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Research article:-* A Poorsattar Bejeh Mir.
Undergraduate Student, Dentistry Student Research Committee (DSRC), Dentistry School, Babol University of Medical Sciences, Babol, Iran.
Abstract: Since discovery of endothelial-derived relaxing factor EDRF) at 1980, which was named nitric oxide (NO) later, many attempts were done to elucidate the fact and reality of this multi potential molecule. Indeed many controversies are raised when its contrasting role in health and disease status was observed. Up to the current knowledge, this double-edged sword is involved in many pathophysiologic processes with an immunoprotective role to a very potent destructive property. Periodontitis may be reviewed as a localized vasculopathy with possible involvement of the arginine-NO pathway, vascular endothelial growth factor (VEGF) over production and release of reactive oxygen species (ROS) with ultimate tissue damage and bone loss. There is a considerable body of evidence in the medical literature that manipulation of nitric oxide pathway, inhibition of VEGF and reinforcement of antioxidant systems has improved the affected tissue when NO, VEGF or ROS are suspected as causative factors. In this context, possible therapeutic targets to treat periodontitis are discussed with a glance at the current medications for the systemic diseases with somewhat similar underlying pathophysiology to periodontitis.
Keywords: Antioxidant, angiogenesis, arginine, free radical, nitric oxide, periodontitis.
Research article:-
Ashok P. Salave and *P. Gopal Reddy.
Shri Dnyaneshwar Mahavidyalaya, Newasa, Dist-Ahmednagar,India. *P.G. Department of Botany, P.V.P. College, Pravaranagar,Ahmednagar, India.
Abstract:-An extensive field visits were arranged in Dongargan areas to document the traditional ethnobotanical information hidden among the local inhabitants has been gathered through verbal and informal interviews at their working places during 2007-2008 is presented here in their language. In this paper 24 species belonging to 24 genera from 17 families used by the local inhabitants at local level in their routine life has been reported here to fill up the gap of ethnobotanical knowledge in this area.
Keywords:- Ethnobotany, ethnoflora, Dongargan, Traditional uses.
Research article:- * Sayantan Ray 1, K.Nagaiah. 2
1* NSHM College of Pharmaceutical Technology, Kolkata, West Bengal, India.
2Organic and Bimolecular Chemistry Division, Indian Institute of Chemical Technology (CSIR), Hyderabad, India.
Abstract: The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole plant allowed the isolation of a pregnane glycoside known as Carumbelloside-II. Carumbelloside-II was evaluated for both antinociceptive and anti-inflammatory activity. The antinociceptive activity was evaluated in acidic acid-induced abdominal constriction test method in Swiss albino mice, while anti-inflammatory activity was evaluated in carrageenan-induced paw edema in Wistar rats. Carumbelloside-II has significant antinociceptive and anti-inflammatory activity. These results of present study confirm the use of Cralluma umbellata traditionally for the treatment of painful and inflammatory condition.
Keywords: Caralluma Umbellata; Asclepiadaceae; Pregnane glycoside; Anti-inflammatory activity, Carumbelloside – II.
Research article:- *Dr. Sriram Raghavendran, M.B.B.S 1 and Dr. S.Swaminathan, , Ph.D., FACBI.,2
1 J-9, Sreyas “Yadugiri” Apts.,30/A, C.P. Ramasamy Road, Alwarpet, Chennai – 600018, Tamil Nadu, India.
2 Senior Consultant and Head, Biochemistry Department, Apollo Specialty Hospital, 3rd Floor, Laboratory wing, No.320, Padma Complex, Anna Salai, Chennai – 600035, Tamil Nadu, India. Abstract:- The main research focus of this project involved investigating the presence of Hypomagnesemia, if any, among non-hospitalised patients with fasting Hyperglycemia and the relationship between Serum Mg levels and Fasting Glucose levels in males as well as females. The research methodology used in the study involved the analysis of serum Magnesium levels in non-hospitalised outpatients with suspected Pre-diabetes/Impaired fasting glucose or Type 2 Diabetes by analysing their blood samples using the Olympus AU480® Chemistry Analyzer. The t-test was used for the statistical analysis of the data obtained using statistical software from the internet. The population size used in the study has been taken as n=60 and includes all people who have returned to the outpatient clinic for a repeat blood glucose analysis. The result and conclusion of this study is that there is a significant inverse relation between the levels of Magnesium and Glucose in a person’s body: In all (n=60) subjects, r = -0.890, P <0.0001 and t = -14.87 overall. In the male (n=30) population, r = -0.861. The P <0.0001 , with a t value of -8.96. In the female (n=30) population, r = -0.919, P <0.0001, and t = -12.33. The overall Incidence of Hypomagnesemia in patients with Hyperglycemia in this population of n=60 was found to be 31.67%. It is imperative to monitor suspected Pre-Diabetic/Diabetic patients for Serum Magnesium.
Key words: Fasting Plasma Glucose, Glucose tolerance, Hyperglycemia, Hypomagnesemia, Impaired Fasting Glucose, Impaired Glucose tolerance, Magnesium, Type 2 DM.
Research article:-Vaiyapuri Anandh1, Ivor Peter D’Sa2 , Jagatheesan Alagesan3, Vandana J. Rathod4.
1 Vaiyapuri Anandh - Professor & Principal, Saveetha College of Physiotherapy, Saveetha University, Chennai, India.
2 Ivor Peter D’Sa - Professor & Head, Department of Medicine, KSHEMA, Nitte University, Mangalore, India.
3 Jagatheesan Alagesan - Associate Professor, KJ Pandya College of Physiotherapy, Sumandeep Vidyapeeth, Vadodara, India.
4Vandana J. Rathod - Lecturer, KJ Pandya College of Physiotherapy, Sumandeep Vidyapeeth, Vadodara, India.
Abstract: Background and Objective: HIV infection is one of the chronic illnesses with an uncertain natural disease history. Exercise is well accepted as an adjunct therapy in the management of HIV. This study is intended to ascertain the effects of Progressive Resistance exercise on cardiovascular fitness and quality of life. Study Design: Pilot study Setting: Sneha Sadan HIV Home, Kaikamba. Outcome Measures: 3 Minute Step Test and MOS - HIV Health Survey Method: Fifteen HIV infected individuals were given Progressive Resistance exercise for 45 minutes, three days per week for three months after obtaining informed consent. Cardiovascular fitness and quality of life were assessed at the beginning and after three months of exercises. Result: The Mean ± SD before and after intervention for 3 minute step test is 3.60 ± 0.63 and 4.33 ± 0.72, for MOS-HIV Health Survey is 54.53 ± 8.44 and 62.40 ± 7.28 with p value equal to 0.001 for both outcome measures. Conclusion: This study concludes that Progressive Resistance exercises are effective for improving cardiovascular fitness and quality of life in HIV infected individuals.
Key Words: HIV, Progressive Resistance Exercises, Cardiovascular Fitness, Quality Of Life