tamil Nadu, India. Abstract:- The main research focus of this project involved investigating the presence of Hypomagnesemia, if any, among non-hospitalised patients with fasting Hyperglycemia and the relationship between Serum Mg levels and Fasting Glucose levels in males as well as females. The research methodology used in the study involved the analysis of serum Magnesium levels in non-hospitalised outpatients with suspected Pre-diabetes/Impaired fasting glucose or Type 2 Diabetes by analysing their blood samples using the Olympus AU480® Chemistry Analyzer. The t-test was used for the statistical analysis of the data obtained using statistical software from the internet. The population size used in the study has been taken as n=60 and includes all people who have returned to the outpatient clinic for a repeat blood glucose analysis. The result and conclusion of this study is that there is a significant inverse relation between the levels of Magnesium and Glucose in a person’s body: In all (n=60) subjects, r = -0.890, P <0.0001 and t = -14.87 overall. In the male (n=30) population, r = -0.861. The P <0.0001 , with a t value of -8.96. In the female (n=30) population, r = -0.919, P <0.0001, and t = -12.33. The overall Incidence of Hypomagnesemia in patients with Hyperglycemia in this population of n=60 was found to be 31.67%. It is imperative to monitor suspected Pre-Diabetic/Diabetic patients for Serum Magnesium.
Key words: Fasting Plasma Glucose, Glucose tolerance, Hyperglycemia, Hypomagnesemia, Impaired Fasting Glucose, Impaired Glucose tolerance, Magnesium, Type 2 DM.