DocumentsDate added
Research article:-
*Eryılmaz Müjde1, Akın Ahmet2, Altanlar Nurten2
1Ph.D, 2Prof.Dr. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Abstract:-Antiseptics are an essential part of infection control practices and aid in the prevention of nosocomial infections. The selection of the proper antimicrobial agent is a very crucial step before application. The aim of this study was to compare the efficacy of 2% chlorhexidine gluconate (2% CHG) and 10% povidone iodine (10% PVP-I) alone and in combination with 70% 2-propanol (70% 2-P) against nosocomial methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis isolates. A total of 15 MRSA and 15 E. faecalis strains isolated from blood cultures of hospitalized patients as nosocomial infection agents in Ankara University, Faculty of Medicine, Ibn-i Sina Hospital, Ankara, Turkey were included in the study. Susceptibilities of the isolates to antiseptics were investigated by quantitative suspension test at 30 seconds contact time. All of the isolates were found susceptible to 2% CHG in 70% 2-P and 10% PVP-I in 70% 2-P. However, three MRSA and four E.faecalis isolates were found resistant to 2% CHG; three MRSA and three E.faecalis isolates were found resistant to 10% PVP-I . Our study has demonstrated that 2% CHG in 70% 2-P and 10% PVP-I in 70% 2-P provide a significantly better antimicrobial activity than 10% PVP-I and 2% CHG alone at 30 seconds contact time. According to the results, enhanced skin antisepsis may be achieved with 2% CHG in 70% 2-P or 10% PVP-I in 70% 2-P compared with the 2% CHG and 10% PVP-I alone.
Key Words:- Chlorhexidine gluconate, Povidone iodine, 2-propanol, Skin antisepsis.